Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Journal of Health & Biological Sciences |
Texto Completo: | https://periodicos.unichristus.edu.br/jhbs/article/view/3864 |
Resumo: | Objective: To evaluate the occurrence of hematological and functional toxicities during chemotherapy with doxorubicin and cyclophosphamide in women with breast invasive ductal carcinoma. Methods: This was a descriptive, cross-sectional and quantitative study, involving the data collection in clinical records of 119 women undergoing chemotherapy for breast invasive ductal carcinoma in an oncology outpatient clinic, carried out between February 2014 and February 2015. Results: The investigated toxicities and their respectively occurrences in patients exposed to doxorubicin and cyclophosphamide were hemoglobinemia (26,5%), leukopenia (21,6%), neutropenia (10,8%), thrombocytopenia (none) and reduced hematocrit (28,4%), in addition to fatigue (93,1%), fever (20,6%), gain (35,3%) and weight loss (22,5%). In these variables, there were no significant differences between the exposed and not exposed patients. The association with taxanes showed a significant reduction in hematocrit values (p=0.019) and the toxicities distributed by age group were not significant within the exposed group. Conclusions: Exposure to doxorubicin and cyclophosphamide was not associated with an increase in the occurrence of hematotoxicities and functional impacts in women with breast ductal invasive carcinoma, except when associated with taxane agents. |
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Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical recordsCiências da SaúdeBreast Neoplasms; Antineoplastic Agents; ToxicityObjective: To evaluate the occurrence of hematological and functional toxicities during chemotherapy with doxorubicin and cyclophosphamide in women with breast invasive ductal carcinoma. Methods: This was a descriptive, cross-sectional and quantitative study, involving the data collection in clinical records of 119 women undergoing chemotherapy for breast invasive ductal carcinoma in an oncology outpatient clinic, carried out between February 2014 and February 2015. Results: The investigated toxicities and their respectively occurrences in patients exposed to doxorubicin and cyclophosphamide were hemoglobinemia (26,5%), leukopenia (21,6%), neutropenia (10,8%), thrombocytopenia (none) and reduced hematocrit (28,4%), in addition to fatigue (93,1%), fever (20,6%), gain (35,3%) and weight loss (22,5%). In these variables, there were no significant differences between the exposed and not exposed patients. The association with taxanes showed a significant reduction in hematocrit values (p=0.019) and the toxicities distributed by age group were not significant within the exposed group. Conclusions: Exposure to doxorubicin and cyclophosphamide was not associated with an increase in the occurrence of hematotoxicities and functional impacts in women with breast ductal invasive carcinoma, except when associated with taxane agents.Instituto para o Desenvolvimento da EducacaoKameo, Simone YurikoRamos, Maria Júlia OliveiraLima, Ricardo BarbosaAmorim, Bruno FerreiraCosta, Jéssica dos SantosMarinho, Pabliane Matias LordeloSawada, Namie OkinoSilva, Glebson Moura2021-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por ParesPeer ReviewRevisado por paresapplication/pdfhttps://periodicos.unichristus.edu.br/jhbs/article/view/386410.12662/2317-3076jhbs.v9i1.3864.p1-8.2021Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-8Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-8Journal of Health and Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-82317-30762317-308410.12662/2317-3076jhbs.v9i1.2021reponame:Journal of Health & Biological Sciencesinstname:Centro Universitário Christus (Unichristus)instacron:CHRISTUSporhttps://periodicos.unichristus.edu.br/jhbs/article/view/3864/1510https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/3864/1134https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/3864/1135https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/3864/1136Direitos autorais 2021 Journal of Health & Biological Scienceshttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccess2021-12-30T22:22:58Zoai:ojs.unichristus.emnuvens.com.br:article/3864Revistahttps://periodicos.unichristus.edu.br/jhbs/indexPRIhttps://periodicos.unichristus.edu.br/jhbs/oaisecretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br2317-30762317-3084opendoar:2023-01-13T09:47:31.855295Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus)true |
dc.title.none.fl_str_mv |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
title |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
