Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy

Detalhes bibliográficos
Autor(a) principal: Ventura,Bruna Vieira
Data de Publicação: 2012
Outros Autores: Miller,Marilyn Tiller, Danda,Diana, Carta,Arturo, Brandt,Carlos Teixeira, Ventura,Liana Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300011
Resumo: PURPOSE: To compare the profiles and clinical findings of a series of patients with Möbius sequence from Brazil with a series from Italy. METHODS: This is a multicenter study, which includes 46 Möbius sequence patients from Brazil and 20 from Italy. Socio-demographic, gestational, and neonatal profile characteristics were collected from interviews with the guardians of the Möbius sequence patients and compared. The Möbius sequence patients were submitted to an ophthalmologic examination and systemic malformations were also evaluated. RESULTS: Misoprostol was used in the first trimester of pregnancy by 26 (56.5%) of the mothers of the Möbius sequence patients in the Brazilian series and was not used by any of the Italian mothers. The mean age of the Brazilian Möbius sequence patients was 89.95 ± 7.79 months and the mean age of the Italian patients was 102.6 ± 22.94 months (P=0.6105; Mann-Whitney test). Brazilian mothers had a significantly lower education level (P=0.0002; Fisher's exact test) and Italian mothers had significantly more stable relationships (p=0.0002; Fisher's exact test). The frequency of ocular and systemic abnormalities was similar in both series. CONCLUSION: Adverse events during pregnancy varied between both groups. A history of misoprostol use during early pregnancy was present only in Brazilian mothers, who had lower levels of education and less frequent stable marital statuses. Clinical findings were similar between both groups of patients.
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spelling Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and ItalyMöbius syndromeMisoprostol/adverse effectsOcular motility disorderEducationBrazilItalyPURPOSE: To compare the profiles and clinical findings of a series of patients with Möbius sequence from Brazil with a series from Italy. METHODS: This is a multicenter study, which includes 46 Möbius sequence patients from Brazil and 20 from Italy. Socio-demographic, gestational, and neonatal profile characteristics were collected from interviews with the guardians of the Möbius sequence patients and compared. The Möbius sequence patients were submitted to an ophthalmologic examination and systemic malformations were also evaluated. RESULTS: Misoprostol was used in the first trimester of pregnancy by 26 (56.5%) of the mothers of the Möbius sequence patients in the Brazilian series and was not used by any of the Italian mothers. The mean age of the Brazilian Möbius sequence patients was 89.95 ± 7.79 months and the mean age of the Italian patients was 102.6 ± 22.94 months (P=0.6105; Mann-Whitney test). Brazilian mothers had a significantly lower education level (P=0.0002; Fisher's exact test) and Italian mothers had significantly more stable relationships (p=0.0002; Fisher's exact test). The frequency of ocular and systemic abnormalities was similar in both series. CONCLUSION: Adverse events during pregnancy varied between both groups. A history of misoprostol use during early pregnancy was present only in Brazilian mothers, who had lower levels of education and less frequent stable marital statuses. Clinical findings were similar between both groups of patients.Conselho Brasileiro de Oftalmologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300011Arquivos Brasileiros de Oftalmologia v.75 n.3 2012reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492012000300011info:eu-repo/semantics/openAccessVentura,Bruna VieiraMiller,Marilyn TillerDanda,DianaCarta,ArturoBrandt,Carlos TeixeiraVentura,Liana Oliveiraeng2012-08-02T00:00:00Zoai:scielo:S0004-27492012000300011Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2012-08-02T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
title Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
spellingShingle Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
Ventura,Bruna Vieira
Möbius syndrome
Misoprostol/adverse effects
Ocular motility disorder
Education
Brazil
Italy
title_short Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
title_full Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
title_fullStr Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
title_full_unstemmed Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
title_sort Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy
author Ventura,Bruna Vieira
author_facet Ventura,Bruna Vieira
Miller,Marilyn Tiller
Danda,Diana
Carta,Arturo
Brandt,Carlos Teixeira
Ventura,Liana Oliveira
author_role author
author2 Miller,Marilyn Tiller
Danda,Diana
Carta,Arturo
Brandt,Carlos Teixeira
Ventura,Liana Oliveira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ventura,Bruna Vieira
Miller,Marilyn Tiller
Danda,Diana
Carta,Arturo
Brandt,Carlos Teixeira
Ventura,Liana Oliveira
dc.subject.por.fl_str_mv Möbius syndrome
Misoprostol/adverse effects
Ocular motility disorder
Education
Brazil
Italy
topic Möbius syndrome
Misoprostol/adverse effects
Ocular motility disorder
Education
Brazil
Italy
description PURPOSE: To compare the profiles and clinical findings of a series of patients with Möbius sequence from Brazil with a series from Italy. METHODS: This is a multicenter study, which includes 46 Möbius sequence patients from Brazil and 20 from Italy. Socio-demographic, gestational, and neonatal profile characteristics were collected from interviews with the guardians of the Möbius sequence patients and compared. The Möbius sequence patients were submitted to an ophthalmologic examination and systemic malformations were also evaluated. RESULTS: Misoprostol was used in the first trimester of pregnancy by 26 (56.5%) of the mothers of the Möbius sequence patients in the Brazilian series and was not used by any of the Italian mothers. The mean age of the Brazilian Möbius sequence patients was 89.95 ± 7.79 months and the mean age of the Italian patients was 102.6 ± 22.94 months (P=0.6105; Mann-Whitney test). Brazilian mothers had a significantly lower education level (P=0.0002; Fisher's exact test) and Italian mothers had significantly more stable relationships (p=0.0002; Fisher's exact test). The frequency of ocular and systemic abnormalities was similar in both series. CONCLUSION: Adverse events during pregnancy varied between both groups. A history of misoprostol use during early pregnancy was present only in Brazilian mothers, who had lower levels of education and less frequent stable marital statuses. Clinical findings were similar between both groups of patients.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492012000300011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.75 n.3 2012
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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