Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C

Detalhes bibliográficos
Autor(a) principal: Moura,Alexandre Sampaio
Data de Publicação: 2009
Outros Autores: Carmo,Ricardo Andrade, Teixeira,Antonio Lucio, Rocha,Manoel Otávio da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013
Resumo: Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.
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spelling Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis CHepatitis Cchemokinestumor necrosis factor receptorinterferon-alphaliver fibrosisHepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.Brazilian Society of Infectious Diseases2009-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013Brazilian Journal of Infectious Diseases v.13 n.5 2009reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702009000500013info:eu-repo/semantics/openAccessMoura,Alexandre SampaioCarmo,Ricardo AndradeTeixeira,Antonio LucioRocha,Manoel Otávio da Costaeng2010-04-14T00:00:00Zoai:scielo:S1413-86702009000500013Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2010-04-14T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
title Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
spellingShingle Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
Moura,Alexandre Sampaio
Hepatitis C
chemokines
tumor necrosis factor receptor
interferon-alpha
liver fibrosis
title_short Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
title_full Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
title_fullStr Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
title_full_unstemmed Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
title_sort Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
author Moura,Alexandre Sampaio
author_facet Moura,Alexandre Sampaio
Carmo,Ricardo Andrade
Teixeira,Antonio Lucio
Rocha,Manoel Otávio da Costa
author_role author
author2 Carmo,Ricardo Andrade
Teixeira,Antonio Lucio
Rocha,Manoel Otávio da Costa
author2_role author
author
author
dc.contributor.author.fl_str_mv Moura,Alexandre Sampaio
Carmo,Ricardo Andrade
Teixeira,Antonio Lucio
Rocha,Manoel Otávio da Costa
dc.subject.por.fl_str_mv Hepatitis C
chemokines
tumor necrosis factor receptor
interferon-alpha
liver fibrosis
topic Hepatitis C
chemokines
tumor necrosis factor receptor
interferon-alpha
liver fibrosis
description Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.
publishDate 2009
dc.date.none.fl_str_mv 2009-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702009000500013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.13 n.5 2009
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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