Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum

Detalhes bibliográficos
Autor(a) principal: Pereira,Luiz Miguel
Data de Publicação: 2021
Outros Autores: de Luca,Gabriela, Abichabki,Nathália de Lima Martins, Brochi,Jade Cabestre Venancio, Baroni,Luciana, Abreu-Filho,Péricles Gama, Yatsuda,Ana Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612021000100312
Resumo: Abstract Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting in significant economic losses. There is no commercial treatment for neosporosis, and drug repositioning is a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine and tetracycline on N. caninum proliferation. The IC50 concentrations in N. caninum were compared to the current information based on previous studies for Plasmodium and Toxoplasma gondii, correlating to the described mechanisms of action of each tested drug. The inhibitory patterns indicate similarities and differences among N. caninum, Plasmodium and T. gondii. For example, atovaquone demonstrates high antiparasitic activity in all the analyzed models, while chloroquine does not inhibit N. caninum. On the other hand, tetracycline is effective against Plasmodium and N. caninum, despite its low activity in T. gondii models. The repurposing of antimalarial drugs in N. caninum is a fast and inexpensive way to develop novel formulations using well-established compounds.
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spelling Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninumNeospora caninumatovaquonechloroquinequinineprimaquinetetracyclineAbstract Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting in significant economic losses. There is no commercial treatment for neosporosis, and drug repositioning is a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine and tetracycline on N. caninum proliferation. The IC50 concentrations in N. caninum were compared to the current information based on previous studies for Plasmodium and Toxoplasma gondii, correlating to the described mechanisms of action of each tested drug. The inhibitory patterns indicate similarities and differences among N. caninum, Plasmodium and T. gondii. For example, atovaquone demonstrates high antiparasitic activity in all the analyzed models, while chloroquine does not inhibit N. caninum. On the other hand, tetracycline is effective against Plasmodium and N. caninum, despite its low activity in T. gondii models. The repurposing of antimalarial drugs in N. caninum is a fast and inexpensive way to develop novel formulations using well-established compounds.Colégio Brasileiro de Parasitologia Veterinária2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612021000100312Revista Brasileira de Parasitologia Veterinária v.30 n.1 2021reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/s1984-29612021006info:eu-repo/semantics/openAccessPereira,Luiz Miguelde Luca,GabrielaAbichabki,Nathália de Lima MartinsBrochi,Jade Cabestre VenancioBaroni,LucianaAbreu-Filho,Péricles GamaYatsuda,Ana Patríciaeng2021-03-23T00:00:00Zoai:scielo:S1984-29612021000100312Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2021-03-23T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false
dc.title.none.fl_str_mv Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
title Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
spellingShingle Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
Pereira,Luiz Miguel
Neospora caninum
atovaquone
chloroquine
quinine
primaquine
tetracycline
title_short Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
title_full Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
title_fullStr Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
title_full_unstemmed Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
title_sort Atovaquone, chloroquine, primaquine, quinine and tetracycline: antiproliferative effects of relevant antimalarials on Neospora caninum
author Pereira,Luiz Miguel
author_facet Pereira,Luiz Miguel
de Luca,Gabriela
Abichabki,Nathália de Lima Martins
Brochi,Jade Cabestre Venancio
Baroni,Luciana
Abreu-Filho,Péricles Gama
Yatsuda,Ana Patrícia
author_role author
author2 de Luca,Gabriela
Abichabki,Nathália de Lima Martins
Brochi,Jade Cabestre Venancio
Baroni,Luciana
Abreu-Filho,Péricles Gama
Yatsuda,Ana Patrícia
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira,Luiz Miguel
de Luca,Gabriela
Abichabki,Nathália de Lima Martins
Brochi,Jade Cabestre Venancio
Baroni,Luciana
Abreu-Filho,Péricles Gama
Yatsuda,Ana Patrícia
dc.subject.por.fl_str_mv Neospora caninum
atovaquone
chloroquine
quinine
primaquine
tetracycline
topic Neospora caninum
atovaquone
chloroquine
quinine
primaquine
tetracycline
description Abstract Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting in significant economic losses. There is no commercial treatment for neosporosis, and drug repositioning is a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine and tetracycline on N. caninum proliferation. The IC50 concentrations in N. caninum were compared to the current information based on previous studies for Plasmodium and Toxoplasma gondii, correlating to the described mechanisms of action of each tested drug. The inhibitory patterns indicate similarities and differences among N. caninum, Plasmodium and T. gondii. For example, atovaquone demonstrates high antiparasitic activity in all the analyzed models, while chloroquine does not inhibit N. caninum. On the other hand, tetracycline is effective against Plasmodium and N. caninum, despite its low activity in T. gondii models. The repurposing of antimalarial drugs in N. caninum is a fast and inexpensive way to develop novel formulations using well-established compounds.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612021000100312
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/s1984-29612021006
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dc.publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
dc.source.none.fl_str_mv Revista Brasileira de Parasitologia Veterinária v.30 n.1 2021
reponame:Revista Brasileira de Parasitologia Veterinária (Online)
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instname_str Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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