Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000500018 |
Resumo: | PURPOSE: To determine whether there is a circadian change of the concentration of C-type natriuretic peptide (CNP) in rabbit aqueous humor. METHODS: Forty-one male white New Zealand rabbits were submitted to a 12 h light and 12 dark lighting schedule; lights on was at 0 h, lights off at 12 h. C-type natriuretic peptide was assayed at 3 light (2 h, 6 h and 10 h) and 3 dark (14,18 and 22 h) times. All groups consisted of four animals but two had more animals to increase the power of tests (6 h, n=12; 22 h, n=13). Dependence between the two eyes was tested by Pearson's correlation. The mean of two eyes was considered for analysis. Differences in concentration in pg/200 ml were evaluated by one-way ANOVA, t test and COSINOR analysis. RESULTS: There were no significant differences between the 6 analyzed groups (one-way ANOVA p=0.157). Pooled into two groups (light and dark), the C-type natriuretic peptide concentration of the light group was lower, 2.626±0.92 pg/200 ml compared with the dark group 3.02±1.16 pg/200 ml but did not reach a significant difference (t test; p=0.23). COSINOR analysis was not statistically significant (R%=7.72 p=0.209). CONCLUSION: These data demonstrate that the concentration of CNP in aqueous humor did not show a statistically significant circadian change in rabbits entrained to a 12 h light: 12 h dark lighting schedule. |
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Arquivos brasileiros de oftalmologia (Online) |
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Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humorNatriuretic agentsCyclic GMPAqueous humorIntraocular pressureOcular physiology/drug effectsGlaucomaNatriuretic peptideC-typeCircadian rhythmRabbitsPURPOSE: To determine whether there is a circadian change of the concentration of C-type natriuretic peptide (CNP) in rabbit aqueous humor. METHODS: Forty-one male white New Zealand rabbits were submitted to a 12 h light and 12 dark lighting schedule; lights on was at 0 h, lights off at 12 h. C-type natriuretic peptide was assayed at 3 light (2 h, 6 h and 10 h) and 3 dark (14,18 and 22 h) times. All groups consisted of four animals but two had more animals to increase the power of tests (6 h, n=12; 22 h, n=13). Dependence between the two eyes was tested by Pearson's correlation. The mean of two eyes was considered for analysis. Differences in concentration in pg/200 ml were evaluated by one-way ANOVA, t test and COSINOR analysis. RESULTS: There were no significant differences between the 6 analyzed groups (one-way ANOVA p=0.157). Pooled into two groups (light and dark), the C-type natriuretic peptide concentration of the light group was lower, 2.626±0.92 pg/200 ml compared with the dark group 3.02±1.16 pg/200 ml but did not reach a significant difference (t test; p=0.23). COSINOR analysis was not statistically significant (R%=7.72 p=0.209). CONCLUSION: These data demonstrate that the concentration of CNP in aqueous humor did not show a statistically significant circadian change in rabbits entrained to a 12 h light: 12 h dark lighting schedule.Conselho Brasileiro de Oftalmologia2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000500018Arquivos Brasileiros de Oftalmologia v.69 n.5 2006reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492006000500018info:eu-repo/semantics/openAccessParanhos Jr.,AugustoOkada,KojiMello,Paulo Augusto de ArrudaPrata Jr.,João AntônioGregory,Douglaseng2006-12-15T00:00:00Zoai:scielo:S0004-27492006000500018Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2006-12-15T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
title |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
spellingShingle |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor Paranhos Jr.,Augusto Natriuretic agents Cyclic GMP Aqueous humor Intraocular pressure Ocular physiology/drug effects Glaucoma Natriuretic peptide C-type Circadian rhythm Rabbits |
title_short |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
title_full |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
title_fullStr |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
title_full_unstemmed |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
title_sort |
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor |
author |
Paranhos Jr.,Augusto |
author_facet |
Paranhos Jr.,Augusto Okada,Koji Mello,Paulo Augusto de Arruda Prata Jr.,João Antônio Gregory,Douglas |
author_role |
author |
author2 |
Okada,Koji Mello,Paulo Augusto de Arruda Prata Jr.,João Antônio Gregory,Douglas |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Paranhos Jr.,Augusto Okada,Koji Mello,Paulo Augusto de Arruda Prata Jr.,João Antônio Gregory,Douglas |
dc.subject.por.fl_str_mv |
Natriuretic agents Cyclic GMP Aqueous humor Intraocular pressure Ocular physiology/drug effects Glaucoma Natriuretic peptide C-type Circadian rhythm Rabbits |
topic |
Natriuretic agents Cyclic GMP Aqueous humor Intraocular pressure Ocular physiology/drug effects Glaucoma Natriuretic peptide C-type Circadian rhythm Rabbits |
description |
PURPOSE: To determine whether there is a circadian change of the concentration of C-type natriuretic peptide (CNP) in rabbit aqueous humor. METHODS: Forty-one male white New Zealand rabbits were submitted to a 12 h light and 12 dark lighting schedule; lights on was at 0 h, lights off at 12 h. C-type natriuretic peptide was assayed at 3 light (2 h, 6 h and 10 h) and 3 dark (14,18 and 22 h) times. All groups consisted of four animals but two had more animals to increase the power of tests (6 h, n=12; 22 h, n=13). Dependence between the two eyes was tested by Pearson's correlation. The mean of two eyes was considered for analysis. Differences in concentration in pg/200 ml were evaluated by one-way ANOVA, t test and COSINOR analysis. RESULTS: There were no significant differences between the 6 analyzed groups (one-way ANOVA p=0.157). Pooled into two groups (light and dark), the C-type natriuretic peptide concentration of the light group was lower, 2.626±0.92 pg/200 ml compared with the dark group 3.02±1.16 pg/200 ml but did not reach a significant difference (t test; p=0.23). COSINOR analysis was not statistically significant (R%=7.72 p=0.209). CONCLUSION: These data demonstrate that the concentration of CNP in aqueous humor did not show a statistically significant circadian change in rabbits entrained to a 12 h light: 12 h dark lighting schedule. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000500018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000500018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492006000500018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.69 n.5 2006 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
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1754209023778881536 |