Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Radiologia Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842021000200077 |
Resumo: | Abstract Objective: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). Materials and Methods: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2-3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2-7 days after contrast administration. Results: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. We found no association between AKI and the risk factors evaluated. Conclusion: We identified no criteria for contrast-induced nephropathy after CT; nor did we find AKI to be associated with the classical risk factors. |
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Radiologia Brasileira (Online) |
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Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomographyAcute kidney injuryTomography, X-ray computedContrast media/adverse effectsContrast media/administration & dosageIodine radioisotopesCreatinine/bloodAbstract Objective: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). Materials and Methods: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2-3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2-7 days after contrast administration. Results: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. We found no association between AKI and the risk factors evaluated. Conclusion: We identified no criteria for contrast-induced nephropathy after CT; nor did we find AKI to be associated with the classical risk factors.Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842021000200077Radiologia Brasileira v.54 n.2 2021reponame:Radiologia Brasileira (Online)instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)instacron:CBR10.1590/0100-3984.2020.0018info:eu-repo/semantics/openAccessCoser,Thyago A.Leitão,Juliana S. V.Beltrame,Betina M.Selistre,Luciano S.Tasso,Leandroeng2021-03-24T00:00:00Zoai:scielo:S0100-39842021000200077Revistahttps://www.scielo.br/j/rb/https://old.scielo.br/oai/scielo-oai.phpradiologiabrasileira@cbr.org.br1678-70990100-3984opendoar:2021-03-24T00:00Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)false |
dc.title.none.fl_str_mv |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
title |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
spellingShingle |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography Coser,Thyago A. Acute kidney injury Tomography, X-ray computed Contrast media/adverse effects Contrast media/administration & dosage Iodine radioisotopes Creatinine/blood |
title_short |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
title_full |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
title_fullStr |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
title_full_unstemmed |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
title_sort |
Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography |
author |
Coser,Thyago A. |
author_facet |
Coser,Thyago A. Leitão,Juliana S. V. Beltrame,Betina M. Selistre,Luciano S. Tasso,Leandro |
author_role |
author |
author2 |
Leitão,Juliana S. V. Beltrame,Betina M. Selistre,Luciano S. Tasso,Leandro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Coser,Thyago A. Leitão,Juliana S. V. Beltrame,Betina M. Selistre,Luciano S. Tasso,Leandro |
dc.subject.por.fl_str_mv |
Acute kidney injury Tomography, X-ray computed Contrast media/adverse effects Contrast media/administration & dosage Iodine radioisotopes Creatinine/blood |
topic |
Acute kidney injury Tomography, X-ray computed Contrast media/adverse effects Contrast media/administration & dosage Iodine radioisotopes Creatinine/blood |
description |
Abstract Objective: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT). Materials and Methods: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2-3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2-7 days after contrast administration. Results: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. We found no association between AKI and the risk factors evaluated. Conclusion: We identified no criteria for contrast-induced nephropathy after CT; nor did we find AKI to be associated with the classical risk factors. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842021000200077 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842021000200077 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-3984.2020.0018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
publisher.none.fl_str_mv |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
dc.source.none.fl_str_mv |
Radiologia Brasileira v.54 n.2 2021 reponame:Radiologia Brasileira (Online) instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) instacron:CBR |
instname_str |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) |
instacron_str |
CBR |
institution |
CBR |
reponame_str |
Radiologia Brasileira (Online) |
collection |
Radiologia Brasileira (Online) |
repository.name.fl_str_mv |
Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) |
repository.mail.fl_str_mv |
radiologiabrasileira@cbr.org.br |
_version_ |
1754208941013729280 |