Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature

• Autor(a) principal: Slavov,Svetoslav Nanev
• Data de Publicação: 2013
• Outros Autores: Kashima,Simone, Silva-Pinto,Ana Cristina, Amarilla,Alberto Anastacio, Aquino,Victor Hugo, Covas,Dimas Tadeu
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Brazilian Journal of Infectious Diseases
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100017
• topic: Human parvovirus B19; Viral load; Aplastic crisis; Subgenotypes

Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. Both cases had high viral load and identical subgenotype, indicating that the viral molecular characteristics play a minimal role in the infection outcome.