A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny

Detalhes bibliográficos
Autor(a) principal: Aldrovani,Marcela
Data de Publicação: 2017
Outros Autores: Filezio,Marcella Rosa, Laus,José Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000400268
Resumo: ABSTRACT Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i.e., self-renewal or differentiation) can also be influenced by biophysical and mechanical cues related to the supramolecular organization and the liquid crystalline (mesophase) nature of the stromal extracellular matrix. These cues can be sensed by stem cells and transduced into intracellular biochemical and functional responses, a process known as mechanotransduction. The objective of this review is to offer perspectives on the supramolecular microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.
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spelling A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progenyCorneaLimbus corneaeExtracellular matrixLiquid crystalEpithelium, cornealMechanotransduction, cellularStem cell nicheABSTRACT Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i.e., self-renewal or differentiation) can also be influenced by biophysical and mechanical cues related to the supramolecular organization and the liquid crystalline (mesophase) nature of the stromal extracellular matrix. These cues can be sensed by stem cells and transduced into intracellular biochemical and functional responses, a process known as mechanotransduction. The objective of this review is to offer perspectives on the supramolecular microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.Conselho Brasileiro de Oftalmologia2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000400268Arquivos Brasileiros de Oftalmologia v.80 n.4 2017reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20170066info:eu-repo/semantics/openAccessAldrovani,MarcelaFilezio,Marcella RosaLaus,José Luizeng2017-09-18T00:00:00Zoai:scielo:S0004-27492017000400268Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2017-09-18T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
spellingShingle A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
Aldrovani,Marcela
Cornea
Limbus corneae
Extracellular matrix
Liquid crystal
Epithelium, corneal
Mechanotransduction, cellular
Stem cell niche
title_short A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_full A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_fullStr A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_full_unstemmed A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_sort A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
author Aldrovani,Marcela
author_facet Aldrovani,Marcela
Filezio,Marcella Rosa
Laus,José Luiz
author_role author
author2 Filezio,Marcella Rosa
Laus,José Luiz
author2_role author
author
dc.contributor.author.fl_str_mv Aldrovani,Marcela
Filezio,Marcella Rosa
Laus,José Luiz
dc.subject.por.fl_str_mv Cornea
Limbus corneae
Extracellular matrix
Liquid crystal
Epithelium, corneal
Mechanotransduction, cellular
Stem cell niche
topic Cornea
Limbus corneae
Extracellular matrix
Liquid crystal
Epithelium, corneal
Mechanotransduction, cellular
Stem cell niche
description ABSTRACT Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i.e., self-renewal or differentiation) can also be influenced by biophysical and mechanical cues related to the supramolecular organization and the liquid crystalline (mesophase) nature of the stromal extracellular matrix. These cues can be sensed by stem cells and transduced into intracellular biochemical and functional responses, a process known as mechanotransduction. The objective of this review is to offer perspectives on the supramolecular microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000400268
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492017000400268
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20170066
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.80 n.4 2017
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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