Interferon-associated retinopathy in a patient with metastatic melanoma

Detalhes bibliográficos
Autor(a) principal: Borrego-Sanz,Lara
Data de Publicação: 2014
Outros Autores: Sáenz-Francés,Federico, Fernández-Tresguerres,M. Fernanda, Jiménez-Santos,Maria, Donate-López,Juan
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000500285
Resumo: We present the unusual case of a 35 year-old woman with stage IV melanoma and widespread metastases, who was undergoing treatment with interferon alpha-2b and who presented with interferon-associated retinopathy. The patient, who had been taking interferon treatment for three months, complained of a sudden loss of visual acuity in the left eye. An ocular examination revealed multiple cotton wool spots along the retina and macular involvement. Interferon treatment was suspended. Although rare, retinopathy represents a potentially serious adverse effect of interferon treatment. Although normally patients are asymptomatic, complications derived of its use may arise, which can lead to significant visual impairment. We therefore suggest that before initiating treatment with this drug, patients should be informed of its potential ocular risks, and that regular eye examinations are conducted along with the treatment.
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spelling Interferon-associated retinopathy in a patient with metastatic melanomaInterferon alfa/therapeutic useInterferon alfa/adverse effectsMelanoma/secondaryRetinal diseases/chemically inducedCase reportsWe present the unusual case of a 35 year-old woman with stage IV melanoma and widespread metastases, who was undergoing treatment with interferon alpha-2b and who presented with interferon-associated retinopathy. The patient, who had been taking interferon treatment for three months, complained of a sudden loss of visual acuity in the left eye. An ocular examination revealed multiple cotton wool spots along the retina and macular involvement. Interferon treatment was suspended. Although rare, retinopathy represents a potentially serious adverse effect of interferon treatment. Although normally patients are asymptomatic, complications derived of its use may arise, which can lead to significant visual impairment. We therefore suggest that before initiating treatment with this drug, patients should be informed of its potential ocular risks, and that regular eye examinations are conducted along with the treatment.Conselho Brasileiro de Oftalmologia2014-10-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000500285Arquivos Brasileiros de Oftalmologia v.77 n.5 2014reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20140080info:eu-repo/semantics/openAccessBorrego-Sanz,LaraSáenz-Francés,FedericoFernández-Tresguerres,M. FernandaJiménez-Santos,MariaDonate-López,Juaneng2015-04-10T00:00:00Zoai:scielo:S0004-27492014000500285Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2015-04-10T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Interferon-associated retinopathy in a patient with metastatic melanoma
title Interferon-associated retinopathy in a patient with metastatic melanoma
spellingShingle Interferon-associated retinopathy in a patient with metastatic melanoma
Borrego-Sanz,Lara
Interferon alfa/therapeutic use
Interferon alfa/adverse effects
Melanoma/secondary
Retinal diseases/chemically induced
Case reports
title_short Interferon-associated retinopathy in a patient with metastatic melanoma
title_full Interferon-associated retinopathy in a patient with metastatic melanoma
title_fullStr Interferon-associated retinopathy in a patient with metastatic melanoma
title_full_unstemmed Interferon-associated retinopathy in a patient with metastatic melanoma
title_sort Interferon-associated retinopathy in a patient with metastatic melanoma
author Borrego-Sanz,Lara
author_facet Borrego-Sanz,Lara
Sáenz-Francés,Federico
Fernández-Tresguerres,M. Fernanda
Jiménez-Santos,Maria
Donate-López,Juan
author_role author
author2 Sáenz-Francés,Federico
Fernández-Tresguerres,M. Fernanda
Jiménez-Santos,Maria
Donate-López,Juan
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Borrego-Sanz,Lara
Sáenz-Francés,Federico
Fernández-Tresguerres,M. Fernanda
Jiménez-Santos,Maria
Donate-López,Juan
dc.subject.por.fl_str_mv Interferon alfa/therapeutic use
Interferon alfa/adverse effects
Melanoma/secondary
Retinal diseases/chemically induced
Case reports
topic Interferon alfa/therapeutic use
Interferon alfa/adverse effects
Melanoma/secondary
Retinal diseases/chemically induced
Case reports
description We present the unusual case of a 35 year-old woman with stage IV melanoma and widespread metastases, who was undergoing treatment with interferon alpha-2b and who presented with interferon-associated retinopathy. The patient, who had been taking interferon treatment for three months, complained of a sudden loss of visual acuity in the left eye. An ocular examination revealed multiple cotton wool spots along the retina and macular involvement. Interferon treatment was suspended. Although rare, retinopathy represents a potentially serious adverse effect of interferon treatment. Although normally patients are asymptomatic, complications derived of its use may arise, which can lead to significant visual impairment. We therefore suggest that before initiating treatment with this drug, patients should be informed of its potential ocular risks, and that regular eye examinations are conducted along with the treatment.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000500285
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492014000500285
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20140080
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.77 n.5 2014
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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