Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Radiologia Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842015000400006 |
Resumo: | Abstract Objective: To evaluate by magnetic resonance imaging changes in bone marrow of patients undergoing treatment for type I Gaucher’s disease. Materials and Methods: Descriptive, cross-sectional study of Gaucher’s disease patients submitted to 3 T magnetic resonance imaging of femurs and lumbar spine. The images were blindly reviewed and the findings were classified according to the semiquantitative bone marrow burden (BMB) scoring system. Results: All of the seven evaluated patients (three men and four women) presented signs of bone marrow infiltration. Osteonecrosis of the femoral head was found in three patients, Erlenmeyer flask deformity in five, and no patient had vertebral body collapse. The mean BMB score was 11, ranging from 9 to 14. Conclusion: Magnetic resonance imaging is currently the method of choice for assessing bone involvement in Gaucher’s disease in adults due to its high sensitivity to detect both focal and diffuse bone marrow changes, and the BMB score is a simplified method for semiquantitative analysis, without depending on advanced sequences or sophisticated hardware, allowing for the classification of the disease extent and assisting in the treatment monitoring. |
id |
CBR-1_f9d18c59c392c298a0757de788a286bd |
---|---|
oai_identifier_str |
oai:scielo:S0100-39842015000400006 |
network_acronym_str |
CBR-1 |
network_name_str |
Radiologia Brasileira (Online) |
repository_id_str |
|
spelling |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patientsGaucher’s diseaseMagnetic resonance imagingMusculoskeletal systemHematologic diseasesAbstract Objective: To evaluate by magnetic resonance imaging changes in bone marrow of patients undergoing treatment for type I Gaucher’s disease. Materials and Methods: Descriptive, cross-sectional study of Gaucher’s disease patients submitted to 3 T magnetic resonance imaging of femurs and lumbar spine. The images were blindly reviewed and the findings were classified according to the semiquantitative bone marrow burden (BMB) scoring system. Results: All of the seven evaluated patients (three men and four women) presented signs of bone marrow infiltration. Osteonecrosis of the femoral head was found in three patients, Erlenmeyer flask deformity in five, and no patient had vertebral body collapse. The mean BMB score was 11, ranging from 9 to 14. Conclusion: Magnetic resonance imaging is currently the method of choice for assessing bone involvement in Gaucher’s disease in adults due to its high sensitivity to detect both focal and diffuse bone marrow changes, and the BMB score is a simplified method for semiquantitative analysis, without depending on advanced sequences or sophisticated hardware, allowing for the classification of the disease extent and assisting in the treatment monitoring.Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842015000400006Radiologia Brasileira v.48 n.4 2015reponame:Radiologia Brasileira (Online)instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)instacron:CBR10.1590/0100-3984.2014.0068info:eu-repo/semantics/openAccessMello,Ricardo Andrade Fernandes deMello,Melissa Bozzi NonatoPessanha,Laís Bastoseng2020-10-09T00:00:00Zoai:scielo:S0100-39842015000400006Revistahttps://www.scielo.br/j/rb/https://old.scielo.br/oai/scielo-oai.phpradiologiabrasileira@cbr.org.br1678-70990100-3984opendoar:2020-10-09T00:00Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)false |
dc.title.none.fl_str_mv |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
title |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
spellingShingle |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients Mello,Ricardo Andrade Fernandes de Gaucher’s disease Magnetic resonance imaging Musculoskeletal system Hematologic diseases |
title_short |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
title_full |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
title_fullStr |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
title_full_unstemmed |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
title_sort |
Magnetic resonance imaging and BMB score in the evaluation of bone involvement in Gaucher’s disease patients |
author |
Mello,Ricardo Andrade Fernandes de |
author_facet |
Mello,Ricardo Andrade Fernandes de Mello,Melissa Bozzi Nonato Pessanha,Laís Bastos |
author_role |
author |
author2 |
Mello,Melissa Bozzi Nonato Pessanha,Laís Bastos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Mello,Ricardo Andrade Fernandes de Mello,Melissa Bozzi Nonato Pessanha,Laís Bastos |
dc.subject.por.fl_str_mv |
Gaucher’s disease Magnetic resonance imaging Musculoskeletal system Hematologic diseases |
topic |
Gaucher’s disease Magnetic resonance imaging Musculoskeletal system Hematologic diseases |
description |
Abstract Objective: To evaluate by magnetic resonance imaging changes in bone marrow of patients undergoing treatment for type I Gaucher’s disease. Materials and Methods: Descriptive, cross-sectional study of Gaucher’s disease patients submitted to 3 T magnetic resonance imaging of femurs and lumbar spine. The images were blindly reviewed and the findings were classified according to the semiquantitative bone marrow burden (BMB) scoring system. Results: All of the seven evaluated patients (three men and four women) presented signs of bone marrow infiltration. Osteonecrosis of the femoral head was found in three patients, Erlenmeyer flask deformity in five, and no patient had vertebral body collapse. The mean BMB score was 11, ranging from 9 to 14. Conclusion: Magnetic resonance imaging is currently the method of choice for assessing bone involvement in Gaucher’s disease in adults due to its high sensitivity to detect both focal and diffuse bone marrow changes, and the BMB score is a simplified method for semiquantitative analysis, without depending on advanced sequences or sophisticated hardware, allowing for the classification of the disease extent and assisting in the treatment monitoring. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842015000400006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842015000400006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-3984.2014.0068 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
publisher.none.fl_str_mv |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
dc.source.none.fl_str_mv |
Radiologia Brasileira v.48 n.4 2015 reponame:Radiologia Brasileira (Online) instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) instacron:CBR |
instname_str |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) |
instacron_str |
CBR |
institution |
CBR |
reponame_str |
Radiologia Brasileira (Online) |
collection |
Radiologia Brasileira (Online) |
repository.name.fl_str_mv |
Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) |
repository.mail.fl_str_mv |
radiologiabrasileira@cbr.org.br |
_version_ |
1754208938897702912 |