Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301 |
Resumo: | ABSTRACT Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period. Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration. Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated. Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats. Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice. |
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ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) |
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Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in ratsHepatectomyHematocritLiverBloodless medical and surgical proceduresABSTRACT Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period. Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration. Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated. Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats. Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice.Colégio Brasileiro de Cirurgia Digestiva2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.33 n.1 2020reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD)instacron:CBCD10.1590/0102-672020190001e1info:eu-repo/semantics/openAccessMALINOWSKI,Eduardo AugustusMATIAS,Jorge Eduardo FoutoPERCICOTE,Ana PaulaNAKADOMARI,ThaísaROBES,RogérioPETTERLE,Ricardo RasmussenNORONHA,Lúcia DeGODOY,Jose Luiz Deeng2020-03-26T00:00:00Zoai:scielo:S0102-67202020000100301Revistahttp://abarriguda.org.br/revista/index.php/revistaabarrigudaarepb/indexONGhttps://old.scielo.br/oai/scielo-oai.php||revistaabcd@gmail.com2317-63262317-6326opendoar:2020-03-26T00:00ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD)false |
dc.title.none.fl_str_mv |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
title |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
spellingShingle |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats MALINOWSKI,Eduardo Augustus Hepatectomy Hematocrit Liver Bloodless medical and surgical procedures |
title_short |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
title_full |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
title_fullStr |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
title_full_unstemmed |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
title_sort |
Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats |
author |
MALINOWSKI,Eduardo Augustus |
author_facet |
MALINOWSKI,Eduardo Augustus MATIAS,Jorge Eduardo Fouto PERCICOTE,Ana Paula NAKADOMARI,Thaísa ROBES,Rogério PETTERLE,Ricardo Rasmussen NORONHA,Lúcia De GODOY,Jose Luiz De |
author_role |
author |
author2 |
MATIAS,Jorge Eduardo Fouto PERCICOTE,Ana Paula NAKADOMARI,Thaísa ROBES,Rogério PETTERLE,Ricardo Rasmussen NORONHA,Lúcia De GODOY,Jose Luiz De |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
MALINOWSKI,Eduardo Augustus MATIAS,Jorge Eduardo Fouto PERCICOTE,Ana Paula NAKADOMARI,Thaísa ROBES,Rogério PETTERLE,Ricardo Rasmussen NORONHA,Lúcia De GODOY,Jose Luiz De |
dc.subject.por.fl_str_mv |
Hepatectomy Hematocrit Liver Bloodless medical and surgical procedures |
topic |
Hepatectomy Hematocrit Liver Bloodless medical and surgical procedures |
description |
ABSTRACT Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period. Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration. Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated. Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats. Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0102-672020190001e1 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgia Digestiva |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgia Digestiva |
dc.source.none.fl_str_mv |
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.33 n.1 2020 reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD) instacron:CBCD |
instname_str |
Colégio Brasileiro de Cirurgia Digestiva (CBCD) |
instacron_str |
CBCD |
institution |
CBCD |
reponame_str |
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) |
collection |
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) |
repository.name.fl_str_mv |
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD) |
repository.mail.fl_str_mv |
||revistaabcd@gmail.com |
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1754208958747246592 |