Prognostic significance of PD-L1 and PD-L2 in breast cancer
| Autor(a) principal: | |
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| Data de Publicação: | 2016 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
| Texto Completo: | https://hdl.handle.net/20.500.12733/1642281 |
Resumo: | Agradecimentos: This work was supported by a grant from FAPESP (Sao Paulo Research Foundation), |
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Prognostic significance of PD-L1 and PD-L2 in breast cancerNeoplasias da mamaBreast neoplasmsPrognosisBiomarkerSurvivalPD-L1PD-L2Artigo originalAgradecimentos: This work was supported by a grant from FAPESP (Sao Paulo Research Foundation),PD-L1 and PD-L2 constitute an important antitumor immune response. In breast cancer, their prognostic value is still to be defined. In this study, we investigate the correlation between PD-L1 and PD-L2 protein expressions with clinical and pathologic features and disease-free survival and overall survival. To assess PD-L1 and PD-L2 expressions, we conducted immunohistochemistry studies using a breast cancer tissue microarray encompassing a total of 192 breast cancer cases, stages I, II, and III, with detailed clinical and outcome data. PD-L1 expression was present in 56.6% (107/189), and PD-L2 expression was identified in 50.8% (97/191) of breast cancer cases. Younger age at diagnosis, lymph node positivity, negative estrogen receptor, and recurrence at distant sites were all associated with both PD-L1 and PD-L2 expressions. The presence of larger tumors was associated only with PD-L1 expression. In our study, PD-L1 expression was significantly associated with better overall survival (P = .04) in breast cancer patients. Despite its association with poor clinical and pathologic features, PD-L1 expression emerges as a positive prognostic biomarker in breast cancer. This survival result might be due to the presence of a strong antitumor immune response leading to PD-L1 expressionFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFechadoUNIVERSIDADE ESTADUAL DE CAMPINASBaptista, Mauricio Zuccolotto, 1975-Sarian, Luís Otávio Zanatta, 1974-Derchain, Sophie Françoise Mauricette, 1959-Pinto, Glauce AparecidaVassallo, José, 1957-2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/1642281BAPTISTA, Mauricio Zuccolotto et al. Prognostic significance of PD-L1 and PD-L2 in breast cancer. Human pathology. Philadelphia, PA : Elsevier, 2016.. Vol. 47, no. 1 (Jan., 2016), p. 78-84. Disponível em: https://hdl.handle.net/20.500.12733/1642281. Acesso em: 7 mai. 2024.https://repositorio.unicamp.br/acervo/detalhe/1170826porreponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2023-10-25T13:28:06Zoai:https://www.repositorio.unicamp.br/:1170826Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2023-10-25T13:28:06Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
| dc.title.none.fl_str_mv |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| title |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| spellingShingle |
Prognostic significance of PD-L1 and PD-L2 in breast cancer Baptista, Mauricio Zuccolotto, 1975- Neoplasias da mama Breast neoplasms Prognosis Biomarker Survival PD-L1 PD-L2 Artigo original |
| title_short |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| title_full |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| title_fullStr |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| title_full_unstemmed |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| title_sort |
Prognostic significance of PD-L1 and PD-L2 in breast cancer |
| author |
Baptista, Mauricio Zuccolotto, 1975- |
| author_facet |
Baptista, Mauricio Zuccolotto, 1975- Sarian, Luís Otávio Zanatta, 1974- Derchain, Sophie Françoise Mauricette, 1959- Pinto, Glauce Aparecida Vassallo, José, 1957- |
| author_role |
author |
| author2 |
Sarian, Luís Otávio Zanatta, 1974- Derchain, Sophie Françoise Mauricette, 1959- Pinto, Glauce Aparecida Vassallo, José, 1957- |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
| dc.contributor.author.fl_str_mv |
Baptista, Mauricio Zuccolotto, 1975- Sarian, Luís Otávio Zanatta, 1974- Derchain, Sophie Françoise Mauricette, 1959- Pinto, Glauce Aparecida Vassallo, José, 1957- |
| dc.subject.por.fl_str_mv |
Neoplasias da mama Breast neoplasms Prognosis Biomarker Survival PD-L1 PD-L2 Artigo original |
| topic |
Neoplasias da mama Breast neoplasms Prognosis Biomarker Survival PD-L1 PD-L2 Artigo original |
| description |
Agradecimentos: This work was supported by a grant from FAPESP (Sao Paulo Research Foundation), |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/1642281 BAPTISTA, Mauricio Zuccolotto et al. Prognostic significance of PD-L1 and PD-L2 in breast cancer. Human pathology. Philadelphia, PA : Elsevier, 2016.. Vol. 47, no. 1 (Jan., 2016), p. 78-84. Disponível em: https://hdl.handle.net/20.500.12733/1642281. Acesso em: 7 mai. 2024. |
| url |
https://hdl.handle.net/20.500.12733/1642281 |
| identifier_str_mv |
BAPTISTA, Mauricio Zuccolotto et al. Prognostic significance of PD-L1 and PD-L2 in breast cancer. Human pathology. Philadelphia, PA : Elsevier, 2016.. Vol. 47, no. 1 (Jan., 2016), p. 78-84. Disponível em: https://hdl.handle.net/20.500.12733/1642281. Acesso em: 7 mai. 2024. |
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por |
| language |
por |
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https://repositorio.unicamp.br/acervo/detalhe/1170826 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
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Universidade Estadual de Campinas (UNICAMP) |
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UNICAMP |
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UNICAMP |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
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reposip@unicamp.br |
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