HEPATIC EVALU ATION IN WISTAR RATS EXPOSED TO AYAHUASCA TEA

• Autor(a) principal: Acharezzi, Bruno
• Data de Publicação: 2015
• Outros Autores: Tangerino, Gabriela Carolina, Sperandio, Lucas Gabriel, Mestriner, Ana Claudia Dinamarco, Malfará, Wilson Roberto
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde e Pesquisa (Online)
• Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4331
• topic: Ayahuasca Tea; Liver Morphology; Liver Morphometry; Hepatic Enzymes; Hepatic Biochemistry; Chá de Ayahuasca. Morfologia hepática. Morfometria hepática. Enzimas hepáticas. Bioquímica hepática.

Ayahuasca tea is employed in Xamanism, in anti-drug therapy and illicitly in hallucinogenic recreations. Current study assesses the liver histologically and biochemically since it is an organ involved in the metabolism of the tea. Twenty-four male adult Wistar rats were divided into two groups (control and treated). A daily dose four times higher than that used within a religious context was given, during four consecutive days. There was no qualitative morphological change but a reduction of hepatocyte volume and its nucleus occurred when the quantitative analysis of the treated group was performed. Biochemical analysis showed a decrease in gamma-glutamyltransferasis and Alkaline Phosphatase. There were no morphological alterations for dose and exposure time in current study. Morphometric analysis showed significant alterations in hepatocyte volume and its nucleus where a decrease in volume of the treated group occurred when compared to that of control. A significant statistical decrease was detected in the gamma-glutamyl-transferasis and alkaline phosphatase parameters. Current analysis also detected a decrease in hepatocyte volume without alterations in hepatic functions and structure.