First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique

Detalhes bibliográficos
Autor(a) principal: Caterino-de-Araujo,Adele
Data de Publicação: 2009
Outros Autores: Manuel,Rolanda Carmen Rafael, Bianco,Rosana Del, Santos-Fortuna,Elizabeth, Magri,Mariana Cavalheiro, Silva,Joyce Matie Kinoshita, Bastos,Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300008
Resumo: Human herpesvirus 8 (HHV-8), the etiological agent of Kaposi's sarcoma (KS), is endemic in parts of the sub-Saharan, and KS has increased concomitantly with the HIV/AIDS epidemic. In Mozambique (MZ), no data concerning HHV-8 infection was available, thus the main of this work was to investigate, for the first time, the presence of HHV-8 infection in Maputo, MZ. Latent and lytic HHV-8-specific antibodies were assessed in blood samples from 189 individuals from the Central Hospital of Maputo, MZ, using "in-house" immunofluorescence assays conducted in São Paulo, Brazil. The results obtained were analyzed according to socio-demographic and clinical variables using the Chi-square test and logistic regression. An HHV-8 seropositivity of 1.8% and 9.7% was detected among 57 medical students and 31 individuals from the staff, respectively, in contrast to 16.4% detected among 67 out-patients. Concerning 34 hospitalized patients from the Dermatology Unit, 47.1% were HHV-8-seropositive overall, while the rate was 85.7% among KS patients. The present survey, conducted in Maputo, MZ, demonstrates great variation in HHV-8 infection frequencies depending on the group analyzed and epidemiological variables. An association between HHV-8 seropositivity and male gender (OR 5.72), the central origin of patients (OR 5.33), blood transfusions (OR 3.25), and KS (OR 24.0) was detected among hospitalized patients, and primary school (OR 7.18) and HIV-1 infection (OR 8.76) among out-patients.
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spelling First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, MozambiqueHuman herpesvirus 8 (HHV-8)serologyMozambiquefrequencyKaposi's sarcomaHuman herpesvirus 8 (HHV-8), the etiological agent of Kaposi's sarcoma (KS), is endemic in parts of the sub-Saharan, and KS has increased concomitantly with the HIV/AIDS epidemic. In Mozambique (MZ), no data concerning HHV-8 infection was available, thus the main of this work was to investigate, for the first time, the presence of HHV-8 infection in Maputo, MZ. Latent and lytic HHV-8-specific antibodies were assessed in blood samples from 189 individuals from the Central Hospital of Maputo, MZ, using "in-house" immunofluorescence assays conducted in São Paulo, Brazil. The results obtained were analyzed according to socio-demographic and clinical variables using the Chi-square test and logistic regression. An HHV-8 seropositivity of 1.8% and 9.7% was detected among 57 medical students and 31 individuals from the staff, respectively, in contrast to 16.4% detected among 67 out-patients. Concerning 34 hospitalized patients from the Dermatology Unit, 47.1% were HHV-8-seropositive overall, while the rate was 85.7% among KS patients. The present survey, conducted in Maputo, MZ, demonstrates great variation in HHV-8 infection frequencies depending on the group analyzed and epidemiological variables. An association between HHV-8 seropositivity and male gender (OR 5.72), the central origin of patients (OR 5.33), blood transfusions (OR 3.25), and KS (OR 24.0) was detected among hospitalized patients, and primary school (OR 7.18) and HIV-1 infection (OR 8.76) among out-patients.Brazilian Society of Infectious Diseases2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300008Brazilian Journal of Infectious Diseases v.13 n.3 2009reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702009000300008info:eu-repo/semantics/openAccessCaterino-de-Araujo,AdeleManuel,Rolanda Carmen RafaelBianco,Rosana DelSantos-Fortuna,ElizabethMagri,Mariana CavalheiroSilva,Joyce Matie KinoshitaBastos,Ruieng2010-02-10T00:00:00Zoai:scielo:S1413-86702009000300008Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2010-02-10T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
title First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
spellingShingle First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
Caterino-de-Araujo,Adele
Human herpesvirus 8 (HHV-8)
serology
Mozambique
frequency
Kaposi's sarcoma
title_short First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
title_full First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
title_fullStr First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
title_full_unstemmed First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
title_sort First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
author Caterino-de-Araujo,Adele
author_facet Caterino-de-Araujo,Adele
Manuel,Rolanda Carmen Rafael
Bianco,Rosana Del
Santos-Fortuna,Elizabeth
Magri,Mariana Cavalheiro
Silva,Joyce Matie Kinoshita
Bastos,Rui
author_role author
author2 Manuel,Rolanda Carmen Rafael
Bianco,Rosana Del
Santos-Fortuna,Elizabeth
Magri,Mariana Cavalheiro
Silva,Joyce Matie Kinoshita
Bastos,Rui
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caterino-de-Araujo,Adele
Manuel,Rolanda Carmen Rafael
Bianco,Rosana Del
Santos-Fortuna,Elizabeth
Magri,Mariana Cavalheiro
Silva,Joyce Matie Kinoshita
Bastos,Rui
dc.subject.por.fl_str_mv Human herpesvirus 8 (HHV-8)
serology
Mozambique
frequency
Kaposi's sarcoma
topic Human herpesvirus 8 (HHV-8)
serology
Mozambique
frequency
Kaposi's sarcoma
description Human herpesvirus 8 (HHV-8), the etiological agent of Kaposi's sarcoma (KS), is endemic in parts of the sub-Saharan, and KS has increased concomitantly with the HIV/AIDS epidemic. In Mozambique (MZ), no data concerning HHV-8 infection was available, thus the main of this work was to investigate, for the first time, the presence of HHV-8 infection in Maputo, MZ. Latent and lytic HHV-8-specific antibodies were assessed in blood samples from 189 individuals from the Central Hospital of Maputo, MZ, using "in-house" immunofluorescence assays conducted in São Paulo, Brazil. The results obtained were analyzed according to socio-demographic and clinical variables using the Chi-square test and logistic regression. An HHV-8 seropositivity of 1.8% and 9.7% was detected among 57 medical students and 31 individuals from the staff, respectively, in contrast to 16.4% detected among 67 out-patients. Concerning 34 hospitalized patients from the Dermatology Unit, 47.1% were HHV-8-seropositive overall, while the rate was 85.7% among KS patients. The present survey, conducted in Maputo, MZ, demonstrates great variation in HHV-8 infection frequencies depending on the group analyzed and epidemiological variables. An association between HHV-8 seropositivity and male gender (OR 5.72), the central origin of patients (OR 5.33), blood transfusions (OR 3.25), and KS (OR 24.0) was detected among hospitalized patients, and primary school (OR 7.18) and HIV-1 infection (OR 8.76) among out-patients.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702009000300008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.13 n.3 2009
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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