Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100190 |
Resumo: | ABSTRACT Objective: to evaluate the impact of probable sarcopenia (PS) on the survival of oncological patients submitted to major surgeries. Method: prospective cohort bicentrical study enrolling adult oncological patients submitted to major surgeries at Cancer Hospital and Santa Casa de Misericordia in Cuiabá-MT. The main endpoint was the verification of postoperative death. Demographic and clinical data was collected. PS was defined as the presence of 1) sarcopenia risk assessed by SARC-F questionnaire and 2) low muscle strength measured by dynamometry. The cumulative mortality rate was calculated for patients with either PS or non PS using Kaplan Meier curve. The univariate and multivariate Cox regression model was used to evaluate the association of mortality with various investigated confounding variables. Results: a total of 220 patients with a mean (SD) age of 58.7±14.0 years old, 60.5% males participated of the study. Patients with PS had higher risk to postoperative death (RR=5.35 95%CI 1.95-14.66; p=0,001) and for infectious complications (RR=2.45 95%CI 1.12-5.33; p=0.036). The 60 days mean survival was shorter for patients with PS: 44 (IQR=32-37) vs 58 (IQR=56-59) days (log rank <0,001). The Cox multivariate regression showed that PS was an independent risk factor (HR=5.8 95%CI 1.49-22.58; p=0.011) for mortality. Conclusion: patients bearing PS submitted to major oncological surgery have less probability of short term survival and preoperative PS is an independent risk for postoperative mortality. |
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Revista do Colégio Brasileiro de Cirurgiões |
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Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical proceduresSurgical OncologySarcopeniaMortalityPostoperative ComplicationsABSTRACT Objective: to evaluate the impact of probable sarcopenia (PS) on the survival of oncological patients submitted to major surgeries. Method: prospective cohort bicentrical study enrolling adult oncological patients submitted to major surgeries at Cancer Hospital and Santa Casa de Misericordia in Cuiabá-MT. The main endpoint was the verification of postoperative death. Demographic and clinical data was collected. PS was defined as the presence of 1) sarcopenia risk assessed by SARC-F questionnaire and 2) low muscle strength measured by dynamometry. The cumulative mortality rate was calculated for patients with either PS or non PS using Kaplan Meier curve. The univariate and multivariate Cox regression model was used to evaluate the association of mortality with various investigated confounding variables. Results: a total of 220 patients with a mean (SD) age of 58.7±14.0 years old, 60.5% males participated of the study. Patients with PS had higher risk to postoperative death (RR=5.35 95%CI 1.95-14.66; p=0,001) and for infectious complications (RR=2.45 95%CI 1.12-5.33; p=0.036). The 60 days mean survival was shorter for patients with PS: 44 (IQR=32-37) vs 58 (IQR=56-59) days (log rank <0,001). The Cox multivariate regression showed that PS was an independent risk factor (HR=5.8 95%CI 1.49-22.58; p=0.011) for mortality. Conclusion: patients bearing PS submitted to major oncological surgery have less probability of short term survival and preoperative PS is an independent risk for postoperative mortality.Colégio Brasileiro de Cirurgiões2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100190Revista do Colégio Brasileiro de Cirurgiões v.47 2020reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-6991e-20202528info:eu-repo/semantics/openAccessBEHNE,THAYSE EMANUELLI GODOYDOCK-NASIMENTO,DIANA BORGESSIERRA,JESSIKA CADAVIDRODRIGUES,HADASSA HILLARY NOVAES PEREIRAPALAURO,MARISTELA LUFTANDREO,FRANCILENE OLIVEIRASILVA-THE,MARIANA BORGESDE-AGUILAR-NASCIMENTO,JOSÉ EDUARDOeng2020-09-02T00:00:00Zoai:scielo:S0100-69912020000100190Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2020-09-02T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
title |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
spellingShingle |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures BEHNE,THAYSE EMANUELLI GODOY Surgical Oncology Sarcopenia Mortality Postoperative Complications |
title_short |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
title_full |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
title_fullStr |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
title_full_unstemmed |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
title_sort |
Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures |
author |
BEHNE,THAYSE EMANUELLI GODOY |
author_facet |
BEHNE,THAYSE EMANUELLI GODOY DOCK-NASIMENTO,DIANA BORGES SIERRA,JESSIKA CADAVID RODRIGUES,HADASSA HILLARY NOVAES PEREIRA PALAURO,MARISTELA LUFT ANDREO,FRANCILENE OLIVEIRA SILVA-THE,MARIANA BORGES DE-AGUILAR-NASCIMENTO,JOSÉ EDUARDO |
author_role |
author |
author2 |
DOCK-NASIMENTO,DIANA BORGES SIERRA,JESSIKA CADAVID RODRIGUES,HADASSA HILLARY NOVAES PEREIRA PALAURO,MARISTELA LUFT ANDREO,FRANCILENE OLIVEIRA SILVA-THE,MARIANA BORGES DE-AGUILAR-NASCIMENTO,JOSÉ EDUARDO |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
BEHNE,THAYSE EMANUELLI GODOY DOCK-NASIMENTO,DIANA BORGES SIERRA,JESSIKA CADAVID RODRIGUES,HADASSA HILLARY NOVAES PEREIRA PALAURO,MARISTELA LUFT ANDREO,FRANCILENE OLIVEIRA SILVA-THE,MARIANA BORGES DE-AGUILAR-NASCIMENTO,JOSÉ EDUARDO |
dc.subject.por.fl_str_mv |
Surgical Oncology Sarcopenia Mortality Postoperative Complications |
topic |
Surgical Oncology Sarcopenia Mortality Postoperative Complications |
description |
ABSTRACT Objective: to evaluate the impact of probable sarcopenia (PS) on the survival of oncological patients submitted to major surgeries. Method: prospective cohort bicentrical study enrolling adult oncological patients submitted to major surgeries at Cancer Hospital and Santa Casa de Misericordia in Cuiabá-MT. The main endpoint was the verification of postoperative death. Demographic and clinical data was collected. PS was defined as the presence of 1) sarcopenia risk assessed by SARC-F questionnaire and 2) low muscle strength measured by dynamometry. The cumulative mortality rate was calculated for patients with either PS or non PS using Kaplan Meier curve. The univariate and multivariate Cox regression model was used to evaluate the association of mortality with various investigated confounding variables. Results: a total of 220 patients with a mean (SD) age of 58.7±14.0 years old, 60.5% males participated of the study. Patients with PS had higher risk to postoperative death (RR=5.35 95%CI 1.95-14.66; p=0,001) and for infectious complications (RR=2.45 95%CI 1.12-5.33; p=0.036). The 60 days mean survival was shorter for patients with PS: 44 (IQR=32-37) vs 58 (IQR=56-59) days (log rank <0,001). The Cox multivariate regression showed that PS was an independent risk factor (HR=5.8 95%CI 1.49-22.58; p=0.011) for mortality. Conclusion: patients bearing PS submitted to major oncological surgery have less probability of short term survival and preoperative PS is an independent risk for postoperative mortality. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100190 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100190 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-6991e-20202528 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.47 2020 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
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CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
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1754209214962597888 |