Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000300154 |
Resumo: | ABSTRACT Objective: to evaluate the expression of the epithelial growth factor receptor (EGFR) by immunohistochemistry, and to verify its association with prognostic factors and survival of patients operated by cholangiocarcinoma. Methods: we verified the immunohistochemical expression of EGFR in 35 surgical specimens of cholangiocarcinoma (CCA). We obtained survival curves with the Kaplan-Meier method. Results: we found significant EGFR expression in ten (28.6%) of the 35 CCAs, eight with score 3 and two with score 2. Advanced stages (III and IV) presented higher EGFR expression (p=0.07). The clinical characteristics that were most associated with positive EGFR expression were female gender (p=0.06) and absence of comorbidities (p=0.06). Overall survival at 12, 24, 36 and 48 months was 100%, 82.5%, 59% and 44.2%, respectively. The survival of EGFR positive patients at 12, 24, 36 and 48 months was 100%, 75%, 50% and 0%, whereas for negative EGFR patients it was 100%, 87.5%, 65.6% and 65.6%, respectively. Conclusion: EGFR expression occurred in 28.6% of the cases studied and was associated with lower survival. |
id |
CBC-1_438aaf0a91268f3664aec2170b7bc684 |
---|---|
oai_identifier_str |
oai:scielo:S0100-69912018000300154 |
network_acronym_str |
CBC-1 |
network_name_str |
Revista do Colégio Brasileiro de Cirurgiões |
repository_id_str |
|
spelling |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survivalCholangiocarcinomaGenes, erbB-1PrognosisSurvival Analysis.ABSTRACT Objective: to evaluate the expression of the epithelial growth factor receptor (EGFR) by immunohistochemistry, and to verify its association with prognostic factors and survival of patients operated by cholangiocarcinoma. Methods: we verified the immunohistochemical expression of EGFR in 35 surgical specimens of cholangiocarcinoma (CCA). We obtained survival curves with the Kaplan-Meier method. Results: we found significant EGFR expression in ten (28.6%) of the 35 CCAs, eight with score 3 and two with score 2. Advanced stages (III and IV) presented higher EGFR expression (p=0.07). The clinical characteristics that were most associated with positive EGFR expression were female gender (p=0.06) and absence of comorbidities (p=0.06). Overall survival at 12, 24, 36 and 48 months was 100%, 82.5%, 59% and 44.2%, respectively. The survival of EGFR positive patients at 12, 24, 36 and 48 months was 100%, 75%, 50% and 0%, whereas for negative EGFR patients it was 100%, 87.5%, 65.6% and 65.6%, respectively. Conclusion: EGFR expression occurred in 28.6% of the cases studied and was associated with lower survival.Colégio Brasileiro de Cirurgiões2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000300154Revista do Colégio Brasileiro de Cirurgiões v.45 n.3 2018reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-6991e-20181826info:eu-repo/semantics/openAccessGOMES,RODRIGO VIEIRARODRIGUES,MICHELE ÂNGELARODRIGUES,JOÃO BERNARDO SANCIO ROCHAVIDIGAL,PAULA TEIXEIRADAMASCENO,KARINE ARAÚJOLIMA,HENRIQUE ARAÚJOGOMES,DAWIDSON ASSISMACHADO,CARLA JORGERESENDE,VIVIANeng2018-07-04T00:00:00Zoai:scielo:S0100-69912018000300154Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2018-07-04T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
title |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
spellingShingle |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival GOMES,RODRIGO VIEIRA Cholangiocarcinoma Genes, erbB-1 Prognosis Survival Analysis. |
title_short |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
title_full |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
title_fullStr |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
title_full_unstemmed |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
title_sort |
Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival |
author |
GOMES,RODRIGO VIEIRA |
author_facet |
GOMES,RODRIGO VIEIRA RODRIGUES,MICHELE ÂNGELA RODRIGUES,JOÃO BERNARDO SANCIO ROCHA VIDIGAL,PAULA TEIXEIRA DAMASCENO,KARINE ARAÚJO LIMA,HENRIQUE ARAÚJO GOMES,DAWIDSON ASSIS MACHADO,CARLA JORGE RESENDE,VIVIAN |
author_role |
author |
author2 |
RODRIGUES,MICHELE ÂNGELA RODRIGUES,JOÃO BERNARDO SANCIO ROCHA VIDIGAL,PAULA TEIXEIRA DAMASCENO,KARINE ARAÚJO LIMA,HENRIQUE ARAÚJO GOMES,DAWIDSON ASSIS MACHADO,CARLA JORGE RESENDE,VIVIAN |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
GOMES,RODRIGO VIEIRA RODRIGUES,MICHELE ÂNGELA RODRIGUES,JOÃO BERNARDO SANCIO ROCHA VIDIGAL,PAULA TEIXEIRA DAMASCENO,KARINE ARAÚJO LIMA,HENRIQUE ARAÚJO GOMES,DAWIDSON ASSIS MACHADO,CARLA JORGE RESENDE,VIVIAN |
dc.subject.por.fl_str_mv |
Cholangiocarcinoma Genes, erbB-1 Prognosis Survival Analysis. |
topic |
Cholangiocarcinoma Genes, erbB-1 Prognosis Survival Analysis. |
description |
ABSTRACT Objective: to evaluate the expression of the epithelial growth factor receptor (EGFR) by immunohistochemistry, and to verify its association with prognostic factors and survival of patients operated by cholangiocarcinoma. Methods: we verified the immunohistochemical expression of EGFR in 35 surgical specimens of cholangiocarcinoma (CCA). We obtained survival curves with the Kaplan-Meier method. Results: we found significant EGFR expression in ten (28.6%) of the 35 CCAs, eight with score 3 and two with score 2. Advanced stages (III and IV) presented higher EGFR expression (p=0.07). The clinical characteristics that were most associated with positive EGFR expression were female gender (p=0.06) and absence of comorbidities (p=0.06). Overall survival at 12, 24, 36 and 48 months was 100%, 82.5%, 59% and 44.2%, respectively. The survival of EGFR positive patients at 12, 24, 36 and 48 months was 100%, 75%, 50% and 0%, whereas for negative EGFR patients it was 100%, 87.5%, 65.6% and 65.6%, respectively. Conclusion: EGFR expression occurred in 28.6% of the cases studied and was associated with lower survival. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000300154 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912018000300154 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-6991e-20181826 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.45 n.3 2018 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
institution |
CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
repository.mail.fl_str_mv |
||revistacbc@cbc.org.br |
_version_ |
1754209214134222848 |