Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311 |
Resumo: | ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia. |
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Brazilian Journal of Infectious Diseases |
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Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphismHelicobacter pyloriDyspepsiaInterleukin-1betaPolymorphismInflammationABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.Brazilian Society of Infectious Diseases2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311Brazilian Journal of Infectious Diseases v.22 n.4 2018reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2018.06.005info:eu-repo/semantics/openAccessRech,Tássia FloresMazzoleni,Luiz EdmundoMazzoleni,FelipeFrancesconi,Carlos Fernando de MagalhãesSander,Guilherme BeckerMichita,Rafael TomoyaNabinger,Débora DreherMilbradt,Tobias CancianTorresini,Ronaldo João SpinatoSimon,Danieleng2018-10-09T00:00:00Zoai:scielo:S1413-86702018000400311Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2018-10-09T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
title |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
spellingShingle |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism Rech,Tássia Flores Helicobacter pylori Dyspepsia Interleukin-1beta Polymorphism Inflammation |
title_short |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
title_full |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
title_fullStr |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
title_full_unstemmed |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
title_sort |
Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism |
author |
Rech,Tássia Flores |
author_facet |
Rech,Tássia Flores Mazzoleni,Luiz Edmundo Mazzoleni,Felipe Francesconi,Carlos Fernando de Magalhães Sander,Guilherme Becker Michita,Rafael Tomoya Nabinger,Débora Dreher Milbradt,Tobias Cancian Torresini,Ronaldo João Spinato Simon,Daniel |
author_role |
author |
author2 |
Mazzoleni,Luiz Edmundo Mazzoleni,Felipe Francesconi,Carlos Fernando de Magalhães Sander,Guilherme Becker Michita,Rafael Tomoya Nabinger,Débora Dreher Milbradt,Tobias Cancian Torresini,Ronaldo João Spinato Simon,Daniel |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rech,Tássia Flores Mazzoleni,Luiz Edmundo Mazzoleni,Felipe Francesconi,Carlos Fernando de Magalhães Sander,Guilherme Becker Michita,Rafael Tomoya Nabinger,Débora Dreher Milbradt,Tobias Cancian Torresini,Ronaldo João Spinato Simon,Daniel |
dc.subject.por.fl_str_mv |
Helicobacter pylori Dyspepsia Interleukin-1beta Polymorphism Inflammation |
topic |
Helicobacter pylori Dyspepsia Interleukin-1beta Polymorphism Inflammation |
description |
ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2018.06.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.22 n.4 2018 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
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1754209244569141248 |