ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Científica do CRO-RJ (Online) |
Texto Completo: | https://cro-rj.org.br/revcientifica/index.php/revista/article/view/91 |
Resumo: | Objective: Through a systematic review and meta-analysis, the aim this study was evaluating the association between the P561T polymorphism in GHR (rs6184) with skeletal Class III malocclusion in different populations. Methods: A broad search for studies was conducted using the databases: PubMed, Web of Science, Scopus, Cochrane, Google Scholar and Open Grey until December 2018. The study design according to PECOS was: P-Orthodontic patients; E- polymorphism P561T in GHR; C- absence of polymorphism P561T in GHR; O- linear dimension alterations in maxilla and mandibular measurements; S- Cross-sectional studies. The selected studies were qualified by 10-point scoring sheet methodological quality. The subgroups evaluation was performed according to the linear measurements evaluated in two or more studies, as follows: body height, N-S, A’-PTM’, Gn-Go, Pog’-Go, and Co-Go.A fixed effect model was used and the mean differences were performed using the inverse-variance meta-analysis. The I2 (95%) was used to measure statistical heterogeneity between studies, where I2 values of 25%, 50%, and 75% signified low, medium, and high heterogeneity, respectively. Results: The initial search identified 146 studies. After excluding duplicateabstracts, 138 were selected. Seven studies were included in the systematic review. Only one study was classified as having low methodological quality. Three studies were included in the meta-analysis. The meta-analysis demonstrated an association between the Co-Go linear measure and CC genotype (p<0.0001), with a mean difference and confidence interval of 3.79 [2.06, 5.52]. CC was associated with greater mandibularheight. Conclusion: The polymorphism P561T in GHR is associated with Co-Go measurement in Asians, with low level of evidence. |
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ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSISASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSISGenetic Polymorphism; Angle class III; Prognathism;, Single nucleotide; Somatotropin-binding protein.Polimorfismo Genético; Classe III de Angle; Prognatismo; Nucleotídeo único; Proteína ligante à Somatotropina.Objective: Through a systematic review and meta-analysis, the aim this study was evaluating the association between the P561T polymorphism in GHR (rs6184) with skeletal Class III malocclusion in different populations. Methods: A broad search for studies was conducted using the databases: PubMed, Web of Science, Scopus, Cochrane, Google Scholar and Open Grey until December 2018. The study design according to PECOS was: P-Orthodontic patients; E- polymorphism P561T in GHR; C- absence of polymorphism P561T in GHR; O- linear dimension alterations in maxilla and mandibular measurements; S- Cross-sectional studies. The selected studies were qualified by 10-point scoring sheet methodological quality. The subgroups evaluation was performed according to the linear measurements evaluated in two or more studies, as follows: body height, N-S, A’-PTM’, Gn-Go, Pog’-Go, and Co-Go.A fixed effect model was used and the mean differences were performed using the inverse-variance meta-analysis. The I2 (95%) was used to measure statistical heterogeneity between studies, where I2 values of 25%, 50%, and 75% signified low, medium, and high heterogeneity, respectively. Results: The initial search identified 146 studies. After excluding duplicateabstracts, 138 were selected. Seven studies were included in the systematic review. Only one study was classified as having low methodological quality. Three studies were included in the meta-analysis. The meta-analysis demonstrated an association between the Co-Go linear measure and CC genotype (p<0.0001), with a mean difference and confidence interval of 3.79 [2.06, 5.52]. CC was associated with greater mandibularheight. Conclusion: The polymorphism P561T in GHR is associated with Co-Go measurement in Asians, with low level of evidence.Objetivo: Por meio de uma revisão sistemática e meta-análise, o objetivo deste estudo foi avaliar a associação entre