Candida species cause vulvovaginitis and resistance to antifungals used for treatment

Detalhes bibliográficos
Autor(a) principal: Oliveira, Diogo Luan de
Data de Publicação: 2021
Outros Autores: Schmidt, Juliana Cristina
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Saúde e Pesquisa (Online)
Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022
Resumo: In this study were identified Candida species from vaginal secretion isolates, evaluated their in vitro antifungal susceptibilities, and correlated these features with antifungal agents prescribed for patients assisted in a primary care service. Species identification by Polymerase Chain Reaction showed that 36.5% of isolates were characterized as non-C. albicans species. In antifungal susceptibility tests most isolates were susceptible to ketoconazole, fluconazole, and itraconazole, although between 40% and 50% of isolates show resistance or dose-dependent susceptibility to miconazole and nystatin, respectively. Analysis of drugs prescribed to patients revealed that 34.2% of the isolates were considered resistant to agents used in treatment. Several Candida species can cause vulvovaginitis and exhibit different susceptibility profiles to antifungal drugs used in treatment. The identification of Candida species is relevant and useful to the epidemiological management of infections. The antifungal susceptibility test may also be useful for choosing most effective drug treatment for each patient.
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spelling Candida species cause vulvovaginitis and resistance to antifungals used for treatmentEspécies de Candida causadoras de vulvovaginites e resistência aos antifúngicos utilizados no tratamentoCandida spp.Microbial sensitivity testsPolymerase chain reactionVulvovaginal candidiasisCandidiasisAntifungals susceptibilityCandida spp.Candidíase vulvovaginalReação em cadeia da polimeraseTestes de sensibilidade microbianaCandidiaseSuscetibilidade a antifùngicosIn this study were identified Candida species from vaginal secretion isolates, evaluated their in vitro antifungal susceptibilities, and correlated these features with antifungal agents prescribed for patients assisted in a primary care service. Species identification by Polymerase Chain Reaction showed that 36.5% of isolates were characterized as non-C. albicans species. In antifungal susceptibility tests most isolates were susceptible to ketoconazole, fluconazole, and itraconazole, although between 40% and 50% of isolates show resistance or dose-dependent susceptibility to miconazole and nystatin, respectively. Analysis of drugs prescribed to patients revealed that 34.2% of the isolates were considered resistant to agents used in treatment. Several Candida species can cause vulvovaginitis and exhibit different susceptibility profiles to antifungal drugs used in treatment. The identification of Candida species is relevant and useful to the epidemiological management of infections. The antifungal susceptibility test may also be useful for choosing most effective drug treatment for each patient.Neste estudo foram identificadas espécies de Candida em isolados de secreção vaginal, avaliados os perfis de suscetibilidade in vitro a antifúngicos e correlacionados com os antifúngicos prescritos para pacientes em um serviço de atenção primária. A identificação das espécies pela Reação em Cadeia da Polimerase mostrou que 36,5% dos isolados foram caracterizados como espécie não-C.albicans. Nos testes de sensibilidade a maioria dos isolados foi suscetível a cetoconazol, fluconazol e itraconazol, contudo cerca de 40% e 50% apresentaram resistência ou sensibilidade dose-dependente a miconazol e nistatina, respectivamente. A análise dos fármacos prescritos para as pacientes revelou que 34,2% dos isolados foram considerados resistentes aos agentes utilizados no tratamento. Diversas espécies de Candida podem causar vulvovaginite com variados perfis de suscetibilidade aos antifúngicos comumente utilizados no tratamento. A identificação das espécies de Candida é relevante para o gerenciamento epidemiológico das infecções, além de ser útil, assim como os testes de suscetibilidade, na escolha do tratamento farmacológico mais eficaz para a paciente.Universidade Cesumar - UniCesumar2021-12-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por Paresinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/802210.17765/2176-9206.2021v14Supl.1.e8022Saúde e Pesquisa; Vol 14 No (Supl. 1) (2021): Supl. 1 - dez. ; 1-13Saúde e Pesquisa; v. 14 n. (Supl. 1) (2021): Supl. 1 - dez. ; 1-132176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporenghttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022/6887https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022/6888Oliveira, Diogo Luan deSchmidt, Juliana Cristinainfo:eu-repo/semantics/openAccess2022-08-18T18:21:47Zoai:ojs.pkp.sfu.ca:article/8022Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2022-08-18T18:21:47Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse
dc.title.none.fl_str_mv Candida species cause vulvovaginitis and resistance to antifungals used for treatment
Espécies de Candida causadoras de vulvovaginites e resistência aos antifúngicos utilizados no tratamento
title Candida species cause vulvovaginitis and resistance to antifungals used for treatment
spellingShingle Candida species cause vulvovaginitis and resistance to antifungals used for treatment
Oliveira, Diogo Luan de
Candida spp.
