Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Parasitologia Veterinária (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612016000200244 |
Resumo: | Abstract Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis. Eleven dogs presented inflammatory liver lesions, with predominance of mild multifocal mononuclear periportal hepatitis. No association between the presence of parasites and abnormalities in screening tests was observed by Spearman’s rank correlation coefficient. The clinical progression in leishmaniasis is associated with the occurrence of hemorrhagic diathesis, which depends not only on the presence of the parasite but also the inflammatory process, compromised immunological response, hepatic and renal failure in symptomatic dogs. |
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Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasiCoagulationleishmaniasisliverqPCRAbstract Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis. Eleven dogs presented inflammatory liver lesions, with predominance of mild multifocal mononuclear periportal hepatitis. No association between the presence of parasites and abnormalities in screening tests was observed by Spearman’s rank correlation coefficient. The clinical progression in leishmaniasis is associated with the occurrence of hemorrhagic diathesis, which depends not only on the presence of the parasite but also the inflammatory process, compromised immunological response, hepatic and renal failure in symptomatic dogs.Colégio Brasileiro de Parasitologia Veterinária2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612016000200244Revista Brasileira de Parasitologia Veterinária v.25 n.2 2016reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/S1984-29612016036info:eu-repo/semantics/openAccessTorres,Mariana de MedeirosAlmeida,Arleana do Bom Parto Ferreira dePaula,Daphine Ariadne Jesus deMendonça,Adriane JorgeNakazato,LucianoPescador,Caroline ArgentaSousa,Valéria Régia Francoeng2016-06-15T00:00:00Zoai:scielo:S1984-29612016000200244Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2016-06-15T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false |
dc.title.none.fl_str_mv |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
title |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
spellingShingle |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi Torres,Mariana de Medeiros Coagulation leishmaniasis liver qPCR |
title_short |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
title_full |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
title_fullStr |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
title_full_unstemmed |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
title_sort |
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi |
author |
Torres,Mariana de Medeiros |
author_facet |
Torres,Mariana de Medeiros Almeida,Arleana do Bom Parto Ferreira de Paula,Daphine Ariadne Jesus de Mendonça,Adriane Jorge Nakazato,Luciano Pescador,Caroline Argenta Sousa,Valéria Régia Franco |
author_role |
author |
author2 |
Almeida,Arleana do Bom Parto Ferreira de Paula,Daphine Ariadne Jesus de Mendonça,Adriane Jorge Nakazato,Luciano Pescador,Caroline Argenta Sousa,Valéria Régia Franco |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Torres,Mariana de Medeiros Almeida,Arleana do Bom Parto Ferreira de Paula,Daphine Ariadne Jesus de Mendonça,Adriane Jorge Nakazato,Luciano Pescador,Caroline Argenta Sousa,Valéria Régia Franco |
dc.subject.por.fl_str_mv |
Coagulation leishmaniasis liver qPCR |
topic |
Coagulation leishmaniasis liver qPCR |
description |
Abstract Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis. Eleven dogs presented inflammatory liver lesions, with predominance of mild multifocal mononuclear periportal hepatitis. No association between the presence of parasites and abnormalities in screening tests was observed by Spearman’s rank correlation coefficient. The clinical progression in leishmaniasis is associated with the occurrence of hemorrhagic diathesis, which depends not only on the presence of the parasite but also the inflammatory process, compromised immunological response, hepatic and renal failure in symptomatic dogs. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612016000200244 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612016000200244 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1984-29612016036 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
dc.source.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária v.25 n.2 2016 reponame:Revista Brasileira de Parasitologia Veterinária (Online) instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV) instacron:CBPV |
instname_str |
Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
instacron_str |
CBPV |
institution |
CBPV |
reponame_str |
Revista Brasileira de Parasitologia Veterinária (Online) |
collection |
Revista Brasileira de Parasitologia Veterinária (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
repository.mail.fl_str_mv |
||zacariascbpv@fcav.unesp.br |
_version_ |
1754208916256849920 |