Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000550074 |
Resumo: | ABSTRACTPurpose:Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity.Methods:A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively.Results:No significant differences in mean subfoveal, nasal 3000 μm, or temporal 3000 μm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations.Conclusions:Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD. |
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Arquivos brasileiros de oftalmologia (Online) |
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Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel diseaseChoroid/pathologyCrohn's diseaseInflammatory bowel diseaseOptical coherence tomographyUlcerative colitisUveitisABSTRACTPurpose:Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity.Methods:A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively.Results:No significant differences in mean subfoveal, nasal 3000 μm, or temporal 3000 μm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations.Conclusions:Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD.Conselho Brasileiro de Oftalmologia2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000550074Arquivos Brasileiros de Oftalmologia v.78 n.5 2015reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20150074info:eu-repo/semantics/openAccessOnal,Ibrahim KoralYuksel,ErdemBayrakceken,KemalDemir,Muhammed MustafaKaraca,Emine EsraIbis,MehmetAlizadeh,NasserSargin,Zeynep GokHondur,Ahmet MuratArhan,Mehmeteng2015-10-02T00:00:00Zoai:scielo:S0004-27492015000550074Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2015-10-02T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
title |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
spellingShingle |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease Onal,Ibrahim Koral Choroid/pathology Crohn's disease Inflammatory bowel disease Optical coherence tomography Ulcerative colitis Uveitis |
title_short |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
title_full |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
title_fullStr |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
title_full_unstemmed |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
title_sort |
Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease |
author |
Onal,Ibrahim Koral |
author_facet |
Onal,Ibrahim Koral Yuksel,Erdem Bayrakceken,Kemal Demir,Muhammed Mustafa Karaca,Emine Esra Ibis,Mehmet Alizadeh,Nasser Sargin,Zeynep Gok Hondur,Ahmet Murat Arhan,Mehmet |
author_role |
author |
author2 |
Yuksel,Erdem Bayrakceken,Kemal Demir,Muhammed Mustafa Karaca,Emine Esra Ibis,Mehmet Alizadeh,Nasser Sargin,Zeynep Gok Hondur,Ahmet Murat Arhan,Mehmet |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Onal,Ibrahim Koral Yuksel,Erdem Bayrakceken,Kemal Demir,Muhammed Mustafa Karaca,Emine Esra Ibis,Mehmet Alizadeh,Nasser Sargin,Zeynep Gok Hondur,Ahmet Murat Arhan,Mehmet |
dc.subject.por.fl_str_mv |
Choroid/pathology Crohn's disease Inflammatory bowel disease Optical coherence tomography Ulcerative colitis Uveitis |
topic |
Choroid/pathology Crohn's disease Inflammatory bowel disease Optical coherence tomography Ulcerative colitis Uveitis |
description |
ABSTRACTPurpose:Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity.Methods:A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively.Results:No significant differences in mean subfoveal, nasal 3000 μm, or temporal 3000 μm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations.Conclusions:Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000550074 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000550074 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0004-2749.20150074 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.78 n.5 2015 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209028615962624 |