o polimorfismo P561T em GHR (rs6184) com a maloclusão de Classe III esquelética em diferentes populações. Métodos: Uma ampla pesquisa de estudos foi realizada utilizando os bancos de dados PubMed, Web of Science, Scopus, Cochrane, Google Scholar e Open Grey até dezembro de 2018. O desenho do estudo de acordo com o PECOS foi: P-Pacientes ortodônticos; Polimorfismo P561T em GHR; Causênciade polimorfismo P561T em GHR ; O-alterações na dimensão linear das medidas maxilares e mandibulares; S- Estudos transversais. Os estudos selecionados foram qualificados pela qualidade metodológica em uma escala de 10 pontos. A avaliação em subgrupos. O subgrupo foi realizada de acordo com as medidas lineares avaliadas em dois ou mais estudos, como a seguir: altura corporal, N-S, A’-PTM ‘, Gn-Go, Pog’-Go. Foiutilizado o modelo de efeito fixo e as diferenças médias foram realizada usando a metanálise de variância inversa. O I2 (95%) foi utilizado para medir heterogeneidade estatística entre estudos, em que valores de I2 de 25%, 50% e 75% significaram baixa, média e alta heterogeneidade, respectivamente. Resultados: A pesquisa inicial identificou 146 estudos. Após excluir resumos duplicados, 138 foram selecionados. Seteestudos foram incluídos na revisão sistemática. Apenas 1 estudo foi classificado como de baixa qualidade metodológica. Três estudos foram incluídos na meta-análise. A metaanálise demonstrou uma associação entre a medida linear Co-Go e o genótipo CC (p<0,0001), com diferença média e intervalo de confiança de 3,79 [2,06; 5,52]. CC foi associado com maior altura mandibular. Conclusão: O polimorfismo P561T em GHRestá associado à medida Co-Go em asiáticos, com baixo nível de evidência.Rio de Janeiro Dental Journal2019-10-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://cro-rj.org.br/revcientifica/index.php/revista/article/view/9110.29327/24816.4.2-2Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal); Vol. 4 No. 2: May-August 2019; 2-11Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal); v. 4 n. 2: May-August 2019; 2-112595-47331518-524910.29327/24816.4.2reponame:Revista Científica do CRO-RJ (Online)instname:Conselho Regional de Odontologia do Rio de Janeiro (CRO-RJ)instacron:CROporhttps://cro-rj.org.br/revcientifica/index.php/revista/article/view/91/66Copyright (c) 2019 Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal)info:eu-repo/semantics/openAccessNascimento, Mariele Andrade doOliveira, Daniela Silva Barroso deReis, Caio Luiz BitencourtMaria Wambier, LetíciaHorta, Karla CarpioRomano, Fabio LourençoSilva, Léa Assed Bezerra daSilva, Raquel Assed Bezerra daNelson-Filho, PauloKuchler, Erika Calvano2019-12-09T18:57:11Zoai:ojs3.cro-rj.org.br:article/91Revistahttps://cro-rj.org.br/revcientifica/index.php/revistahttps://cro-rj.org.br/revcientifica/index.php/revista/oairevista.cientifica@cro-rj.org.br || rorefa@terra.com.br2595-47331518-5249opendoar:2019-12-09T18:57:11Revista Científica do CRO-RJ (Online) - Conselho Regional de Odontologia do Rio de Janeiro (CRO-RJ)false |
dc.title.none.fl_str_mv |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
title |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
spellingShingle |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS Nascimento, Mariele Andrade do Genetic Polymorphism; Angle class III; Prognathism;, Single nucleotide; Somatotropin-binding protein. Polimorfismo Genético; Classe III de Angle; Prognatismo; Nucleotídeo único; Proteína ligante à Somatotropina. |
title_short |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
title_full |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
title_fullStr |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
title_full_unstemmed |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
title_sort |
ASSOCIATION BETWEEN P561T POLYMORPHISM IN GROWTH HORMONE RECEPTOR GENE AND MANDIBULAR PROGNATHISM: SYSTEMATIC REVIEW AND METAANALYSIS |
author |
Nascimento, Mariele Andrade do |
author_facet |
Nascimento, Mariele Andrade do Oliveira, Daniela Silva Barroso de Reis, Caio Luiz Bitencourt Maria Wambier, Letícia Horta, Karla Carpio Romano, Fabio Lourenço Silva, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Nelson-Filho, Paulo Kuchler, Erika Calvano |
author_role |
