Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013 |
Resumo: | Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C. |
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Brazilian Journal of Infectious Diseases |
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Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis CHepatitis Cchemokinestumor necrosis factor receptorinterferon-alphaliver fibrosisHepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.Brazilian Society of Infectious Diseases2009-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013Brazilian Journal of Infectious Diseases v.13 n.5 2009reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702009000500013info:eu-repo/semantics/openAccessMoura,Alexandre SampaioCarmo,Ricardo AndradeTeixeira,Antonio LucioRocha,Manoel Otávio da Costaeng2010-04-14T00:00:00Zoai:scielo:S1413-86702009000500013Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2010-04-14T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
title |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
spellingShingle |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C Moura,Alexandre Sampaio Hepatitis C chemokines tumor necrosis factor receptor interferon-alpha liver fibrosis |
title_short |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
title_full |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
title_fullStr |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
title_full_unstemmed |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
title_sort |
Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C |
author |
Moura,Alexandre Sampaio |
author_facet |
Moura,Alexandre Sampaio Carmo,Ricardo Andrade Teixeira,Antonio Lucio Rocha,Manoel Otávio da Costa |
author_role |
author |
author2 |
Carmo,Ricardo Andrade Teixeira,Antonio Lucio Rocha,Manoel Otávio da Costa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Moura,Alexandre Sampaio Carmo,Ricardo Andrade Teixeira,Antonio Lucio Rocha,Manoel Otávio da Costa |
dc.subject.por.fl_str_mv |
Hepatitis C chemokines tumor necrosis factor receptor interferon-alpha liver fibrosis |
topic |
Hepatitis C chemokines tumor necrosis factor receptor interferon-alpha liver fibrosis |
description |
Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702009000500013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.13 n.5 2009 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209241082626048 |