Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy

Detalhes bibliográficos
Autor(a) principal: Lantigua-Dorville,Yrbani
Data de Publicação: 2016
Outros Autores: Saornil,Maria Antonia, García-Alvarez,Ciro, García-Lagarto,Elena
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000100015
Resumo: ABSTRACT A 68-year-old man diagnosed with choroidal melanoma (CM) in the right eye underwent treatment with episcleral brachytherapy (I125) and transpupillary thermotherapy. Ultrasound, computed tomography, and magnetic resonance imaging were performed and revealed ocular recurrence of CM. Treatment with extended enucleation was performed. Macroscopic and microscopic examinations revealed extraocular extension and malignant cells, respectively. Immunohistochemistry demonstrated tumoral Melan-A and HMB-45 expression. No cytogenic abnormalities were detected with fluorescence in situhybridization of tumor cells using probes against chromosomes 3q27 and 8q24. The patient underwent adjuvant external beam radiotherapy for treatment of residual tumor tissue. This case represents the first reported case of recurrent CM with no cytogenetic abnormalities and the absence of metastatic disease, despite a number of the poorest prognostic factors.
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spelling Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapyChoroid neoplasmsMelanomaNeoplasm recurrence, localBrachytherapyCase reportsABSTRACT A 68-year-old man diagnosed with choroidal melanoma (CM) in the right eye underwent treatment with episcleral brachytherapy (I125) and transpupillary thermotherapy. Ultrasound, computed tomography, and magnetic resonance imaging were performed and revealed ocular recurrence of CM. Treatment with extended enucleation was performed. Macroscopic and microscopic examinations revealed extraocular extension and malignant cells, respectively. Immunohistochemistry demonstrated tumoral Melan-A and HMB-45 expression. No cytogenic abnormalities were detected with fluorescence in situhybridization of tumor cells using probes against chromosomes 3q27 and 8q24. The patient underwent adjuvant external beam radiotherapy for treatment of residual tumor tissue. This case represents the first reported case of recurrent CM with no cytogenetic abnormalities and the absence of metastatic disease, despite a number of the poorest prognostic factors.Conselho Brasileiro de Oftalmologia2016-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000100015Arquivos Brasileiros de Oftalmologia v.79 n.1 2016reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20160015info:eu-repo/semantics/openAccessLantigua-Dorville,YrbaniSaornil,Maria AntoniaGarcía-Alvarez,CiroGarcía-Lagarto,Elenaeng2016-01-26T00:00:00Zoai:scielo:S0004-27492016000100015Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2016-01-26T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
title Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
spellingShingle Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
Lantigua-Dorville,Yrbani
Choroid neoplasms
Melanoma
Neoplasm recurrence, local
Brachytherapy
Case reports
title_short Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
title_full Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
title_fullStr Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
title_full_unstemmed Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
title_sort Choroidal melanoma recurrence after episcleral brachytherapy and transpupillary thermotherapy
author Lantigua-Dorville,Yrbani
author_facet Lantigua-Dorville,Yrbani
Saornil,Maria Antonia
García-Alvarez,Ciro
García-Lagarto,Elena
author_role author
author2 Saornil,Maria Antonia
García-Alvarez,Ciro
García-Lagarto,Elena
author2_role author
author
author
dc.contributor.author.fl_str_mv Lantigua-Dorville,Yrbani
Saornil,Maria Antonia
García-Alvarez,Ciro
García-Lagarto,Elena
dc.subject.por.fl_str_mv Choroid neoplasms
Melanoma
Neoplasm recurrence, local
Brachytherapy
Case reports
topic Choroid neoplasms
Melanoma
Neoplasm recurrence, local
Brachytherapy
Case reports
description ABSTRACT A 68-year-old man diagnosed with choroidal melanoma (CM) in the right eye underwent treatment with episcleral brachytherapy (I125) and transpupillary thermotherapy. Ultrasound, computed tomography, and magnetic resonance imaging were performed and revealed ocular recurrence of CM. Treatment with extended enucleation was performed. Macroscopic and microscopic examinations revealed extraocular extension and malignant cells, respectively. Immunohistochemistry demonstrated tumoral Melan-A and HMB-45 expression. No cytogenic abnormalities were detected with fluorescence in situhybridization of tumor cells using probes against chromosomes 3q27 and 8q24. The patient underwent adjuvant external beam radiotherapy for treatment of residual tumor tissue. This case represents the first reported case of recurrent CM with no cytogenetic abnormalities and the absence of metastatic disease, despite a number of the poorest prognostic factors.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000100015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000100015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20160015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.79 n.1 2016
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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