Hematological alterations during experimental canine infection by Trypanosoma cruzi

• Autor(a) principal: Guedes,Paulo Marcos Matta
• Data de Publicação: 2012
• Outros Autores: Veloso,Vanja Maria, Mineo,Tiago Wilson Patriarca, Santiago-Silva,Juliana, Crepalde,Geovan, Caldas,Ivo Santana, Nascimento,Manuela Sales Lima, Lana,Marta, Chiari,Egler, Galvão,Lúcia Maria da Cunha, Bahia,Maria Terezinha
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000200015
• topic: Trypanosoma cruzi; Beagle dogs; parasitemia; lymphocytosis; anemia; leukocytosis

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.