Microbial sensitivity tests
Polymerase chain reaction
Vulvovaginal candidiasis
Candidiasis
Antifungals susceptibility
Candida spp.
Candidíase vulvovaginal
Reação em cadeia da polimerase
Testes de sensibilidade microbiana
Candidiase
Suscetibilidade a antifùngicos
title_short Candida species cause vulvovaginitis and resistance to antifungals used for treatment
title_full Candida species cause vulvovaginitis and resistance to antifungals used for treatment
title_fullStr Candida species cause vulvovaginitis and resistance to antifungals used for treatment
title_full_unstemmed Candida species cause vulvovaginitis and resistance to antifungals used for treatment
title_sort Candida species cause vulvovaginitis and resistance to antifungals used for treatment
author Oliveira, Diogo Luan de
author_facet Oliveira, Diogo Luan de
Schmidt, Juliana Cristina
author_role author
author2 Schmidt, Juliana Cristina
author2_role author
dc.contributor.author.fl_str_mv Oliveira, Diogo Luan de
Schmidt, Juliana Cristina
dc.subject.por.fl_str_mv Candida spp.
Microbial sensitivity tests
Polymerase chain reaction
Vulvovaginal candidiasis
Candidiasis
Antifungals susceptibility
Candida spp.
Candidíase vulvovaginal
Reação em cadeia da polimerase
Testes de sensibilidade microbiana
Candidiase
Suscetibilidade a antifùngicos
topic Candida spp.
Microbial sensitivity tests
Polymerase chain reaction
Vulvovaginal candidiasis
Candidiasis
Antifungals susceptibility
Candida spp.
Candidíase vulvovaginal
Reação em cadeia da polimerase
Testes de sensibilidade microbiana
Candidiase
Suscetibilidade a antifùngicos
description In this study were identified Candida species from vaginal secretion isolates, evaluated their in vitro antifungal susceptibilities, and correlated these features with antifungal agents prescribed for patients assisted in a primary care service. Species identification by Polymerase Chain Reaction showed that 36.5% of isolates were characterized as non-C. albicans species. In antifungal susceptibility tests most isolates were susceptible to ketoconazole, fluconazole, and itraconazole, although between 40% and 50% of isolates show resistance or dose-dependent susceptibility to miconazole and nystatin, respectively. Analysis of drugs prescribed to patients revealed that 34.2% of the isolates were considered resistant to agents used in treatment. Several Candida species can cause vulvovaginitis and exhibit different susceptibility profiles to antifungal drugs used in treatment. The identification of Candida species is relevant and useful to the epidemiological management of infections. The antifungal susceptibility test may also be useful for choosing most effective drug treatment for each patient.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por Pares
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022
10.17765/2176-9206.2021v14Supl.1.e8022
url https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022
identifier_str_mv 10.17765/2176-9206.2021v14Supl.1.e8022
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022/6887
https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/8022/6888
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
dc.source.none.fl_str_mv Saúde e Pesquisa; Vol 14 No (Supl. 1) (2021): Supl. 1 - dez. ; 1-13
Saúde e Pesquisa; v. 14 n. (Supl. 1) (2021): Supl. 1 - dez. ; 1-13
2176-9206
reponame:Saúde e Pesquisa (Online)
instname:Cesumar Diretoria de Pesquisa
instacron:CESUMAR
instname_str Cesumar Diretoria de Pesquisa
instacron_str CESUMAR
institution CESUMAR
reponame_str Saúde e Pesquisa (Online)
collection Saúde e Pesquisa (Online)
repository.name.fl_str_mv Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa
repository.mail.fl_str_mv naep@cesumar.br
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