Relationship between actinic keratosis and malignant skin lesions on the eyelid

Detalhes bibliográficos
Autor(a) principal: Rossato,Luiz Angelo
Data de Publicação: 2022
Outros Autores: Carneiro,Rachel Camargo, Macedo,Erick Marcet Santiago de, Lima,Patricia Picciarelli de, Urbano,Mariana Ragassi, Matayoshi,Suzana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492022005002220
Resumo: ABSTRACT Purpose: To evaluate the variables possibly related to actinic keratosis and malignant skin lesions on the eyelid. Methods: A prospective study of patients with suspected eyelid malignancy was conducted. The participants underwent a 2-mm punch biopsy at two opposite sites of the lesion for diagnosis, and the results were compared with those of the histopathological study of the surgical excised specimen. The patients with an actinic keratosis component were divided into two groups (actinic keratosis-associated malignancy and actinic keratosis alone), which were compared for the following variables: age, disease duration, largest diameter, tumor area, Fitzpatrick classification, sex, tumor site and margin involvement. A cluster analysis was also performed. Results: We analyzed 174 lesions, of which 50 had an actinic keratosis component. Actinic keratosis was associated with squamous cell carcinoma in 22% of the cases and to basal cell carcinoma in 38%, which shows that both neoplasms may have contiguous actinic keratosis. Statistical analysis revealed no significant difference among the variables. In a cluster analysis, four groups were identified with malignant lesions in the medial canthus with the largest mean diameter and area. All margin involvements on the lower eyelid were related to malignancy, which means that all cases with margin involvement had an almost 100% risk of malignancy. Conclusions: Larger actinic keratosis lesions in the medial canthus and lesions with margin involvement on the lower eyelid have a greater probability of malignant association.
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spelling Relationship between actinic keratosis and malignant skin lesions on the eyelidKeratosis, actinic/pathologyBiopsyEyelid neoplasmsEyelids/injuriesABSTRACT Purpose: To evaluate the variables possibly related to actinic keratosis and malignant skin lesions on the eyelid. Methods: A prospective study of patients with suspected eyelid malignancy was conducted. The participants underwent a 2-mm punch biopsy at two opposite sites of the lesion for diagnosis, and the results were compared with those of the histopathological study of the surgical excised specimen. The patients with an actinic keratosis component were divided into two groups (actinic keratosis-associated malignancy and actinic keratosis alone), which were compared for the following variables: age, disease duration, largest diameter, tumor area, Fitzpatrick classification, sex, tumor site and margin involvement. A cluster analysis was also performed. Results: We analyzed 174 lesions, of which 50 had an actinic keratosis component. Actinic keratosis was associated with squamous cell carcinoma in 22% of the cases and to basal cell carcinoma in 38%, which shows that both neoplasms may have contiguous actinic keratosis. Statistical analysis revealed no significant difference among the variables. In a cluster analysis, four groups were identified with malignant lesions in the medial canthus with the largest mean diameter and area. All margin involvements on the lower eyelid were related to malignancy, which means that all cases with margin involvement had an almost 100% risk of malignancy. Conclusions: Larger actinic keratosis lesions in the medial canthus and lesions with margin involvement on the lower eyelid have a greater probability of malignant association.Conselho Brasileiro de Oftalmologia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492022005002220Arquivos Brasileiros de Oftalmologia n.ahead 2022reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20230002info:eu-repo/semantics/openAccessRossato,Luiz AngeloCarneiro,Rachel CamargoMacedo,Erick Marcet Santiago deLima,Patricia Picciarelli deUrbano,Mariana RagassiMatayoshi,Suzanaeng2022-02-11T00:00:00Zoai:scielo:S0004-27492022005002220Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2022-02-11T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Relationship between actinic keratosis and malignant skin lesions on the eyelid
title Relationship between actinic keratosis and malignant skin lesions on the eyelid
spellingShingle Relationship between actinic keratosis and malignant skin lesions on the eyelid
Rossato,Luiz Angelo
Keratosis, actinic/pathology
Biopsy
Eyelid neoplasms
Eyelids/injuries
title_short Relationship between actinic keratosis and malignant skin lesions on the eyelid
title_full Relationship between actinic keratosis and malignant skin lesions on the eyelid
title_fullStr Relationship between actinic keratosis and malignant skin lesions on the eyelid
title_full_unstemmed Relationship between actinic keratosis and malignant skin lesions on the eyelid
title_sort Relationship between actinic keratosis and malignant skin lesions on the eyelid
author Rossato,Luiz Angelo
author_facet Rossato,Luiz Angelo
Carneiro,Rachel Camargo
Macedo,Erick Marcet Santiago de
Lima,Patricia Picciarelli de
Urbano,Mariana Ragassi
Matayoshi,Suzana
author_role author
author2 Carneiro,Rachel Camargo
Macedo,Erick Marcet Santiago de
Lima,Patricia Picciarelli de
Urbano,Mariana Ragassi
Matayoshi,Suzana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rossato,Luiz Angelo
Carneiro,Rachel Camargo
Macedo,Erick Marcet Santiago de
Lima,Patricia Picciarelli de
Urbano,Mariana Ragassi
Matayoshi,Suzana
dc.subject.por.fl_str_mv Keratosis, actinic/pathology
Biopsy
Eyelid neoplasms
Eyelids/injuries
topic Keratosis, actinic/pathology
Biopsy
Eyelid neoplasms
Eyelids/injuries
description ABSTRACT Purpose: To evaluate the variables possibly related to actinic keratosis and malignant skin lesions on the eyelid. Methods: A prospective study of patients with suspected eyelid malignancy was conducted. The participants underwent a 2-mm punch biopsy at two opposite sites of the lesion for diagnosis, and the results were compared with those of the histopathological study of the surgical excised specimen. The patients with an actinic keratosis component were divided into two groups (actinic keratosis-associated malignancy and actinic keratosis alone), which were compared for the following variables: age, disease duration, largest diameter, tumor area, Fitzpatrick classification, sex, tumor site and margin involvement. A cluster analysis was also performed. Results: We analyzed 174 lesions, of which 50 had an actinic keratosis component. Actinic keratosis was associated with squamous cell carcinoma in 22% of the cases and to basal cell carcinoma in 38%, which shows that both neoplasms may have contiguous actinic keratosis. Statistical analysis revealed no significant difference among the variables. In a cluster analysis, four groups were identified with malignant lesions in the medial canthus with the largest mean diameter and area. All margin involvements on the lower eyelid were related to malignancy, which means that all cases with margin involvement had an almost 100% risk of malignancy. Conclusions: Larger actinic keratosis lesions in the medial canthus and lesions with margin involvement on the lower eyelid have a greater probability of malignant association.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492022005002220
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492022005002220
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.5935/0004-2749.20230002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia n.ahead 2022
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
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reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
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