Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report

• Autor(a) principal: Tzelikis,Patrick F.
• Data de Publicação: 2005
• Outros Autores: Laibson,Peter R., Ribeiro,Marco P., Rapuano,Christopher J., Hammersmith,Kristin M., Cohen,Elisabeth J.
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Arquivos brasileiros de oftalmologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492005000400021
• topic: Copper/analysis; Blood protein electrophoresis; Descemet's membrane; Gama-globulins/diagnosis; Paraproteinemias/diagnosis

To report a case of ocular copper deposition in both eyes at the level of Descemet's membrane associated with a monoclonal gammopathy of undetermined significance (MGUS). A 49-year-old white woman had golden-brown metallic dust-like deposits on Descemet's membrane of both eyes. A systemic examination revealed an elevated serum copper, normal serum ceruloplasmin and a normal level of total protein. Serum protein electrophoresis demonstrated a single peak (M-spike) in the gamma region (M-protein in serum = 11 g/l). Flow cytometric analysis of the marrow aspirate identified a monoclonal plasma cell population that represents approximately 2% of the total marrow cells consistent with the diagnosis of monoclonal gammopathy of undetermined significance. Copper deposits at the level of Descemet's membrane may be a finding in a patient with monoclonal gammopathy of undetermined significance.