Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492005000400021 |
Resumo: | To report a case of ocular copper deposition in both eyes at the level of Descemet's membrane associated with a monoclonal gammopathy of undetermined significance (MGUS). A 49-year-old white woman had golden-brown metallic dust-like deposits on Descemet's membrane of both eyes. A systemic examination revealed an elevated serum copper, normal serum ceruloplasmin and a normal level of total protein. Serum protein electrophoresis demonstrated a single peak (M-spike) in the gamma region (M-protein in serum = 11 g/l). Flow cytometric analysis of the marrow aspirate identified a monoclonal plasma cell population that represents approximately 2% of the total marrow cells consistent with the diagnosis of monoclonal gammopathy of undetermined significance. Copper deposits at the level of Descemet's membrane may be a finding in a patient with monoclonal gammopathy of undetermined significance. |
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Arquivos brasileiros de oftalmologia (Online) |
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Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case reportCopper/analysisBlood protein electrophoresisDescemet's membraneGama-globulins/diagnosisParaproteinemias/diagnosisTo report a case of ocular copper deposition in both eyes at the level of Descemet's membrane associated with a monoclonal gammopathy of undetermined significance (MGUS). A 49-year-old white woman had golden-brown metallic dust-like deposits on Descemet's membrane of both eyes. A systemic examination revealed an elevated serum copper, normal serum ceruloplasmin and a normal level of total protein. Serum protein electrophoresis demonstrated a single peak (M-spike) in the gamma region (M-protein in serum = 11 g/l). Flow cytometric analysis of the marrow aspirate identified a monoclonal plasma cell population that represents approximately 2% of the total marrow cells consistent with the diagnosis of monoclonal gammopathy of undetermined significance. Copper deposits at the level of Descemet's membrane may be a finding in a patient with monoclonal gammopathy of undetermined significance.Conselho Brasileiro de Oftalmologia2005-08-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492005000400021Arquivos Brasileiros de Oftalmologia v.68 n.4 2005reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492005000400021info:eu-repo/semantics/openAccessTzelikis,Patrick F.Laibson,Peter R.Ribeiro,Marco P.Rapuano,Christopher J.Hammersmith,Kristin M.Cohen,Elisabeth J.eng2005-11-22T00:00:00Zoai:scielo:S0004-27492005000400021Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2005-11-22T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
title |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
spellingShingle |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report Tzelikis,Patrick F. Copper/analysis Blood protein electrophoresis Descemet's membrane Gama-globulins/diagnosis Paraproteinemias/diagnosis |
title_short |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
title_full |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
title_fullStr |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
title_full_unstemmed |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
title_sort |
Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report |
author |
Tzelikis,Patrick F. |
author_facet |
Tzelikis,Patrick F. Laibson,Peter R. Ribeiro,Marco P. Rapuano,Christopher J. Hammersmith,Kristin M. Cohen,Elisabeth J. |
author_role |
author |
author2 |
Laibson,Peter R. Ribeiro,Marco P. Rapuano,Christopher J. Hammersmith,Kristin M. Cohen,Elisabeth J. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Tzelikis,Patrick F. Laibson,Peter R. Ribeiro,Marco P. Rapuano,Christopher J. Hammersmith,Kristin M. Cohen,Elisabeth J. |
dc.subject.por.fl_str_mv |
Copper/analysis Blood protein electrophoresis Descemet's membrane Gama-globulins/diagnosis Paraproteinemias/diagnosis |
topic |
Copper/analysis Blood protein electrophoresis Descemet's membrane Gama-globulins/diagnosis Paraproteinemias/diagnosis |
description |
To report a case of ocular copper deposition in both eyes at the level of Descemet's membrane associated with a monoclonal gammopathy of undetermined significance (MGUS). A 49-year-old white woman had golden-brown metallic dust-like deposits on Descemet's membrane of both eyes. A systemic examination revealed an elevated serum copper, normal serum ceruloplasmin and a normal level of total protein. Serum protein electrophoresis demonstrated a single peak (M-spike) in the gamma region (M-protein in serum = 11 g/l). Flow cytometric analysis of the marrow aspirate identified a monoclonal plasma cell population that represents approximately 2% of the total marrow cells consistent with the diagnosis of monoclonal gammopathy of undetermined significance. Copper deposits at the level of Descemet's membrane may be a finding in a patient with monoclonal gammopathy of undetermined significance. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492005000400021 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492005000400021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492005000400021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.68 n.4 2005 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
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1754209022969380864 |