Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement

Detalhes bibliográficos
Autor(a) principal: Karaca,Emine Esra
Data de Publicação: 2020
Outros Autores: Kemer,Özlem Evren, Özek,Dilay, Berker,Dilek, Imga,Narin Nasiroglu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000400312
Resumo: ABSTRACT Purpose: To analyze the clinical outcomes of the ocular surface in patients with vitamin D deficiency after oral replacement. Methods: A total of 40 patients with vitamin D deficiency were enrolled in the study. The patients received 50,000 units of oral vitamin D weekly over a period of 8 weeks. After 8 weeks, 1,500-2,000 units/d were administered for 24 weeks. Eyelid margin score, meibomian gland expressibility score, Oxford grading, Schirmer I test, tear breakup time, tear osmolarity, and the Ocular Surface Disease Index score were evaluated at baseline, and at 8, 12, and 24 weeks. Results: The meibomian gland expressibility score, Schirmer I, tear breakup time, tear osmolarity, and Ocular Surface Disease Index score showed improvement 8 weeks after vitamin D supplementation (p<0.05). Compared with the pretreatment values, the eyelid margin score and Oxford grading were decreased at week 12 (p<0.05). Conclusion: Vitamin D replacement appears to improve ocular surface in individuals with vitamin D deficiency.
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spelling Clinical outcomes of ocular surface in patients treated with vitamin D oral replacementDry eye syndromeVitamin D deficiencyDietary supplementsABSTRACT Purpose: To analyze the clinical outcomes of the ocular surface in patients with vitamin D deficiency after oral replacement. Methods: A total of 40 patients with vitamin D deficiency were enrolled in the study. The patients received 50,000 units of oral vitamin D weekly over a period of 8 weeks. After 8 weeks, 1,500-2,000 units/d were administered for 24 weeks. Eyelid margin score, meibomian gland expressibility score, Oxford grading, Schirmer I test, tear breakup time, tear osmolarity, and the Ocular Surface Disease Index score were evaluated at baseline, and at 8, 12, and 24 weeks. Results: The meibomian gland expressibility score, Schirmer I, tear breakup time, tear osmolarity, and Ocular Surface Disease Index score showed improvement 8 weeks after vitamin D supplementation (p<0.05). Compared with the pretreatment values, the eyelid margin score and Oxford grading were decreased at week 12 (p<0.05). Conclusion: Vitamin D replacement appears to improve ocular surface in individuals with vitamin D deficiency.Conselho Brasileiro de Oftalmologia2020-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000400312Arquivos Brasileiros de Oftalmologia v.83 n.4 2020reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20200043info:eu-repo/semantics/openAccessKaraca,Emine EsraKemer,Özlem EvrenÖzek,DilayBerker,DilekImga,Narin Nasiroglueng2020-07-27T00:00:00Zoai:scielo:S0004-27492020000400312Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2020-07-27T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
title Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
spellingShingle Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
Karaca,Emine Esra
Dry eye syndrome
Vitamin D deficiency
Dietary supplements
title_short Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
title_full Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
title_fullStr Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
title_full_unstemmed Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
title_sort Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement
author Karaca,Emine Esra
author_facet Karaca,Emine Esra
Kemer,Özlem Evren
Özek,Dilay
Berker,Dilek
Imga,Narin Nasiroglu
author_role author
author2 Kemer,Özlem Evren
Özek,Dilay
Berker,Dilek
Imga,Narin Nasiroglu
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Karaca,Emine Esra
Kemer,Özlem Evren
Özek,Dilay
Berker,Dilek
Imga,Narin Nasiroglu
dc.subject.por.fl_str_mv Dry eye syndrome
Vitamin D deficiency
Dietary supplements
topic Dry eye syndrome
Vitamin D deficiency
Dietary supplements
description ABSTRACT Purpose: To analyze the clinical outcomes of the ocular surface in patients with vitamin D deficiency after oral replacement. Methods: A total of 40 patients with vitamin D deficiency were enrolled in the study. The patients received 50,000 units of oral vitamin D weekly over a period of 8 weeks. After 8 weeks, 1,500-2,000 units/d were administered for 24 weeks. Eyelid margin score, meibomian gland expressibility score, Oxford grading, Schirmer I test, tear breakup time, tear osmolarity, and the Ocular Surface Disease Index score were evaluated at baseline, and at 8, 12, and 24 weeks. Results: The meibomian gland expressibility score, Schirmer I, tear breakup time, tear osmolarity, and Ocular Surface Disease Index score showed improvement 8 weeks after vitamin D supplementation (p<0.05). Compared with the pretreatment values, the eyelid margin score and Oxford grading were decreased at week 12 (p<0.05). Conclusion: Vitamin D replacement appears to improve ocular surface in individuals with vitamin D deficiency.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000400312
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000400312
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20200043
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.83 n.4 2020
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
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reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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