Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Saúde e Pesquisa (Online) |
| Texto Completo: | https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410 |
Resumo: | The objective was to evaluate supplementation with acetyl-L-carnitine (ALC) on myenteric neurons of the ileum of rats after induction of diabetes. Diabetic animals supplemented with ALC (DC), diabetic (D), normoglycemic animals supplemented with ALC (CC) and normoglycemic (C) were used. NADPH-d neurons were quantified and measured. There was a reduction in blood glucose and water intake in the DC group. The neuronal density in 12.72mm² of ileum was similar in the four groups (p>0.05): DC (558.8 ± 220.2), D (513.4 ± 72.01), CC (645.2 ± 144.9) and C (934 ± 248.5). The mean cell body area of neurons (μm²) in diabetic animals, DC (303.9 ± 114.2) and D (285.4 ± 111.8), were greater than in the normoglycemic groups, CC (173.6 ± 53.78) and C (158.4 ± 53.73). The ileum area (mm²) was larger in animals of the diabetic groups, CD (190.96) and D (171.62) compared to the normoglycemic groups: CC (138.04) and C (130.04). However, in the DC group, both areas were larger than in D (p |
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Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-CarnitineAvaliação de neurônios mioentéricos NADPH-diaforase positivos do íleo de ratos diabéticos suplementados com Acetil-L-CarnitinaGastrointestinal tractMyenteric plexusNitric oxidePlexo mioentéricoÓxido nítricoTrato gastrintestinalEnteric neuronsDiabetesThe objective was to evaluate supplementation with acetyl-L-carnitine (ALC) on myenteric neurons of the ileum of rats after induction of diabetes. Diabetic animals supplemented with ALC (DC), diabetic (D), normoglycemic animals supplemented with ALC (CC) and normoglycemic (C) were used. NADPH-d neurons were quantified and measured. There was a reduction in blood glucose and water intake in the DC group. The neuronal density in 12.72mm² of ileum was similar in the four groups (p>0.05): DC (558.8 ± 220.2), D (513.4 ± 72.01), CC (645.2 ± 144.9) and C (934 ± 248.5). The mean cell body area of neurons (μm²) in diabetic animals, DC (303.9 ± 114.2) and D (285.4 ± 111.8), were greater than in the normoglycemic groups, CC (173.6 ± 53.78) and C (158.4 ± 53.73). The ileum area (mm²) was larger in animals of the diabetic groups, CD (190.96) and D (171.62) compared to the normoglycemic groups: CC (138.04) and C (130.04). However, in the DC group, both areas were larger than in D (pObjetivou-se avaliar a suplementação com acetil-L-carnitina (ALC) sobre os neurônios mioentéricos do íleo de ratos após a indução de diabetes. Foram usados animais diabéticos suplementados com ALC (DC), diabéticos (D), normoglicêmicos suplementados com ALC (CC) e normoglicêmicos (C). Neurônios NADPH-d foram quantificados e mensurados. Observou-se redução na glicemia e na ingestão de água no grupo DC. A densidade neuronal em 12,72mm² de íleo foi semelhante nos quatro grupos (p>0,05): DC (558,8 ± 220,2), D (513,4 ± 72,01), CC (645,2 ± 144,9) e C (934 ± 248,5). A área média do corpo celular dos neurônios (μm²) nos animais diabéticos, DC (303,9 ± 114,2) e D (285,4 ± 111,8), foram maiores que nos grupos normoglicêmicos, CC (173,6 ± 53,78) e C (158,4 ± 53,73). A área do íleo (mm²) também mostrou-se maior nos animais dos grupos diabéticos, DC (190,96) e D (171,62) quando comparados aos normoglicêmicos: CC (138,04) e C (130,06). Entretanto no grupo DC, ambas as áreas foram maiores que no D (PUniversidade Cesumar - UniCesumar2021-12-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por Paresinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/841010.17765/2176-9206.2021v14Supl.1.e8410Saúde e Pesquisa; Vol 14 No (Supl. 1) (2021): Supl. 1 - dez. ; 1-13Saúde e Pesquisa; v. 14 n. (Supl. 1) (2021): Supl. 1 - dez. ; 1-132176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporenghttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410/6894https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410/6895Alves, Angela Maria Pereira Defani, Marli Aparecida Alves, Éder Paulo Belato Borges, Stephanie Carvalho Fregonesi, Cristina Elena Prado Teles Stabille, Sandra Regina Miranda Neto, Marcilio Hubner de info:eu-repo/semantics/openAccess2022-08-18T18:21:47Zoai:ojs.pkp.sfu.ca:article/8410Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2022-08-18T18:21:47Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse |
| dc.title.none.fl_str_mv |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine Avaliação de neurônios mioentéricos NADPH-diaforase positivos do íleo de ratos diabéticos suplementados com Acetil-L-Carnitina |
