Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer

Detalhes bibliográficos
Autor(a) principal: LUSTOSA,ROBERTO JOSÉ COSTA
Data de Publicação: 2020
Outros Autores: BATISTA,THALES PAULO, CARNEIRO,VANDRÉ CABRAL GOMES, BADIGLIAN-FILHO,LEVON, COSTA,RONALDO LÚCIO RANGEL, LOPES,ANDRÉ, SARMENTO,BRUNO JOSÉ DE QUEIROZ, LIMA,JUREMA TELLES DE OLIVEIRA, MELLO,MARIA JULIA GONÇALVES DE, LEÃO,CRISTIANO SOUZA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Colégio Brasileiro de Cirurgiões
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100184
Resumo: ABSTRACT Introduction: to evaluate the effect of short-course (i.e.: 30 minutes) HIPEC on health-related quality of life (HRQoL) in our feasibility study; NCT02249013. Methods: a prespecified secondary end-point of our open-label, multicenter, single-arm, phase 2 trial on safety and efficacy was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30, version 3.0). Patients were required to complete the HRQoL questionnaire at baseline, after HIPEC, and after the end of the treatment. Changes of HRQoL over time were assessed by median scores for each domain and analyzed by Friedman`s test at a significant two-sided level of 0.05. Results: fifteen patients with high tumor burden EOC were recruited from our public health system between February 2015 and July 2019. A baseline EORTC QLQ-C30 questionnaire and at least one follow-up questionnaire was received from all of the patients. No significant difference over time in the QLQC30 summary scores was observed (p>0.05). The transitory impairment on patients HRQoL immediately after the short-course HIPEC trended to return to baseline at the end of the multimodal treatment. Conclusions: we found no significant impairment of short-course HIPEC on patients HRQoL into the context of our comprehensive treatment protocol.
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spelling Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancerInjections IntraperitonealHyperthermia, InducedDrug TherapyPeritoneal NeoplasmsSurgical Procedures, OperativeABSTRACT Introduction: to evaluate the effect of short-course (i.e.: 30 minutes) HIPEC on health-related quality of life (HRQoL) in our feasibility study; NCT02249013. Methods: a prespecified secondary end-point of our open-label, multicenter, single-arm, phase 2 trial on safety and efficacy was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30, version 3.0). Patients were required to complete the HRQoL questionnaire at baseline, after HIPEC, and after the end of the treatment. Changes of HRQoL over time were assessed by median scores for each domain and analyzed by Friedman`s test at a significant two-sided level of 0.05. Results: fifteen patients with high tumor burden EOC were recruited from our public health system between February 2015 and July 2019. A baseline EORTC QLQ-C30 questionnaire and at least one follow-up questionnaire was received from all of the patients. No significant difference over time in the QLQC30 summary scores was observed (p>0.05). The transitory impairment on patients HRQoL immediately after the short-course HIPEC trended to return to baseline at the end of the multimodal treatment. Conclusions: we found no significant impairment of short-course HIPEC on patients HRQoL into the context of our comprehensive treatment protocol.Colégio Brasileiro de Cirurgiões2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100184Revista do Colégio Brasileiro de Cirurgiões v.47 2020reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-6991e-20202534info:eu-repo/semantics/openAccessLUSTOSA,ROBERTO JOSÉ COSTABATISTA,THALES PAULOCARNEIRO,VANDRÉ CABRAL GOMESBADIGLIAN-FILHO,LEVONCOSTA,RONALDO LÚCIO RANGELLOPES,ANDRÉSARMENTO,BRUNO JOSÉ DE QUEIROZLIMA,JUREMA TELLES DE OLIVEIRAMELLO,MARIA JULIA GONÇALVES DELEÃO,CRISTIANO SOUZAeng2020-08-10T00:00:00Zoai:scielo:S0100-69912020000100184Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2020-08-10T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false
dc.title.none.fl_str_mv Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
title Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
spellingShingle Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
LUSTOSA,ROBERTO JOSÉ COSTA
Injections Intraperitoneal
Hyperthermia, Induced
Drug Therapy
Peritoneal Neoplasms
Surgical Procedures, Operative
title_short Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
title_full Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
title_fullStr Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
title_full_unstemmed Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
title_sort Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer
author LUSTOSA,ROBERTO JOSÉ COSTA
author_facet LUSTOSA,ROBERTO JOSÉ COSTA
BATISTA,THALES PAULO
CARNEIRO,VANDRÉ CABRAL GOMES
BADIGLIAN-FILHO,LEVON
COSTA,RONALDO LÚCIO RANGEL
LOPES,ANDRÉ
SARMENTO,BRUNO JOSÉ DE QUEIROZ
LIMA,JUREMA TELLES DE OLIVEIRA
MELLO,MARIA JULIA GONÇALVES DE
LEÃO,CRISTIANO SOUZA
author_role author
author2 BATISTA,THALES PAULO
CARNEIRO,VANDRÉ CABRAL GOMES
BADIGLIAN-FILHO,LEVON
COSTA,RONALDO LÚCIO RANGEL
LOPES,ANDRÉ
SARMENTO,BRUNO JOSÉ DE QUEIROZ
LIMA,JUREMA TELLES DE OLIVEIRA
MELLO,MARIA JULIA GONÇALVES DE
LEÃO,CRISTIANO SOUZA
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv LUSTOSA,ROBERTO JOSÉ COSTA
BATISTA,THALES PAULO
CARNEIRO,VANDRÉ CABRAL GOMES
BADIGLIAN-FILHO,LEVON
COSTA,RONALDO LÚCIO RANGEL
LOPES,ANDRÉ
SARMENTO,BRUNO JOSÉ DE QUEIROZ
LIMA,JUREMA TELLES DE OLIVEIRA
MELLO,MARIA JULIA GONÇALVES DE
LEÃO,CRISTIANO SOUZA
dc.subject.por.fl_str_mv Injections Intraperitoneal
Hyperthermia, Induced
Drug Therapy
Peritoneal Neoplasms
Surgical Procedures, Operative
topic Injections Intraperitoneal
Hyperthermia, Induced
Drug Therapy
Peritoneal Neoplasms
Surgical Procedures, Operative
description ABSTRACT Introduction: to evaluate the effect of short-course (i.e.: 30 minutes) HIPEC on health-related quality of life (HRQoL) in our feasibility study; NCT02249013. Methods: a prespecified secondary end-point of our open-label, multicenter, single-arm, phase 2 trial on safety and efficacy was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30, version 3.0). Patients were required to complete the HRQoL questionnaire at baseline, after HIPEC, and after the end of the treatment. Changes of HRQoL over time were assessed by median scores for each domain and analyzed by Friedman`s test at a significant two-sided level of 0.05. Results: fifteen patients with high tumor burden EOC were recruited from our public health system between February 2015 and July 2019. A baseline EORTC QLQ-C30 questionnaire and at least one follow-up questionnaire was received from all of the patients. No significant difference over time in the QLQC30 summary scores was observed (p>0.05). The transitory impairment on patients HRQoL immediately after the short-course HIPEC trended to return to baseline at the end of the multimodal treatment. Conclusions: we found no significant impairment of short-course HIPEC on patients HRQoL into the context of our comprehensive treatment protocol.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100184
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912020000100184
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0100-6991e-20202534
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgiões
dc.source.none.fl_str_mv Revista do Colégio Brasileiro de Cirurgiões v.47 2020
reponame:Revista do Colégio Brasileiro de Cirurgiões
instname:Colégio Brasileiro de Cirurgiões (CBC)
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reponame_str Revista do Colégio Brasileiro de Cirurgiões
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