REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2

Detalhes bibliográficos
Autor(a) principal: De Sousa, Ricardo Augusto Leoni
Data de Publicação: 2014
Outros Autores: Pardono, Emerson
Tipo de documento: Artigo
Idioma: por
Título da fonte: Saúde e Pesquisa (Online)
Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449
Resumo: Diabetes mellitus type 2 (DM2) comprises more than 95% of diabetes cases worldwide. It main characteristic is its resistance to insulin which causes the development of hyperglycemia and hyperinsulinemia. Current study analyzes through a revision of the literature the benefits of resisted exercise in the resistance to insulin and its understanding. The key point in DM2 metabolism and its main causes are the protein kinase B (AKT) and Phosphatidylinositol-3-kinase (PI3-K). Resistance to insulin is associated with defects in the activation of receptors of insulin 1 and 2 and/or low activation of PI3-K and/or the slight displacement of GLUT-4, a transporter of glucose. Its intracellular movement depends on AKT signalization. High intensity RE is capable of promoting a greater phosphorylation of insulin receptors and/or increasing the activity of PI3-K and/or raising the translocation of the main glucose vehicle during physical activity and GLUT-4, by a greater activation of AKT. Intense RE strives against insulin resistance and favors a greater and better functioning of the PI3-K pathway.
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spelling REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2Breve Relato da Resistência à Insulina e os Benefícios do Exercício Resistido Intenso no Diabetes Tipo 2Diabetes Mellitus Type 2Resisted ExerciseResistance to Insulin.Diabetes Mellitus Tipo 2Exercício ResistidoResistência à Insulina.Diabetes mellitus type 2 (DM2) comprises more than 95% of diabetes cases worldwide. It main characteristic is its resistance to insulin which causes the development of hyperglycemia and hyperinsulinemia. Current study analyzes through a revision of the literature the benefits of resisted exercise in the resistance to insulin and its understanding. The key point in DM2 metabolism and its main causes are the protein kinase B (AKT) and Phosphatidylinositol-3-kinase (PI3-K). Resistance to insulin is associated with defects in the activation of receptors of insulin 1 and 2 and/or low activation of PI3-K and/or the slight displacement of GLUT-4, a transporter of glucose. Its intracellular movement depends on AKT signalization. High intensity RE is capable of promoting a greater phosphorylation of insulin receptors and/or increasing the activity of PI3-K and/or raising the translocation of the main glucose vehicle during physical activity and GLUT-4, by a greater activation of AKT. Intense RE strives against insulin resistance and favors a greater and better functioning of the PI3-K pathway.O diabetes mellitus tipo 2 (DM2) atinge mais de 95% dos casos de diabetes globalmente. Sua principal característica é a resistência à insulina que é responsável pelo desenvolvimento dos quadros de hiperglicemia e hiperinsulinemia. O objetivo deste estudo foi verificar, através de uma revisão de literatura, os benefícios do exercício resistido (ER) na resistência à insulina e o entendimento desta. O ponto chave no metabolismo do DM2 e seus principais potencializadores são a proteína quinase B (AKT) e a fosfaidilinositol-3-quinase (PI3-K). A resistência à insulina está associada a falhas de ativação dos receptores de insulina 1 e 2 e/ou a baixa ativação da PI3-K e/ou o pouco deslocamento do GLUT-4, que é um transportador de glicose e sua movimentação intracelular depende da sinalização da AKT. O ER de alta intensidade tem a capacidade de promover maior fosforilação dos receptores de insulina e/ou aumenta a atividade da PI3-K e/ou eleva a translocação do principal transportador de glicose durante a atividade física e, após esta, o GLUT-4, através de uma maior ativação da AKT. O ER intenso combate a resistência à insulina e favorece o maior e melhor funcionamento da via da PI3-K.Universidade Cesumar - UniCesumar2014-07-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de Literaturaapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449Saúde e Pesquisa; Vol 7 No 2 (2014): maio/ago.Saúde e Pesquisa; v. 7 n. 2 (2014): maio/ago.2176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449/2383De Sousa, Ricardo Augusto LeoniPardono, Emersoninfo:eu-repo/semantics/openAccess2020-09-04T14:17:00Zoai:ojs.pkp.sfu.ca:article/3449Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2020-09-04T14:17Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse
dc.title.none.fl_str_mv REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
Breve Relato da Resistência à Insulina e os Benefícios do Exercício Resistido Intenso no Diabetes Tipo 2
title REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
spellingShingle REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
De Sousa, Ricardo Augusto Leoni
Diabetes Mellitus Type 2
Resisted Exercise
Resistance to Insulin.
Diabetes Mellitus Tipo 2
Exercício Resistido
Resistência à Insulina
.
title_short REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
title_full REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
title_fullStr REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
title_full_unstemmed REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
title_sort REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2
author De Sousa, Ricardo Augusto Leoni
author_facet De Sousa, Ricardo Augusto Leoni
Pardono, Emerson
author_role author
author2 Pardono, Emerson
author2_role author
dc.contributor.author.fl_str_mv De Sousa, Ricardo Augusto Leoni
Pardono, Emerson
dc.subject.por.fl_str_mv Diabetes Mellitus Type 2
Resisted Exercise
Resistance to Insulin.
Diabetes Mellitus Tipo 2
Exercício Resistido
Resistência à Insulina
.
topic Diabetes Mellitus Type 2
Resisted Exercise
Resistance to Insulin.
Diabetes Mellitus Tipo 2
Exercício Resistido
Resistência à Insulina
.
description Diabetes mellitus type 2 (DM2) comprises more than 95% of diabetes cases worldwide. It main characteristic is its resistance to insulin which causes the development of hyperglycemia and hyperinsulinemia. Current study analyzes through a revision of the literature the benefits of resisted exercise in the resistance to insulin and its understanding. The key point in DM2 metabolism and its main causes are the protein kinase B (AKT) and Phosphatidylinositol-3-kinase (PI3-K). Resistance to insulin is associated with defects in the activation of receptors of insulin 1 and 2 and/or low activation of PI3-K and/or the slight displacement of GLUT-4, a transporter of glucose. Its intracellular movement depends on AKT signalization. High intensity RE is capable of promoting a greater phosphorylation of insulin receptors and/or increasing the activity of PI3-K and/or raising the translocation of the main glucose vehicle during physical activity and GLUT-4, by a greater activation of AKT. Intense RE strives against insulin resistance and favors a greater and better functioning of the PI3-K pathway.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de Literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449
url https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449/2383
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
dc.source.none.fl_str_mv Saúde e Pesquisa; Vol 7 No 2 (2014): maio/ago.
Saúde e Pesquisa; v. 7 n. 2 (2014): maio/ago.
2176-9206
reponame:Saúde e Pesquisa (Online)
instname:Cesumar Diretoria de Pesquisa
instacron:CESUMAR
instname_str Cesumar Diretoria de Pesquisa
instacron_str CESUMAR
institution CESUMAR
reponame_str Saúde e Pesquisa (Online)
collection Saúde e Pesquisa (Online)
repository.name.fl_str_mv Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa
repository.mail.fl_str_mv naep@cesumar.br
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