Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years

Detalhes bibliográficos
Autor(a) principal: Paula,Jayter Silva
Data de Publicação: 2012
Outros Autores: Furtado,João Marcello, Santos,Arles Silva, Coelho,Roberto de Mattos, Rocha,Eduardo Melani, Rodrigues,Maria de Lourdes Veronese
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004
Resumo: PURPOSE: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. METHODS: A retrospective observational chart review was performed with 403 patients referred to a tertiary level hospital, each with a diagnosis of primary open-angle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. RESULTS: Thirty-one patients became blind [13/53 (24.5%) - unilaterally and 18/53 (34%) - bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persistency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. CONCLUSION: Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma.
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spelling Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 yearsGlaucoma, open-angle/complicationsBlindness/etiologyOptic disk/physiopathologyGlaucoma, open-angle/therapyVisual acuityRisk FactorsPURPOSE: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. METHODS: A retrospective observational chart review was performed with 403 patients referred to a tertiary level hospital, each with a diagnosis of primary open-angle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. RESULTS: Thirty-one patients became blind [13/53 (24.5%) - unilaterally and 18/53 (34%) - bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persistency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. CONCLUSION: Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma.Conselho Brasileiro de Oftalmologia2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004Arquivos Brasileiros de Oftalmologia v.75 n.4 2012reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492012000400004info:eu-repo/semantics/openAccessPaula,Jayter SilvaFurtado,João MarcelloSantos,Arles SilvaCoelho,Roberto de MattosRocha,Eduardo MelaniRodrigues,Maria de Lourdes Veroneseeng2012-12-17T00:00:00Zoai:scielo:S0004-27492012000400004Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2012-12-17T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
title Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
spellingShingle Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
Paula,Jayter Silva
Glaucoma, open-angle/complications
Blindness/etiology
Optic disk/physiopathology
Glaucoma, open-angle/therapy
Visual acuity
Risk Factors
title_short Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
title_full Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
title_fullStr Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
title_full_unstemmed Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
title_sort Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years
author Paula,Jayter Silva
author_facet Paula,Jayter Silva
Furtado,João Marcello
Santos,Arles Silva
Coelho,Roberto de Mattos
Rocha,Eduardo Melani
Rodrigues,Maria de Lourdes Veronese
author_role author
author2 Furtado,João Marcello
Santos,Arles Silva
Coelho,Roberto de Mattos
Rocha,Eduardo Melani
Rodrigues,Maria de Lourdes Veronese
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Paula,Jayter Silva
Furtado,João Marcello
Santos,Arles Silva
Coelho,Roberto de Mattos
Rocha,Eduardo Melani
Rodrigues,Maria de Lourdes Veronese
dc.subject.por.fl_str_mv Glaucoma, open-angle/complications
Blindness/etiology
Optic disk/physiopathology
Glaucoma, open-angle/therapy
Visual acuity
Risk Factors
topic Glaucoma, open-angle/complications
Blindness/etiology
Optic disk/physiopathology
Glaucoma, open-angle/therapy
Visual acuity
Risk Factors
description PURPOSE: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. METHODS: A retrospective observational chart review was performed with 403 patients referred to a tertiary level hospital, each with a diagnosis of primary open-angle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. RESULTS: Thirty-one patients became blind [13/53 (24.5%) - unilaterally and 18/53 (34%) - bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persistency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. CONCLUSION: Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000400004
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492012000400004
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.75 n.4 2012
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
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institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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