Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol

Detalhes bibliográficos
Autor(a) principal: Luizetti, Fabiane
Data de Publicação: 2012
Outros Autores: Avancini, Caroline Scilovski, Vargas Filho, Jeronimo Perez, Silva, Tatiane Garcia da, Yamaguchi, Mirian Ueda
Tipo de documento: Artigo
Idioma: por
Título da fonte: Saúde e Pesquisa (Online)
Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144
Resumo: Cresol is a hydrocarbonate and phenol compound used as a highly efficient disinfectant against several bacteria. Cresol has recently been used in experiments in the cure of wounds and tissue recovery. In fact, it features wound healing with neo-vascularization and re-epithelization. Current analysis evaluates the genotoxic effect of cresol in mice’s blood cell by micronucleus test. Sixteen female mice were employed and divided into three groups. The first group was the positive control to which cyclophosphamide at a single dose of 50mg/kg was administered. The second group received a physiological solution 0.9%, as negative control. The third group was treated with cresol. Euthanasia occurred 48 h after treatment and laminas with intracardiac blood were investigated by evaluating 1000 polychromatic erythrocytes for micronucleus counting. Within the concentration tested, cresol is a genotoxic compound that induces alteration in cell DNA and causes the formation of residual micronuclei.
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spelling Genotoxic Effect In Erythrocytes Of Mice Treated Orally With CresolEfeito Genotóxico nos Eritrócitos de Camundongos Tratados com Creolina Via OralGenotoxicityCresolblood cellsMicronucleusGenotoxidadeCreolinaCélulas SanguíneasMicronúcleo.Cresol is a hydrocarbonate and phenol compound used as a highly efficient disinfectant against several bacteria. Cresol has recently been used in experiments in the cure of wounds and tissue recovery. In fact, it features wound healing with neo-vascularization and re-epithelization. Current analysis evaluates the genotoxic effect of cresol in mice’s blood cell by micronucleus test. Sixteen female mice were employed and divided into three groups. The first group was the positive control to which cyclophosphamide at a single dose of 50mg/kg was administered. The second group received a physiological solution 0.9%, as negative control. The third group was treated with cresol. Euthanasia occurred 48 h after treatment and laminas with intracardiac blood were investigated by evaluating 1000 polychromatic erythrocytes for micronucleus counting. Within the concentration tested, cresol is a genotoxic compound that induces alteration in cell DNA and causes the formation of residual micronuclei.A creolina, um composto de hidrocarbonetos, fenol e cresóis, é utilizada como desinfetante de eficácia comprovada contra várias bactérias. A creolina também faz parte de experimentos recentes, não como fator de intoxicação, mas na cura de feridas e sobre reparação tecidual, apresentando uma cicatrização do ferimento, com acentuada neovascularização e reepitelização. Este estudo teve como objetivo avaliar o efeito genotóxico da creolina nas células sanguíneas de camundongos através do teste do micronúcleo. Foram utilizados 16 camundongos fêmeas adultas, divididas em 3 grupos, sendo o primeiro, o grupo controle positivo onde foi administrado ciclofosfamida em dosagem única de 50mg/kg. O segundo grupo recebeu solução fisiológica 0,9%, como controle negativo e o terceiro grupo foi tratado com a creolina. A eutanásia foi realizada 48 horas após os tratamentos e as lâminas confeccionadas com sangue intracardíaco, avaliando 1.000 eritrócitos policromáticos para a contagem de micronúcleos. Na concentração testada, a creolina é uma substância genotóxica capaz de induzir alterações no DNA celular provocando a formação de micronúcleos residuais.Universidade Cesumar - UniCesumar2012-04-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por ParesPesquisaapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144Saúde e Pesquisa; Vol 5 No 3 (2012): set./dez.Saúde e Pesquisa; v. 5 n. 3 (2012): set./dez.2176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144/1798Luizetti, FabianeAvancini, Caroline ScilovskiVargas Filho, Jeronimo PerezSilva, Tatiane Garcia daYamaguchi, Mirian Uedainfo:eu-repo/semantics/openAccess2020-09-04T15:55:19Zoai:ojs.pkp.sfu.ca:article/2144Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2020-09-04T15:55:19Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse
dc.title.none.fl_str_mv Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
Efeito Genotóxico nos Eritrócitos de Camundongos Tratados com Creolina Via Oral
title Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
spellingShingle Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
Luizetti, Fabiane
Genotoxicity
Cresol
blood cells
Micronucleus
Genotoxidade
Creolina
Células Sanguíneas
Micronúcleo
.
title_short Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
title_full Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
title_fullStr Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
title_full_unstemmed Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
title_sort Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol
author Luizetti, Fabiane
author_facet Luizetti, Fabiane
Avancini, Caroline Scilovski
Vargas Filho, Jeronimo Perez
Silva, Tatiane Garcia da
Yamaguchi, Mirian Ueda
author_role author
author2 Avancini, Caroline Scilovski
Vargas Filho, Jeronimo Perez
Silva, Tatiane Garcia da
Yamaguchi, Mirian Ueda
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Luizetti, Fabiane
Avancini, Caroline Scilovski
Vargas Filho, Jeronimo Perez
Silva, Tatiane Garcia da
Yamaguchi, Mirian Ueda
dc.subject.por.fl_str_mv Genotoxicity
Cresol
blood cells
Micronucleus
Genotoxidade
Creolina
Células Sanguíneas
Micronúcleo
.
topic Genotoxicity
Cresol
blood cells
Micronucleus
Genotoxidade
Creolina
Células Sanguíneas
Micronúcleo
.
description Cresol is a hydrocarbonate and phenol compound used as a highly efficient disinfectant against several bacteria. Cresol has recently been used in experiments in the cure of wounds and tissue recovery. In fact, it features wound healing with neo-vascularization and re-epithelization. Current analysis evaluates the genotoxic effect of cresol in mice’s blood cell by micronucleus test. Sixteen female mice were employed and divided into three groups. The first group was the positive control to which cyclophosphamide at a single dose of 50mg/kg was administered. The second group received a physiological solution 0.9%, as negative control. The third group was treated with cresol. Euthanasia occurred 48 h after treatment and laminas with intracardiac blood were investigated by evaluating 1000 polychromatic erythrocytes for micronucleus counting. Within the concentration tested, cresol is a genotoxic compound that induces alteration in cell DNA and causes the formation of residual micronuclei.
publishDate 2012
dc.date.none.fl_str_mv 2012-04-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por Pares
Pesquisa
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144
url https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144/1798
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
publisher.none.fl_str_mv Universidade Cesumar - UniCesumar
dc.source.none.fl_str_mv Saúde e Pesquisa; Vol 5 No 3 (2012): set./dez.
Saúde e Pesquisa; v. 5 n. 3 (2012): set./dez.
2176-9206
reponame:Saúde e Pesquisa (Online)
instname:Cesumar Diretoria de Pesquisa
instacron:CESUMAR
instname_str Cesumar Diretoria de Pesquisa
instacron_str CESUMAR
institution CESUMAR
reponame_str Saúde e Pesquisa (Online)
collection Saúde e Pesquisa (Online)
repository.name.fl_str_mv Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa
repository.mail.fl_str_mv naep@cesumar.br
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