Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100026 |
Resumo: | Abstract Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p < 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p = 0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker. |
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Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial diseaseCarbohydrate antigen 19-9Nontuberculous mycobacteriaTuberculosisBiological markerAbstract Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p < 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p = 0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker.Brazilian Society of Infectious Diseases2016-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100026Brazilian Journal of Infectious Diseases v.20 n.1 2016reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2015.09.005info:eu-repo/semantics/openAccessHong,Ji YoungJang,Sun HeeKim,Song YeeChung,Kyung SooSong,Joo HanPark,Moo SukKim,Young SamKim,Se KyuChang,JoonKang,Young Aeeng2016-03-14T00:00:00Zoai:scielo:S1413-86702016000100026Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2016-03-14T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
spellingShingle |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease Hong,Ji Young Carbohydrate antigen 19-9 Nontuberculous mycobacteria Tuberculosis Biological marker |
title_short |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_full |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_fullStr |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_full_unstemmed |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
title_sort |
Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease |
author |
Hong,Ji Young |
author_facet |
Hong,Ji Young Jang,Sun Hee Kim,Song Yee Chung,Kyung Soo Song,Joo Han Park,Moo Suk Kim,Young Sam Kim,Se Kyu Chang,Joon Kang,Young Ae |
author_role |
author |
author2 |
Jang,Sun Hee Kim,Song Yee Chung,Kyung Soo Song,Joo Han Park,Moo Suk Kim,Young Sam Kim,Se Kyu Chang,Joon Kang,Young Ae |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hong,Ji Young Jang,Sun Hee Kim,Song Yee Chung,Kyung Soo Song,Joo Han Park,Moo Suk Kim,Young Sam Kim,Se Kyu Chang,Joon Kang,Young Ae |
dc.subject.por.fl_str_mv |
Carbohydrate antigen 19-9 Nontuberculous mycobacteria Tuberculosis Biological marker |
topic |
Carbohydrate antigen 19-9 Nontuberculous mycobacteria Tuberculosis Biological marker |
description |
Abstract Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p < 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p = 0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100026 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100026 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2015.09.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.20 n.1 2016 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209243680997376 |