spellingShingle |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records Kameo, Simone Yuriko Ciências da Saúde Breast Neoplasms; Antineoplastic Agents; Toxicity |
title_short |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
title_full |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
title_fullStr |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
title_full_unstemmed |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
title_sort |
Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records |
author |
Kameo, Simone Yuriko |
author_facet |
Kameo, Simone Yuriko Ramos, Maria Júlia Oliveira Lima, Ricardo Barbosa Amorim, Bruno Ferreira Costa, Jéssica dos Santos Marinho, Pabliane Matias Lordelo Sawada, Namie Okino Silva, Glebson Moura |
author_role |
author |
author2 |
Ramos, Maria Júlia Oliveira Lima, Ricardo Barbosa Amorim, Bruno Ferreira Costa, Jéssica dos Santos Marinho, Pabliane Matias Lordelo Sawada, Namie Okino Silva, Glebson Moura |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Kameo, Simone Yuriko Ramos, Maria Júlia Oliveira Lima, Ricardo Barbosa Amorim, Bruno Ferreira Costa, Jéssica dos Santos Marinho, Pabliane Matias Lordelo Sawada, Namie Okino Silva, Glebson Moura |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
Ciências da Saúde Breast Neoplasms; Antineoplastic Agents; Toxicity |
topic |
Ciências da Saúde Breast Neoplasms; Antineoplastic Agents; Toxicity |
description |
Objective: To evaluate the occurrence of hematological and functional toxicities during chemotherapy with doxorubicin and cyclophosphamide in women with breast invasive ductal carcinoma. Methods: This was a descriptive, cross-sectional and quantitative study, involving the data collection in clinical records of 119 women undergoing chemotherapy for breast invasive ductal carcinoma in an oncology outpatient clinic, carried out between February 2014 and February 2015. Results: The investigated toxicities and their respectively occurrences in patients exposed to doxorubicin and cyclophosphamide were hemoglobinemia (26,5%), leukopenia (21,6%), neutropenia (10,8%), thrombocytopenia (none) and reduced hematocrit (28,4%), in addition to fatigue (93,1%), fever (20,6%), gain (35,3%) and weight loss (22,5%). In these variables, there were no significant differences between the exposed and not exposed patients. The association with taxanes showed a significant reduction in hematocrit values (p=0.019) and the toxicities distributed by age group were not significant within the exposed group. Conclusions: Exposure to doxorubicin and cyclophosphamide was not associated with an increase in the occurrence of hematotoxicities and functional impacts in women with breast ductal invasive carcinoma, except when associated with taxane agents. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado por Pares Peer Review Revisado por pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.unichristus.edu.br/jhbs/article/view/3864 10.12662/2317-3076jhbs.v9i1.3864.p1-8.2021 |
url |
https://periodicos.unichristus.edu.br/jhbs/article/view/3864 |
identifier_str_mv |
10.12662/2317-3076jhbs.v9i1.3864.p1-8.2021 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.unichristus.edu.br/jhbs/article/view/3864/1510 https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/3864/1134 https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/3864/1135 https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/3864/1136 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2021 Journal of Health & Biological Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2021 Journal of Health & Biological Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
|
dc.publisher.none.fl_str_mv |
Instituto para o Desenvolvimento da Educacao |
publisher.none.fl_str_mv |
Instituto para o Desenvolvimento da Educacao |
dc.source.none.fl_str_mv |
Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-8 Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-8 Journal of Health and Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-8 2317-3076 2317-3084 10.12662/2317-3076jhbs.v9i1.2021 reponame:Journal of Health & Biological Sciences instname:Centro Universitário Christus (Unichristus) instacron:CHRISTUS |
instname_str |
Centro Universitário Christus (Unichristus) |
instacron_str |
CHRISTUS |
institution |
CHRISTUS |
reponame_str |
Journal of Health & Biological Sciences |
collection |
Journal of Health & Biological Sciences |
repository.name.fl_str_mv |
Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus) |
repository.mail.fl_str_mv |
secretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br |
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1797052857046794240 |