EFFECT OF PHOTOBIOMODULATION IN EXTRAPULMONARY CHANGES CAUSED BY EXPERIMENTAL EMPHYSEMA IN Rattus norvegicus

• Autor(a) principal: Fonseca, Khetyma Moreira
• Data de Publicação: 2016
• Outros Autores: Rodrigues, Leonardo de Melo, Ferreira, Danniel Cabral Leão, Vilaça, Márcia Milena Oliveira, Galvão, Suzana Maria Pereira, Alves, Wellington dos Santos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde e Pesquisa (Online)
• Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/4690
• topic: Emphysema; Physiopathology; Animal Models; Papaya Proteinase; Low Intensity Laser Therapy; Emphysema; Physiopathology; Animal Models; Papaya Proteinase; Low Intensity Laser Therapy; Enfisema; Fisiopatologia; Modelos Animais; Papaína; Terapia a Laser de Baixa Intensidade; Enfisema; Fisiopatologia; Modelos Animais; Papaína; Terapia a Laser de Baixa Intensidade

Lung emphysema is a pulmonary inflammatory process, with extrapulmonary repercussions. Twenty-four rats were selected and divided into three groups with eight animals each: control (GC: received only saline solution); group DPOC (GD: with instillation of papaya proteinase 2 mg/kg); group DPOC + laser (GDL: with instillation of papaya proteinase + 15 days of laser therapy). Data analysis comprised: CKMB, LBA, Histology (morphometric analysis) and thickness of the cardiac chambers (morphometric analysis), respectively. The number of inflammatory cells in LBA of GDL decreased (p < 0.05) when compared with GC and GD; there was an increase in CKMB levels in group GD (p < 0.05); significant decrease in GDL (p = 0.0009) when compared to GD, left ventricle hypertrophy (p < 0.05) in group GD and GDL when compared to control. Photobiomodulation decreased the release of inflammatory cells by the release of CKMB in the blood and decreased CKMB levels and reduced myocardial infarction risks.