Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Saúde e Pesquisa (Online) |
Texto Completo: | https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1571 |
Resumo: | Alcoholism is a serious disease that affects several organs such as liver, stomach, pancreas, mouth, kidneys, and also the vestibular system. The stomach, the largest segment of the digestive tract, is formed by a kind of pouch located at the left side of the abdominal cavity. Since it carries out chemical and mechanical digestion, it absorbs some substances such as alcohol and drugs. The enteric nervous system functions as a brain located in the gastrointestinal tract (TGI) and shifts the control of the visceral nervous system to the enteric nervous one. In mammals, the myoenteric plexus is located in the muscular wall between the longitudinal and circular muscle layer or slightly shifted to the inside of one of these strata. Current research analyzes the effect of alcohol on the population density of glandular stomach myoenteric neurons of the greater and lesser gastric curvature of rats with chronic alcoholism. Fourteen 90-day-old rats were divided into two groups: control group (seven animals) received water and food during 120 days and the experimental group (seven animals) received a diet of sugarcane liquor during the same period. The animals were then killed and their stomachs removed. Giemsa staining was undertaken for quantitative analysis of neurons and 40 sites of each animal were analyzed. Data were analyzed by Student’s t test, with 5% significance. Experimental animals gained less weight and consumed 7% less food than control animals after a period of 120 days of treatment. The neurons of the alcoholic animals had a lower (29.85%) and a higher (41.7%) mean number of neurons respectively in the lesser and greater gastric curvatures of the alcoholics rats’ stomach. Results show that high neuronal density existed in alcoholic rats’ gastric greater curvature than in their lesser gastric curvature. |
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Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced RatsDensidade Populacional dos Neurônios Mioentéricos da Curvatura Gástrica Maior do Estômago Glandular de Ratos Induzidos ao Alcoolismo CrônicoEnteric NeuronsStomachAlcoholismMyoenteric Plexus.Neurônios EntéricosEstômagoAlcoolismoPlexo Mientérico.Alcoholism is a serious disease that affects several organs such as liver, stomach, pancreas, mouth, kidneys, and also the vestibular system. The stomach, the largest segment of the digestive tract, is formed by a kind of pouch located at the left side of the abdominal cavity. Since it carries out chemical and mechanical digestion, it absorbs some substances such as alcohol and drugs. The enteric nervous system functions as a brain located in the gastrointestinal tract (TGI) and shifts the control of the visceral nervous system to the enteric nervous one. In mammals, the myoenteric plexus is located in the muscular wall between the longitudinal and circular muscle layer or slightly shifted to the inside of one of these strata. Current research analyzes the effect of alcohol on the population density of glandular stomach myoenteric neurons of the greater and lesser gastric curvature of rats with chronic alcoholism. Fourteen 90-day-old rats were divided into two groups: control group (seven animals) received water and food during 120 days and the experimental group (seven animals) received a diet of sugarcane liquor during the same period. The animals were then killed and their stomachs removed. Giemsa staining was undertaken for quantitative analysis of neurons and 40 sites of each animal were analyzed. Data were analyzed by Student’s t test, with 5% significance. Experimental animals gained less weight and consumed 7% less food than control animals after a period of 120 days of treatment. The neurons of the alcoholic animals had a lower (29.85%) and a higher (41.7%) mean number of neurons respectively in the lesser and greater gastric curvatures of the alcoholics rats’ stomach. Results show that high neuronal density existed in alcoholic rats’ gastric greater curvature than in their lesser gastric curvature.O alcoolismo é uma doença grave que acomete diversos órgãos em função dos efeitos nocivos que causa; dentre os mais atingidos estão: fígado, estômago, pâncreas, boca, rins e também o aparelho vestibular. O estômago é o segmento do tubo digestório mais alargado e formado por uma espécie de bolsa, localizada na cavidade abdominal voltada para o lado esquerdo do corpo. Realiza digestão química e mecânica e possui a função de absorção de algumas substâncias como álcool e alguns medicamentos. O sistema nervoso entérico funciona como um cérebro localizado no trato gastrointestinal (TGI), sendo uma forma eficiente de deslocamento do controle visceral do sistema nervoso central para o sistema nervoso entérico. Geralmente em mamíferos o plexo mientérico localiza-se na túnica muscular entre o estrato muscular circular e longitudinal ou levemente deslocado para o interior de um destes estratos. Este estudo teve como objetivo analisar o efeito do álcool sobre a densidade populacional neuronal mioentérica do estômago glandular da curvatura gástrica maior e menor de ratos submetido ao alcoolismo crônico. Utilizou-se 14 ratos com 90 dias de vida, divididos em 2 grupos: grupo controle (7 animais) que receberam durante 120 dias água e ração e o grupo experimental (7 animais) durante 120 dias receberam ração e aguardente de cana. Após este período, os animais foram eutanasiados e os estômagos retirados. Em seguida, realizamos a coloração de Giemsa para análise quantitativa dos neurônios. Para analise quantificamos 40 campos para cada animal. Os dados foram analisados pelo teste t de Student, com significância 5%. Após o período de 120 dias de tratamento verificamos que os animais experimentais ganharam menos peso e ingeriram 7% menos ração que os animais controle. Os neurônios dos animais alcoolizados apresentaram