Morphological Factors that Affect the Development of Diabetes Mellitus Type 1: A Review Of The Literature

• Autor(a) principal: Santos, Barbara Andreo
• Data de Publicação: 2012
• Outros Autores: Lepri, Elaine Rosely
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde e Pesquisa (Online)
• Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2324
• topic: Diabetes Mellitus Type 1; insulin secreting cells; peptide C. Texto 19; Diabetes Mellitus Tipo 1; Células Secretoras de Insulina; Peptídeo C.; .

Diabetes mellitus (DM) is a group of metabolic disorders characterized by chronic hyperglycemia caused by secretion faults and insulin activities. Diabetes mellitus I (DM1) is a disease that causes the chronic destruction of pancreatic beta cells and may be triggered by auto-immune and humor mechanisms and by environmental factors. DM1 is an auto-immune disease, specific to a body organ, which causes the destruction of insulin-producing pancreatic beta cells. The disease is characterized by structural changes in several organic systems, such as retinopathy, nephropathy, neuropathy, coronary diseases, peripheral arterial insufficiency and others. DM1 has several main sequelae such as high blood glucose, increase in the usage of lipids as energy source and decrease in body proteins. When insulin level decreases, the peripheral use of glucose is impaired and its increase in blood causes several effects, such as glycosuria, dehydration, tissue lesions due to structural changes of tissues caused by hyperglycemia, usage of lipids as energy source and metabolic acidosis. Lack or deficient treatment causes serious complications and even death. Current review of the literature describes some factors that affect the development of DM1 in people with regard to the preservation and increase in the beta cell mass with benefits for the treatment