Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion

Detalhes bibliográficos
Autor(a) principal: Santa-Helena, Eduarda
Data de Publicação: 2021
Outros Autores: Wally, Camila, Ribeiro, Joaquim de Paula, Votto, Ana Paula de Souza, Neves Gonçalves, Carla Amorim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of Health & Biological Sciences
Texto Completo: https://periodicos.unichristus.edu.br/jhbs/article/view/3188
Resumo: Objective: In this work, rats isolated hearts were infused EPA before the ischemia period and during reperfusion for available get well in parameter relatives to redox reactions. Methods: The effect of EPA was tested on isolated hearts induced to ischemia and reperfusion, treatment occurred at different times (ischemia or reperfusion). Antioxidant capacity against peroxyl radicals, glutathione cysteine ligase activity, glutathione concentration, lactate dehydrogenase, and creatine kinase concentration was analyzed. Results: Hearts treated with eicosapentaenoic acid had the minor generation of species reactive oxygen and lipid damage after reperfusion. The GSH concentration was higher when the hearts were treated with eicosapentaenoic acid in the period of reperfusion. Conclusion: In conclusion, this study demonstrates that the dose of EPA (20μM) used before ischemia can act as a cardioprotective antioxidant molecule, prevented damage heart from ischemic and reperfusion injury.
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spelling Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusionCiências da SaúdeHeart; Infarction; Myocardium; Omega 3; Oxidative Stress; Ischemia and ReperfusionObjective: In this work, rats isolated hearts were infused EPA before the ischemia period and during reperfusion for available get well in parameter relatives to redox reactions. Methods: The effect of EPA was tested on isolated hearts induced to ischemia and reperfusion, treatment occurred at different times (ischemia or reperfusion). Antioxidant capacity against peroxyl radicals, glutathione cysteine ligase activity, glutathione concentration, lactate dehydrogenase, and creatine kinase concentration was analyzed. Results: Hearts treated with eicosapentaenoic acid had the minor generation of species reactive oxygen and lipid damage after reperfusion. The GSH concentration was higher when the hearts were treated with eicosapentaenoic acid in the period of reperfusion. Conclusion: In conclusion, this study demonstrates that the dose of EPA (20μM) used before ischemia can act as a cardioprotective antioxidant molecule, prevented damage heart from ischemic and reperfusion injury.Instituto para o Desenvolvimento da EducacaoSanta-Helena, EduardaWally, CamilaRibeiro, Joaquim de PaulaVotto, Ana Paula de SouzaNeves Gonçalves, Carla Amorim2021-08-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por ParesPeer ReviewRevisado por paresapplication/pdfhttps://periodicos.unichristus.edu.br/jhbs/article/view/318810.12662/2317-3076jhbs.v9i1.3188.p1-6.2021Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-6Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-6Journal of Health and Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-62317-30762317-308410.12662/2317-3076jhbs.v9i1.2021reponame:Journal of Health & Biological Sciencesinstname:Centro Universitário Christus (Unichristus)instacron:CHRISTUSenghttps://periodicos.unichristus.edu.br/jhbs/article/view/3188/1410Direitos autorais 2021 Journal of Health & Biological Scienceshttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccess2021-12-30T20:32:08Zoai:ojs.unichristus.emnuvens.com.br:article/3188Revistahttps://periodicos.unichristus.edu.br/jhbs/indexPRIhttps://periodicos.unichristus.edu.br/jhbs/oaisecretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br2317-30762317-3084opendoar:2023-01-13T09:47:12.216391Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus)true
dc.title.none.fl_str_mv Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
title Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
spellingShingle Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
Santa-Helena, Eduarda
Ciências da Saúde
Heart; Infarction; Myocardium; Omega 3; Oxidative Stress; Ischemia and Reperfusion
title_short Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
title_full Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
title_fullStr Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
title_full_unstemmed Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
title_sort Cardioprotective effect of eicosapentaenoic acid during ischemia and reperfusion
author Santa-Helena, Eduarda
author_facet Santa-Helena, Eduarda
Wally, Camila
Ribeiro, Joaquim de Paula
Votto, Ana Paula de Souza
Neves Gonçalves, Carla Amorim
author_role author
author2 Wally, Camila
Ribeiro, Joaquim de Paula
Votto, Ana Paula de Souza
Neves Gonçalves, Carla Amorim
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.contributor.author.fl_str_mv Santa-Helena, Eduarda
Wally, Camila
Ribeiro, Joaquim de Paula
Votto, Ana Paula de Souza
Neves Gonçalves, Carla Amorim
dc.subject.none.fl_str_mv
dc.subject.por.fl_str_mv Ciências da Saúde
Heart; Infarction; Myocardium; Omega 3; Oxidative Stress; Ischemia and Reperfusion
topic Ciências da Saúde
Heart; Infarction; Myocardium; Omega 3; Oxidative Stress; Ischemia and Reperfusion
description Objective: In this work, rats isolated hearts were infused EPA before the ischemia period and during reperfusion for available get well in parameter relatives to redox reactions. Methods: The effect of EPA was tested on isolated hearts induced to ischemia and reperfusion, treatment occurred at different times (ischemia or reperfusion). Antioxidant capacity against peroxyl radicals, glutathione cysteine ligase activity, glutathione concentration, lactate dehydrogenase, and creatine kinase concentration was analyzed. Results: Hearts treated with eicosapentaenoic acid had the minor generation of species reactive oxygen and lipid damage after reperfusion. The GSH concentration was higher when the hearts were treated with eicosapentaenoic acid in the period of reperfusion. Conclusion: In conclusion, this study demonstrates that the dose of EPA (20μM) used before ischemia can act as a cardioprotective antioxidant molecule, prevented damage heart from ischemic and reperfusion injury.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por Pares
Peer Review
Revisado por pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unichristus.edu.br/jhbs/article/view/3188
10.12662/2317-3076jhbs.v9i1.3188.p1-6.2021
url https://periodicos.unichristus.edu.br/jhbs/article/view/3188
identifier_str_mv 10.12662/2317-3076jhbs.v9i1.3188.p1-6.2021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.unichristus.edu.br/jhbs/article/view/3188/1410
dc.rights.driver.fl_str_mv Direitos autorais 2021 Journal of Health & Biological Sciences
http://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos autorais 2021 Journal of Health & Biological Sciences
http://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv


dc.publisher.none.fl_str_mv Instituto para o Desenvolvimento da Educacao
publisher.none.fl_str_mv Instituto para o Desenvolvimento da Educacao
dc.source.none.fl_str_mv Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-6
Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-6
Journal of Health and Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-6
2317-3076
2317-3084
10.12662/2317-3076jhbs.v9i1.2021
reponame:Journal of Health & Biological Sciences
instname:Centro Universitário Christus (Unichristus)
instacron:CHRISTUS
instname_str Centro Universitário Christus (Unichristus)
instacron_str CHRISTUS
institution CHRISTUS
reponame_str Journal of Health & Biological Sciences
collection Journal of Health & Biological Sciences
repository.name.fl_str_mv Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus)
repository.mail.fl_str_mv secretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br
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