The effects of metformin on gestational obesity and newborn weight

• Autor(a) principal: Nascimento, Iramar Baptistella do
• Data de Publicação: 2017
• Outros Autores: Dienstmann, Guilherme, Souza, Matheus Leite Ramos de, Fleig, Raquel, Silva, Jean Carl
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde e Pesquisa (Online)
• Texto Completo: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/5848
• topic: Metformin; Gestation; Obesity; Newborn.; Metformina; Gestação; Obesidade; Recém-nascido.; Metformina

Which are the most predominant results with the administration of metformin hydrochloride in the high body mass index of the pregnant and in the newborn’s weight? A systematic review of the literature choose from 2000 to 2017 on obesity and the effects of therapy on pregnancy in MEDLINE, LILACS, Embase and Cochrane databases was performed. Among the 2,127 papers initially chosen, only 29 studies presented the criteria established. The outcomes assessed were results of the metformin therapy versus placebo, metformin therapy versus insulin, and the impact of different dosages of metformin used in the researches. The drug presented relevant results in reducing the weight of the mother, but not the newborn. New multi-centre clinical studies are needed as well as an innovative therapeutic strategy regarding the dosages of metformin hydrochloride during the three quarters of pregnancy.