Extensively drug-resistant tuberculosis: a case report and literature review

• Autor(a) principal: Araújo-Filho,João Alves de
• Data de Publicação: 2008
• Outros Autores: Vasconcelos-Jr,Arioldo Carvalho, Sousa,Eduardo Martins de, Silveira,Colombina da, Ribeiro,Elisangela, Kipnis,André, Junqueira-Kipnis,Ana Paula
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Infectious Diseases
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500019
• topic: Extensively drug-resistant tuberculosis; XDR-TB; tuberculosis; Mycobacterium tuberculosis

Extensively drug-resistant tuberculosis (XDR-TB) is an emerging health problem that threatens tuberculosis (TB) control worldwide, since suitable treatment for this disease has not yet been found. We report a case of secondary pulmonary XDR-TB in a 54-year-old, HIV-negative male from Goiânia, Brazil. The patient had long-standing pulmonary tuberculosis (nine years) with extensive bilateral lung damage and had been treated with multiple antituberculosis drugs (self-administered) before XDR-TB diagnosis. The strain of Mycobacterium tuberculosis was resistant to R- rifampicin, H-isoniazid, E-ethambutol, Eto-ethionamide, Ofx-ofloxacin, and Am-amikacin. This patient died with multiple organ failure due to sepsis secondary to bacterial pneumonia.