author |
author2 |
Oliveira, Daniela Silva Barroso de Reis, Caio Luiz Bitencourt Maria Wambier, Letícia Horta, Karla Carpio Romano, Fabio Lourenço Silva, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Nelson-Filho, Paulo Kuchler, Erika Calvano |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento, Mariele Andrade do Oliveira, Daniela Silva Barroso de Reis, Caio Luiz Bitencourt Maria Wambier, Letícia Horta, Karla Carpio Romano, Fabio Lourenço Silva, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Nelson-Filho, Paulo Kuchler, Erika Calvano |
dc.subject.por.fl_str_mv |
Genetic Polymorphism; Angle class III; Prognathism;, Single nucleotide; Somatotropin-binding protein. Polimorfismo Genético; Classe III de Angle; Prognatismo; Nucleotídeo único; Proteína ligante à Somatotropina. |
topic |
Genetic Polymorphism; Angle class III; Prognathism;, Single nucleotide; Somatotropin-binding protein. Polimorfismo Genético; Classe III de Angle; Prognatismo; Nucleotídeo único; Proteína ligante à Somatotropina. |
description |
Objective: Through a systematic review and meta-analysis, the aim this study was evaluating the association between the P561T polymorphism in GHR (rs6184) with skeletal Class III malocclusion in different populations. Methods: A broad search for studies was conducted using the databases: PubMed, Web of Science, Scopus, Cochrane, Google Scholar and Open Grey until December 2018. The study design according to PECOS was: P-Orthodontic patients; E- polymorphism P561T in GHR; C- absence of polymorphism P561T in GHR; O- linear dimension alterations in maxilla and mandibular measurements; S- Cross-sectional studies. The selected studies were qualified by 10-point scoring sheet methodological quality. The subgroups evaluation was performed according to the linear measurements evaluated in two or more studies, as follows: body height, N-S, A’-PTM’, Gn-Go, Pog’-Go, and Co-Go.A fixed effect model was used and the mean differences were performed using the inverse-variance meta-analysis. The I2 (95%) was used to measure statistical heterogeneity between studies, where I2 values of 25%, 50%, and 75% signified low, medium, and high heterogeneity, respectively. Results: The initial search identified 146 studies. After excluding duplicateabstracts, 138 were selected. Seven studies were included in the systematic review. Only one study was classified as having low methodological quality. Three studies were included in the meta-analysis. The meta-analysis demonstrated an association between the Co-Go linear measure and CC genotype (p<0.0001), with a mean difference and confidence interval of 3.79 [2.06, 5.52]. CC was associated with greater mandibularheight. Conclusion: The polymorphism P561T in GHR is associated with Co-Go measurement in Asians, with low level of evidence. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cro-rj.org.br/revcientifica/index.php/revista/article/view/91 10.29327/24816.4.2-2 |
url |
https://cro-rj.org.br/revcientifica/index.php/revista/article/view/91 |
identifier_str_mv |
10.29327/24816.4.2-2 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://cro-rj.org.br/revcientifica/index.php/revista/article/view/91/66 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Rio de Janeiro Dental Journal |
publisher.none.fl_str_mv |
Rio de Janeiro Dental Journal |
dc.source.none.fl_str_mv |
Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal); Vol. 4 No. 2: May-August 2019; 2-11 Revista Científica do CRO-RJ (Rio de Janeiro Dental Journal); v. 4 n. 2: May-August 2019; 2-11 2595-4733 1518-5249 10.29327/24816.4.2 reponame:Revista Científica do CRO-RJ (Online) instname:Conselho Regional de Odontologia do Rio de Janeiro (CRO-RJ) instacron:CRO |
instname_str |
Conselho Regional de Odontologia do Rio de Janeiro (CRO-RJ) |
instacron_str |
CRO |
institution |
CRO |
reponame_str |
Revista Científica do CRO-RJ (Online) |
collection |
Revista Científica do CRO-RJ (Online) |
repository.name.fl_str_mv |
Revista Científica do CRO-RJ (Online) - Conselho Regional de Odontologia do Rio de Janeiro (CRO-RJ) |
repository.mail.fl_str_mv |
revista.cientifica@cro-rj.org.br || rorefa@terra.com.br |
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1797042306211119104 |