na curvatura gástrica menor em média 29,85 neurônios e na curvatura gástrica maior 41,7. E os animais controle apresentaram na curvatura gástrica menor em média 35,38 neurônios e na curvatura gástrica maior 38,42 neurônios. Com este estudo conclui-se que, na curvatura gástrica maior do estômago de ratos alcoólicos, houve maior densidade neuronal do que na curvatura gástrica menor.Universidade Cesumar - UniCesumar2010-08-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por Paresapplication/pdfhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1571Saúde e Pesquisa; Vol 3 No 3 (2010): set./dez.Saúde e Pesquisa; v. 3 n. 3 (2010): set./dez.2176-9206reponame:Saúde e Pesquisa (Online)instname:Cesumar Diretoria de Pesquisainstacron:CESUMARporhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1571/1145Santos, Alexandre Cezário dosLadoninsky, Lucas HenriqueTochetto, Luana Rosa AngerCarneiro, Joana PaulaOriente, AlesandraBianchi, Fábio JoséOliveira-Bianchi, Larissa Renata deinfo:eu-repo/semantics/openAccess2022-05-20T14:49:05Zoai:ojs.pkp.sfu.ca:article/1571Revistahttps://periodicos.unicesumar.edu.br/index.php/saudpesqPUBhttps://periodicos.unicesumar.edu.br/index.php/saudpesq/oainaep@cesumar.br2176-92061983-1870opendoar:2022-05-20T14:49:05Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisafalse |
dc.title.none.fl_str_mv |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats Densidade Populacional dos Neurônios Mioentéricos da Curvatura Gástrica Maior do Estômago Glandular de Ratos Induzidos ao Alcoolismo Crônico |
title |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats |
spellingShingle |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats Santos, Alexandre Cezário dos Enteric Neurons Stomach Alcoholism Myoenteric Plexus. Neurônios Entéricos Estômago Alcoolismo Plexo Mientérico. |
title_short |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats |
title_full |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats |
title_fullStr |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats |
title_full_unstemmed |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats |
title_sort |
Population Density of Myoenteric Neurons of the Glandular Stomach’s Greater Gastric Curvature of Chronic Alcoholism-Induced Rats |
author |
Santos, Alexandre Cezário dos |
author_facet |
Santos, Alexandre Cezário dos Ladoninsky, Lucas Henrique Tochetto, Luana Rosa Anger Carneiro, Joana Paula Oriente, Alesandra Bianchi, Fábio José Oliveira-Bianchi, Larissa Renata de |
author_role |
author |
author2 |
Ladoninsky, Lucas Henrique Tochetto, Luana Rosa Anger Carneiro, Joana Paula Oriente, Alesandra Bianchi, Fábio José Oliveira-Bianchi, Larissa Renata de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Alexandre Cezário dos Ladoninsky, Lucas Henrique Tochetto, Luana Rosa Anger Carneiro, Joana Paula Oriente, Alesandra Bianchi, Fábio José Oliveira-Bianchi, Larissa Renata de |
dc.subject.por.fl_str_mv |
Enteric Neurons Stomach Alcoholism Myoenteric Plexus. Neurônios Entéricos Estômago Alcoolismo Plexo Mientérico. |
topic |
Enteric Neurons Stomach Alcoholism Myoenteric Plexus. Neurônios Entéricos Estômago Alcoolismo Plexo Mientérico. |
description |
Alcoholism is a serious disease that affects several organs such as liver, stomach, pancreas, mouth, kidneys, and also the vestibular system. The stomach, the largest segment of the digestive tract, is formed by a kind of pouch located at the left side of the abdominal cavity. Since it carries out chemical and mechanical digestion, it absorbs some substances such as alcohol and drugs. The enteric nervous system functions as a brain located in the gastrointestinal tract (TGI) and shifts the control of the visceral nervous system to the enteric nervous one. In mammals, the myoenteric plexus is located in the muscular wall between the longitudinal and circular muscle layer or slightly shifted to the inside of one of these strata. Current research analyzes the effect of alcohol on the population density of glandular stomach myoenteric neurons of the greater and lesser gastric curvature of rats with chronic alcoholism. Fourteen 90-day-old rats were divided into two groups: control group (seven animals) received water and food during 120 days and the experimental group (seven animals) received a diet of sugarcane liquor during the same period. The animals were then killed and their stomachs removed. Giemsa staining was undertaken for quantitative analysis of neurons and 40 sites of each animal were analyzed. Data were analyzed by Student’s t test, with 5% significance. Experimental animals gained less weight and consumed 7% less food than control animals after a period of 120 days of treatment. The neurons of the alcoholic animals had a lower (29.85%) and a higher (41.7%) mean number of neurons respectively in the lesser and greater gastric curvatures of the alcoholics rats’ stomach. Results show that high neuronal density existed in alcoholic rats’ gastric greater curvature than in their lesser gastric curvature. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-08-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1571 |
url |
https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1571 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1571/1145 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Cesumar - UniCesumar |
publisher.none.fl_str_mv |
Universidade Cesumar - UniCesumar |
dc.source.none.fl_str_mv |
Saúde e Pesquisa; Vol 3 No 3 (2010): set./dez. Saúde e Pesquisa; v. 3 n. 3 (2010): set./dez. 2176-9206 reponame:Saúde e Pesquisa (Online) instname:Cesumar Diretoria de Pesquisa instacron:CESUMAR |
instname_str |
Cesumar Diretoria de Pesquisa |
instacron_str |
CESUMAR |
institution |
CESUMAR |
reponame_str |
Saúde e Pesquisa (Online) |
collection |
Saúde e Pesquisa (Online) |
repository.name.fl_str_mv |
Saúde e Pesquisa (Online) - Cesumar Diretoria de Pesquisa |
repository.mail.fl_str_mv |
naep@cesumar.br |
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1754122532046241792 |