Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000600340 |
Resumo: | ABSTRACT Purpose: To compare the efficacy of intravitreal ranibizumab and bevacizumab treatment for type 1 retinopathy of prematurity (ROP). Methods: 36 eyes of 20 patients with type 1 ROP who received anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections between August 2011 and February 2013 were retrospectively evaluated. Fifteen eyes of 8 patients received 0.25 mg ranibizumab (group 1), and 21 eyes of 12 patients received 0.625 mg bevacizumab (group 2). Eyes were examined by indirect ophthalmoscopy on the first day, third day, first week, and first month and as required after injections. Laser photocoagulation was performed in cases with progression of ROP. Results: The mean gestation time was 26.2 ± 2.7 weeks in group 1 patients and 27.1 ± 2.5 weeks in group 2 patients. No statistical difference in the time of gestation was observed between the two groups. The mean follow-up period was 20 ± 4.5 months. Laser photocoagulation was performed in 6 of 15 eyes from group 1 and 2 of 21 eyes from group 2. No eyes developed retinal detachment during the follow-up period. Conclusion: Ranibizumab and bevacizumab showed an efficacy in the treatment of type 1 ROP. The incidence of disease relapse was higher in eyes which received ranibizumab. Further randomized, controlled clinical trials are required to compare the efficacy of ranibizumab and bevacizumab. |
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Arquivos brasileiros de oftalmologia (Online) |
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Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurityRetinopathy of prematurityVascular endothelial growth factor AAntibodies, monoclonalAngiogenesis inhibitorsIntravitreal injectionsABSTRACT Purpose: To compare the efficacy of intravitreal ranibizumab and bevacizumab treatment for type 1 retinopathy of prematurity (ROP). Methods: 36 eyes of 20 patients with type 1 ROP who received anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections between August 2011 and February 2013 were retrospectively evaluated. Fifteen eyes of 8 patients received 0.25 mg ranibizumab (group 1), and 21 eyes of 12 patients received 0.625 mg bevacizumab (group 2). Eyes were examined by indirect ophthalmoscopy on the first day, third day, first week, and first month and as required after injections. Laser photocoagulation was performed in cases with progression of ROP. Results: The mean gestation time was 26.2 ± 2.7 weeks in group 1 patients and 27.1 ± 2.5 weeks in group 2 patients. No statistical difference in the time of gestation was observed between the two groups. The mean follow-up period was 20 ± 4.5 months. Laser photocoagulation was performed in 6 of 15 eyes from group 1 and 2 of 21 eyes from group 2. No eyes developed retinal detachment during the follow-up period. Conclusion: Ranibizumab and bevacizumab showed an efficacy in the treatment of type 1 ROP. The incidence of disease relapse was higher in eyes which received ranibizumab. Further randomized, controlled clinical trials are required to compare the efficacy of ranibizumab and bevacizumab.Conselho Brasileiro de Oftalmologia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000600340Arquivos Brasileiros de Oftalmologia v.78 n.6 2015reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20150090info:eu-repo/semantics/openAccessErol,Muhammet KazimCoban,Deniz TurgutSari,Esin SogutluBilgin,Ahmet BurakDogan,BernaOzdemir,OzdemirTunay,Zuhal Ozeneng2015-12-09T00:00:00Zoai:scielo:S0004-27492015000600340Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2015-12-09T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
title |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
spellingShingle |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity Erol,Muhammet Kazim Retinopathy of prematurity Vascular endothelial growth factor A Antibodies, monoclonal Angiogenesis inhibitors Intravitreal injections |
title_short |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
title_full |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
title_fullStr |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
title_full_unstemmed |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
title_sort |
Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity |
author |
Erol,Muhammet Kazim |
author_facet |
Erol,Muhammet Kazim Coban,Deniz Turgut Sari,Esin Sogutlu Bilgin,Ahmet Burak Dogan,Berna Ozdemir,Ozdemir Tunay,Zuhal Ozen |
author_role |
author |
author2 |
Coban,Deniz Turgut Sari,Esin Sogutlu Bilgin,Ahmet Burak Dogan,Berna Ozdemir,Ozdemir Tunay,Zuhal Ozen |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Erol,Muhammet Kazim Coban,Deniz Turgut Sari,Esin Sogutlu Bilgin,Ahmet Burak Dogan,Berna Ozdemir,Ozdemir Tunay,Zuhal Ozen |
dc.subject.por.fl_str_mv |
Retinopathy of prematurity Vascular endothelial growth factor A Antibodies, monoclonal Angiogenesis inhibitors Intravitreal injections |
topic |
Retinopathy of prematurity Vascular endothelial growth factor A Antibodies, monoclonal Angiogenesis inhibitors Intravitreal injections |
description |
ABSTRACT Purpose: To compare the efficacy of intravitreal ranibizumab and bevacizumab treatment for type 1 retinopathy of prematurity (ROP). Methods: 36 eyes of 20 patients with type 1 ROP who received anti-vascular endothelial growth factor (anti-VEGF) intravitreal injections between August 2011 and February 2013 were retrospectively evaluated. Fifteen eyes of 8 patients received 0.25 mg ranibizumab (group 1), and 21 eyes of 12 patients received 0.625 mg bevacizumab (group 2). Eyes were examined by indirect ophthalmoscopy on the first day, third day, first week, and first month and as required after injections. Laser photocoagulation was performed in cases with progression of ROP. Results: The mean gestation time was 26.2 ± 2.7 weeks in group 1 patients and 27.1 ± 2.5 weeks in group 2 patients. No statistical difference in the time of gestation was observed between the two groups. The mean follow-up period was 20 ± 4.5 months. Laser photocoagulation was performed in 6 of 15 eyes from group 1 and 2 of 21 eyes from group 2. No eyes developed retinal detachment during the follow-up period. Conclusion: Ranibizumab and bevacizumab showed an efficacy in the treatment of type 1 ROP. The incidence of disease relapse was higher in eyes which received ranibizumab. Further randomized, controlled clinical trials are required to compare the efficacy of ranibizumab and bevacizumab. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000600340 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000600340 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0004-2749.20150090 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.78 n.6 2015 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
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1754209028642177024 |