Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats

Detalhes bibliográficos
Autor(a) principal: MALINOWSKI,Eduardo Augustus
Data de Publicação: 2020
Outros Autores: MATIAS,Jorge Eduardo Fouto, PERCICOTE,Ana Paula, NAKADOMARI,Thaísa, ROBES,Rogério, PETTERLE,Ricardo Rasmussen, NORONHA,Lúcia De, GODOY,Jose Luiz De
Tipo de documento: Artigo
Idioma: eng
Título da fonte: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301
Resumo: ABSTRACT Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period. Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration. Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated. Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats. Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice.
id CBCD-1_44f4d6d557ad320191104460d798a148
oai_identifier_str oai:scielo:S0102-67202020000100301
network_acronym_str CBCD-1
network_name_str ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
repository_id_str
spelling Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in ratsHepatectomyHematocritLiverBloodless medical and surgical proceduresABSTRACT Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period. Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration. Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated. Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats. Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice.Colégio Brasileiro de Cirurgia Digestiva2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.33 n.1 2020reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD)instacron:CBCD10.1590/0102-672020190001e1info:eu-repo/semantics/openAccessMALINOWSKI,Eduardo AugustusMATIAS,Jorge Eduardo FoutoPERCICOTE,Ana PaulaNAKADOMARI,ThaísaROBES,RogérioPETTERLE,Ricardo RasmussenNORONHA,Lúcia DeGODOY,Jose Luiz Deeng2020-03-26T00:00:00Zoai:scielo:S0102-67202020000100301Revistahttp://abarriguda.org.br/revista/index.php/revistaabarrigudaarepb/indexONGhttps://old.scielo.br/oai/scielo-oai.php||revistaabcd@gmail.com2317-63262317-6326opendoar:2020-03-26T00:00ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD)false
dc.title.none.fl_str_mv Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
title Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
spellingShingle Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
MALINOWSKI,Eduardo Augustus
Hepatectomy
Hematocrit
Liver
Bloodless medical and surgical procedures
title_short Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
title_full Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
title_fullStr Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
title_full_unstemmed Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
title_sort Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats
author MALINOWSKI,Eduardo Augustus
author_facet MALINOWSKI,Eduardo Augustus
MATIAS,Jorge Eduardo Fouto
PERCICOTE,Ana Paula
NAKADOMARI,Thaísa
ROBES,Rogério
PETTERLE,Ricardo Rasmussen
NORONHA,Lúcia De
GODOY,Jose Luiz De
author_role author
author2 MATIAS,Jorge Eduardo Fouto
PERCICOTE,Ana Paula
NAKADOMARI,Thaísa
ROBES,Rogério
PETTERLE,Ricardo Rasmussen
NORONHA,Lúcia De
GODOY,Jose Luiz De
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv MALINOWSKI,Eduardo Augustus
MATIAS,Jorge Eduardo Fouto
PERCICOTE,Ana Paula
NAKADOMARI,Thaísa
ROBES,Rogério
PETTERLE,Ricardo Rasmussen
NORONHA,Lúcia De
GODOY,Jose Luiz De
dc.subject.por.fl_str_mv Hepatectomy
Hematocrit
Liver
Bloodless medical and surgical procedures
topic Hepatectomy
Hematocrit
Liver
Bloodless medical and surgical procedures
description ABSTRACT Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period. Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration. Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated. Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats. Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202020000100301
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0102-672020190001e1
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgia Digestiva
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgia Digestiva
dc.source.none.fl_str_mv ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.33 n.1 2020
reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD)
instacron:CBCD
instname_str Colégio Brasileiro de Cirurgia Digestiva (CBCD)
instacron_str CBCD
institution CBCD
reponame_str ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
collection ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
repository.name.fl_str_mv ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD)
repository.mail.fl_str_mv ||revistaabcd@gmail.com
_version_ 1754208958747246592