Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004 |
Resumo: | PURPOSE: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. METHODS: A retrospective observational chart review was performed with 403 patients referred to a tertiary level hospital, each with a diagnosis of primary open-angle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. RESULTS: Thirty-one patients became blind [13/53 (24.5%) - unilaterally and 18/53 (34%) - bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persistency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. CONCLUSION: Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma. |
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Arquivos brasileiros de oftalmologia (Online) |
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Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 yearsGlaucoma, open-angle/complicationsBlindness/etiologyOptic disk/physiopathologyGlaucoma, open-angle/therapyVisual acuityRisk FactorsPURPOSE: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. METHODS: A retrospective observational chart review was performed with 403 patients referred to a tertiary level hospital, each with a diagnosis of primary open-angle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. RESULTS: Thirty-one patients became blind [13/53 (24.5%) - unilaterally and 18/53 (34%) - bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persistency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. CONCLUSION: Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma.Conselho Brasileiro de Oftalmologia2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004Arquivos Brasileiros de Oftalmologia v.75 n.4 2012reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492012000400004info:eu-repo/semantics/openAccessPaula,Jayter SilvaFurtado,João MarcelloSantos,Arles SilvaCoelho,Roberto de MattosRocha,Eduardo MelaniRodrigues,Maria de Lourdes Veroneseeng2012-12-17T00:00:00Zoai:scielo:S0004-27492012000400004Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2012-12-17T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
title |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
spellingShingle |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years Paula,Jayter Silva Glaucoma, open-angle/complications Blindness/etiology Optic disk/physiopathology Glaucoma, open-angle/therapy Visual acuity Risk Factors |
title_short |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
title_full |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
title_fullStr |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
title_full_unstemmed |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
title_sort |
Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years |
author |
Paula,Jayter Silva |
author_facet |
Paula,Jayter Silva Furtado,João Marcello Santos,Arles Silva Coelho,Roberto de Mattos Rocha,Eduardo Melani Rodrigues,Maria de Lourdes Veronese |
author_role |
author |
author2 |
Furtado,João Marcello Santos,Arles Silva Coelho,Roberto de Mattos Rocha,Eduardo Melani Rodrigues,Maria de Lourdes Veronese |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Paula,Jayter Silva Furtado,João Marcello Santos,Arles Silva Coelho,Roberto de Mattos Rocha,Eduardo Melani Rodrigues,Maria de Lourdes Veronese |
dc.subject.por.fl_str_mv |
Glaucoma, open-angle/complications Blindness/etiology Optic disk/physiopathology Glaucoma, open-angle/therapy Visual acuity Risk Factors |
topic |
Glaucoma, open-angle/complications Blindness/etiology Optic disk/physiopathology Glaucoma, open-angle/therapy Visual acuity Risk Factors |
description |
PURPOSE: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. METHODS: A retrospective observational chart review was performed with 403 patients referred to a tertiary level hospital, each with a diagnosis of primary open-angle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. RESULTS: Thirty-one patients became blind [13/53 (24.5%) - unilaterally and 18/53 (34%) - bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persistency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. CONCLUSION: Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492012000400004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.75 n.4 2012 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209027292659712 |