Vitamin D supplementation attenuates acute inflammatory response

Detalhes bibliográficos
Autor(a) principal: Oliveira, Jessica Faggion Pinheiro de
Data de Publicação: 2020
Outros Autores: Cansi, Andrieli, Rocha, Bruno Ambrósio, Bersani-Amado, Ciomar Aparecida, Caparroz-Assef, Silvana Martins
Tipo de documento: Artigo
Idioma: por
Título da fonte: Saúde e Pesquisa (Online)
Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507
Resumo: This study evaluated the effects of daily vitamin D supplementation on the acute inflammatory response in experimental model by different phlogistic agents: carrageenan, prostaglandin and dextran. Animals (rats) orally received (gavage) a single dose of vitamin D or daily supplementation for 7, 15 or 30 days prior to paw edema induced. Vitamin D supplementation for 15 and 30 days significantly reduced the carrageenan-induced inflammatory process, which could be at least partially explained by the reduction of tumor necrosis factor α levels (TNFα). Results indicate that vitamin D supplementation may be a useful therapeutic adjuvant for controlling the acute inflammatory process.
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spelling Vitamin D supplementation attenuates acute inflammatory responseSuplementação com Vitamina D atenua a resposta inflamatória agudaAnti-inflammatoriesCholecalciferolInflammationVitamin DAnti-inflamatóriosColecalciferolInflamaçãoVitamina D.This study evaluated the effects of daily vitamin D supplementation on the acute inflammatory response in experimental model by different phlogistic agents: carrageenan, prostaglandin and dextran. Animals (rats) orally received (gavage) a single dose of vitamin D or daily supplementation for 7, 15 or 30 days prior to paw edema induced. Vitamin D supplementation for 15 and 30 days significantly reduced the carrageenan-induced inflammatory process, which could be at least partially explained by the reduction of tumor necrosis factor α levels (TNFα). Results indicate that vitamin D supplementation may be a useful therapeutic adjuvant for controlling the acute inflammatory process.Este estudo avaliou os efeitos da suplementação diária de vitamina D na resposta inflamatória aguda em modelo experimental por diferentes agentes flogísticos: carragenina, prostaglandina e dextrana. Os animais (ratos) receberam por via oral (gavagem), dose única de vitamina D ou suplementação diária durante 7, 15 ou 30 dias antes da indução do edema de pata. A suplementação com vitamina D por 15 e 30 dias reduziu significativamente o processo inflamatório induzido por carragenina, o que poderia ser explicado, pelo menos parcialmente, pela redução dos níveis de fator de necrose tumoral α (TNFα). Os resultados indicam que a suplementação de vitamina D pode ser um útil adjuvante terapêutico para o controle do processo inflamatório agudo.Universidade Cesumar - UniCesumar2020-06-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por Pares..application/pdfapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/750710.17765/2176-9206.2020v13n2p377-387Saúde e Pesquisa; Vol 13 No 2 (2020): abr./jun.; 377-387Saúde e Pesquisa; v. 13 n. 2 (2020): abr./jun.; 377-3872176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507/6289https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507/6290Oliveira, Jessica Faggion Pinheiro deCansi, AndrieliRocha, Bruno AmbrósioBersani-Amado, Ciomar AparecidaCaparroz-Assef, Silvana Martinsinfo:eu-repo/semantics/openAccess2020-06-12T18:00:10Zoai:ojs.pkp.sfu.ca:article/7507Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2020-06-12T18:00:10Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse
dc.title.none.fl_str_mv Vitamin D supplementation attenuates acute inflammatory response
Suplementação com Vitamina D atenua a resposta inflamatória aguda
title Vitamin D supplementation attenuates acute inflammatory response
spellingShingle Vitamin D supplementation attenuates acute inflammatory response
Oliveira, Jessica Faggion Pinheiro de
Anti-inflammatories
Cholecalciferol
Inflammation
Vitamin D
Anti-inflamatórios
Colecalciferol
Inflamação
Vitamina D
.
title_short Vitamin D supplementation attenuates acute inflammatory response
title_full Vitamin D supplementation attenuates acute inflammatory response
title_fullStr Vitamin D supplementation attenuates acute inflammatory response
title_full_unstemmed Vitamin D supplementation attenuates acute inflammatory response
title_sort Vitamin D supplementation attenuates acute inflammatory response
author Oliveira, Jessica Faggion Pinheiro de
author_facet Oliveira, Jessica Faggion Pinheiro de
Cansi, Andrieli
Rocha, Bruno Ambrósio
Bersani-Amado, Ciomar Aparecida
Caparroz-Assef, Silvana Martins
author_role author
author2 Cansi, Andrieli
Rocha, Bruno Ambrósio
Bersani-Amado, Ciomar Aparecida
Caparroz-Assef, Silvana Martins
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Jessica Faggion Pinheiro de
Cansi, Andrieli
Rocha, Bruno Ambrósio
Bersani-Amado, Ciomar Aparecida
Caparroz-Assef, Silvana Martins
dc.subject.por.fl_str_mv Anti-inflammatories
Cholecalciferol
Inflammation
Vitamin D
Anti-inflamatórios
Colecalciferol
Inflamação
Vitamina D
.
topic Anti-inflammatories
Cholecalciferol
Inflammation
Vitamin D
Anti-inflamatórios
Colecalciferol
Inflamação
Vitamina D
.
description This study evaluated the effects of daily vitamin D supplementation on the acute inflammatory response in experimental model by different phlogistic agents: carrageenan, prostaglandin and dextran. Animals (rats) orally received (gavage) a single dose of vitamin D or daily supplementation for 7, 15 or 30 days prior to paw edema induced. Vitamin D supplementation for 15 and 30 days significantly reduced the carrageenan-induced inflammatory process, which could be at least partially explained by the reduction of tumor necrosis factor α levels (TNFα). Results indicate that vitamin D supplementation may be a useful therapeutic adjuvant for controlling the acute inflammatory process.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por Pares
.
.
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507
10.17765/2176-9206.2020v13n2p377-387
url https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507
identifier_str_mv 10.17765/2176-9206.2020v13n2p377-387
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507/6289
https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/7507/6290
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
dc.source.none.fl_str_mv Saúde e Pesquisa; Vol 13 No 2 (2020): abr./jun.; 377-387
Saúde e Pesquisa; v. 13 n. 2 (2020): abr./jun.; 377-387
2176-9206
reponame:Saúde e Pesquisa (Online)
instname:Cesumar Diretoria de Pesquisa
instacron:CESUMAR
instname_str Cesumar Diretoria de Pesquisa
instacron_str CESUMAR
institution CESUMAR
reponame_str Saúde e Pesquisa (Online)
collection Saúde e Pesquisa (Online)
repository.name.fl_str_mv Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa
repository.mail.fl_str_mv naep@cesumar.br
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