Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206 |
Resumo: | ABSTRACT Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtained by the Division of Surgical Oncology of Erasto Gaertner Hospital. The sample was divided into Period 1 (1987-1997), Period 2 (1998-2003) and Period 3 (2007-2015). Survival rates and disease-free survival were estimated by the Kaplan-Maier method. Survival predictors were identified with Cox regression. ANOVA test was used for comparison between groups. Data were analyzed with SPSS 25.0 and STATA 16, and p<0.05 was considered statistically significant. Results: a total of 335 patients underwent esophagectomy or esophagogastrectomy. When the clinical characteristics of the 3 groups were compared, there was no statistically significant difference. Neoadjuvance was significantly higher in Period 3 (55.4% of patients). We found a histological change in the diagnosis over time, with a significant increase in adenocarcinoma. Morbidity and mortality rates were higher in Period 3. The main complications were pulmonary and anastomotic fistulas. Overall survival in 5 years increased over time, reaching 59.7% in Period 3. Conclusions: better neoadjuvant treatment contributed to increase the global survival of patients, despite greater rate of immediate complications to surgery. |
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Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single centerEsophageal NeoplasmsEsophagectomyPostoperative ComplicationsTreatment OutcomeABSTRACT Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtained by the Division of Surgical Oncology of Erasto Gaertner Hospital. The sample was divided into Period 1 (1987-1997), Period 2 (1998-2003) and Period 3 (2007-2015). Survival rates and disease-free survival were estimated by the Kaplan-Maier method. Survival predictors were identified with Cox regression. ANOVA test was used for comparison between groups. Data were analyzed with SPSS 25.0 and STATA 16, and p<0.05 was considered statistically significant. Results: a total of 335 patients underwent esophagectomy or esophagogastrectomy. When the clinical characteristics of the 3 groups were compared, there was no statistically significant difference. Neoadjuvance was significantly higher in Period 3 (55.4% of patients). We found a histological change in the diagnosis over time, with a significant increase in adenocarcinoma. Morbidity and mortality rates were higher in Period 3. The main complications were pulmonary and anastomotic fistulas. Overall survival in 5 years increased over time, reaching 59.7% in Period 3. Conclusions: better neoadjuvant treatment contributed to increase the global survival of patients, despite greater rate of immediate complications to surgery.Colégio Brasileiro de Cirurgiões2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206Revista do Colégio Brasileiro de Cirurgiões v.48 2021reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-6991e-20202723info:eu-repo/semantics/openAccessFERREIRA,RAPHAELLA PAULABUSSYGUIN,DANILO SAAVEDRATROMBETTA,HYGORMELO,VICTOR JOSE DORNELASXIMENEZ,DANIELE REZENDEPRETI,VINICIUS BASSOVALLADARES,GERARDO CRISTINO GAVARRETETOMASICH,FLAVIO DANIEL SAAVEDRAABREU,PHILLIPEeng2021-02-11T00:00:00Zoai:scielo:S0100-69912021000100206Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2021-02-11T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
title |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
spellingShingle |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center FERREIRA,RAPHAELLA PAULA Esophageal Neoplasms Esophagectomy Postoperative Complications Treatment Outcome |
title_short |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
title_full |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
title_fullStr |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
title_full_unstemmed |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
title_sort |
Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
author |
FERREIRA,RAPHAELLA PAULA |
author_facet |
FERREIRA,RAPHAELLA PAULA BUSSYGUIN,DANILO SAAVEDRA TROMBETTA,HYGOR MELO,VICTOR JOSE DORNELAS XIMENEZ,DANIELE REZENDE PRETI,VINICIUS BASSO VALLADARES,GERARDO CRISTINO GAVARRETE TOMASICH,FLAVIO DANIEL SAAVEDRA ABREU,PHILLIPE |
author_role |
author |
author2 |
BUSSYGUIN,DANILO SAAVEDRA TROMBETTA,HYGOR MELO,VICTOR JOSE DORNELAS XIMENEZ,DANIELE REZENDE PRETI,VINICIUS BASSO VALLADARES,GERARDO CRISTINO GAVARRETE TOMASICH,FLAVIO DANIEL SAAVEDRA ABREU,PHILLIPE |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
FERREIRA,RAPHAELLA PAULA BUSSYGUIN,DANILO SAAVEDRA TROMBETTA,HYGOR MELO,VICTOR JOSE DORNELAS XIMENEZ,DANIELE REZENDE PRETI,VINICIUS BASSO VALLADARES,GERARDO CRISTINO GAVARRETE TOMASICH,FLAVIO DANIEL SAAVEDRA ABREU,PHILLIPE |
dc.subject.por.fl_str_mv |
Esophageal Neoplasms Esophagectomy Postoperative Complications Treatment Outcome |
topic |
Esophageal Neoplasms Esophagectomy Postoperative Complications Treatment Outcome |
description |
ABSTRACT Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtained by the Division of Surgical Oncology of Erasto Gaertner Hospital. The sample was divided into Period 1 (1987-1997), Period 2 (1998-2003) and Period 3 (2007-2015). Survival rates and disease-free survival were estimated by the Kaplan-Maier method. Survival predictors were identified with Cox regression. ANOVA test was used for comparison between groups. Data were analyzed with SPSS 25.0 and STATA 16, and p<0.05 was considered statistically significant. Results: a total of 335 patients underwent esophagectomy or esophagogastrectomy. When the clinical characteristics of the 3 groups were compared, there was no statistically significant difference. Neoadjuvance was significantly higher in Period 3 (55.4% of patients). We found a histological change in the diagnosis over time, with a significant increase in adenocarcinoma. Morbidity and mortality rates were higher in Period 3. The main complications were pulmonary and anastomotic fistulas. Overall survival in 5 years increased over time, reaching 59.7% in Period 3. Conclusions: better neoadjuvant treatment contributed to increase the global survival of patients, despite greater rate of immediate complications to surgery. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-6991e-20202723 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.48 2021 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
institution |
CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
repository.mail.fl_str_mv |
||revistacbc@cbc.org.br |
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1754209215061164032 |