Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism

Detalhes bibliográficos
Autor(a) principal: Rech,Tássia Flores
Data de Publicação: 2018
Outros Autores: Mazzoleni,Luiz Edmundo, Mazzoleni,Felipe, Francesconi,Carlos Fernando de Magalhães, Sander,Guilherme Becker, Michita,Rafael Tomoya, Nabinger,Débora Dreher, Milbradt,Tobias Cancian, Torresini,Ronaldo João Spinato, Simon,Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311
Resumo: ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.
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spelling Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphismHelicobacter pyloriDyspepsiaInterleukin-1betaPolymorphismInflammationABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.Brazilian Society of Infectious Diseases2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311Brazilian Journal of Infectious Diseases v.22 n.4 2018reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2018.06.005info:eu-repo/semantics/openAccessRech,Tássia FloresMazzoleni,Luiz EdmundoMazzoleni,FelipeFrancesconi,Carlos Fernando de MagalhãesSander,Guilherme BeckerMichita,Rafael TomoyaNabinger,Débora DreherMilbradt,Tobias CancianTorresini,Ronaldo João SpinatoSimon,Danieleng2018-10-09T00:00:00Zoai:scielo:S1413-86702018000400311Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2018-10-09T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
title Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
spellingShingle Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
Rech,Tássia Flores
Helicobacter pylori
Dyspepsia
Interleukin-1beta
Polymorphism
Inflammation
title_short Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
title_full Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
title_fullStr Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
title_full_unstemmed Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
title_sort Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
author Rech,Tássia Flores
author_facet Rech,Tássia Flores
Mazzoleni,Luiz Edmundo
Mazzoleni,Felipe
Francesconi,Carlos Fernando de Magalhães
Sander,Guilherme Becker
Michita,Rafael Tomoya
Nabinger,Débora Dreher
Milbradt,Tobias Cancian
Torresini,Ronaldo João Spinato
Simon,Daniel
author_role author
author2 Mazzoleni,Luiz Edmundo
Mazzoleni,Felipe
Francesconi,Carlos Fernando de Magalhães
Sander,Guilherme Becker
Michita,Rafael Tomoya
Nabinger,Débora Dreher
Milbradt,Tobias Cancian
Torresini,Ronaldo João Spinato
Simon,Daniel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rech,Tássia Flores
Mazzoleni,Luiz Edmundo
Mazzoleni,Felipe
Francesconi,Carlos Fernando de Magalhães
Sander,Guilherme Becker
Michita,Rafael Tomoya
Nabinger,Débora Dreher
Milbradt,Tobias Cancian
Torresini,Ronaldo João Spinato
Simon,Daniel
dc.subject.por.fl_str_mv Helicobacter pylori
Dyspepsia
Interleukin-1beta
Polymorphism
Inflammation
topic Helicobacter pylori
Dyspepsia
Interleukin-1beta
Polymorphism
Inflammation
description ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2018.06.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.22 n.4 2018
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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