Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

• Autor(a) principal: Lira,Rodrigo Pessoa Cavalcanti
• Data de Publicação: 2007
• Outros Autores: Moraes,Luiz Felipe Lynch de, Oliveira Júnior,Mauro de, Melo,Antônio Luiz Barbosa de, Vasconcelos,Mirelle Souza Leão
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos brasileiros de oftalmologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492007000100019
• topic: Nausea/prevention & control; Metoclopramide/therapeutic use; Fluorescein angiography; Drug hypersensitivity; Randomized controlled trial

PURPOSES: To determine the efficacy of bromopride in the prophylaxis of nausea during fluorescein angiography, when compared with a placebo. METHODS: The study was a double-masked random clinical trial, between December of 2004 and April of 2005. Examinations were performed with 20% intravenous fluorescein sodium in a single dose of 2.5 ml. The patients were divided into two groups: group 1, patients who received a 2 ml intravenous dose of 5 mg/ml bromopride and group 2, patients who received a 2 ml intravenous dose of 0.9% sodium chloride (placebo), both 20 minutes before the dye injection. Cases of nausea were observed during and after the examination. RESULTS: 352 patients were enrolled, 176 in each group. Cases of nausea were observed in 12 (6.8%) patients of the bromopride group and in 11 (6.3%) patients of the placebo group (p<0.829 - relative risk=1.05). CONCLUSION: Bromopride did not prevent the occurrence of nausea in fluorescein angiography, when compared with a placebo.