| title |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine |
| spellingShingle |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine Alves, Angela Maria Pereira Gastrointestinal tract Myenteric plexus Nitric oxide Plexo mioentérico Óxido nítrico Trato gastrintestinal Enteric neurons Diabetes |
| title_short |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine |
| title_full |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine |
| title_fullStr |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine |
| title_full_unstemmed |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine |
| title_sort |
Evaluation of positive NADPH-diaphorase myenteric neurons in diabetic rats supplemented with Acetyl-L-Carnitine |
| author |
Alves, Angela Maria Pereira |
| author_facet |
Alves, Angela Maria Pereira Defani, Marli Aparecida Alves, Éder Paulo Belato Borges, Stephanie Carvalho Fregonesi, Cristina Elena Prado Teles Stabille, Sandra Regina Miranda Neto, Marcilio Hubner de |
| author_role |
author |
| author2 |
Defani, Marli Aparecida Alves, Éder Paulo Belato Borges, Stephanie Carvalho Fregonesi, Cristina Elena Prado Teles Stabille, Sandra Regina Miranda Neto, Marcilio Hubner de |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Alves, Angela Maria Pereira Defani, Marli Aparecida Alves, Éder Paulo Belato Borges, Stephanie Carvalho Fregonesi, Cristina Elena Prado Teles Stabille, Sandra Regina Miranda Neto, Marcilio Hubner de |
| dc.subject.por.fl_str_mv |
Gastrointestinal tract Myenteric plexus Nitric oxide Plexo mioentérico Óxido nítrico Trato gastrintestinal Enteric neurons Diabetes |
| topic |
Gastrointestinal tract Myenteric plexus Nitric oxide Plexo mioentérico Óxido nítrico Trato gastrintestinal Enteric neurons Diabetes |
| description |
The objective was to evaluate supplementation with acetyl-L-carnitine (ALC) on myenteric neurons of the ileum of rats after induction of diabetes. Diabetic animals supplemented with ALC (DC), diabetic (D), normoglycemic animals supplemented with ALC (CC) and normoglycemic (C) were used. NADPH-d neurons were quantified and measured. There was a reduction in blood glucose and water intake in the DC group. The neuronal density in 12.72mm² of ileum was similar in the four groups (p>0.05): DC (558.8 ± 220.2), D (513.4 ± 72.01), CC (645.2 ± 144.9) and C (934 ± 248.5). The mean cell body area of neurons (μm²) in diabetic animals, DC (303.9 ± 114.2) and D (285.4 ± 111.8), were greater than in the normoglycemic groups, CC (173.6 ± 53.78) and C (158.4 ± 53.73). The ileum area (mm²) was larger in animals of the diabetic groups, CD (190.96) and D (171.62) compared to the normoglycemic groups: CC (138.04) and C (130.04). However, in the DC group, both areas were larger than in D (p |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-12-20 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado por Pares info:eu-repo/semantics/other |
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article |
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publishedVersion |
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https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410 10.17765/2176-9206.2021v14Supl.1.e8410 |
| url |
https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410 |
| identifier_str_mv |
10.17765/2176-9206.2021v14Supl.1.e8410 |
| dc.language.iso.fl_str_mv |
por eng |
| language |
por eng |
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https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410/6894 https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8410/6895 |
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openAccess |
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application/pdf application/pdf |
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Universidade Cesumar - UniCesumar |
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Universidade Cesumar - UniCesumar |
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Saúde e Pesquisa; Vol 14 No (Supl. 1) (2021): Supl. 1 - dez. ; 1-13 Saúde e Pesquisa; v. 14 n. (Supl. 1) (2021): Supl. 1 - dez. ; 1-13 2176-9206 reponame:Saúde e Pesquisa (Online) instname:Cesumar Diretoria de Pesquisa instacron:CESUMAR |
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Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa |
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naep@cesumar.br |
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