The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths

Detalhes bibliográficos
Autor(a) principal: Periago, Maria Victoria
Data de Publicação: 2015
Outros Autores: Diniz, Renata Caldeira, Pinto, Simone Aparecida, Yakovleva, Anna, Oliveira, Rodrigo Correa de, Diemert, David J., Bethony, Jeffrey Michael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12799
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
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spelling Periago, Maria VictoriaDiniz, Renata CaldeiraPinto, Simone AparecidaYakovleva, AnnaOliveira, Rodrigo Correa deDiemert, David J.Bethony, Jeffrey Michael2016-02-23T17:38:27Z2016-02-23T17:38:27Z2015PERIAGO, Maria Victoria et al. The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths. PLoS Neglected Tropical Diseases, v. 9, n. 8, p. 1-15, 2015.1935-2735https://www.arca.fiocruz.br/handle/icict/1279910.1371/journal.pntd.0003967engPublic Library of ScienceThe Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminthsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.George Washington University. School of Medicine and Health Science. Research Center for the Neglected Diseases of Poverty. Washington, DC, USA / George Washington University. School of Medicine and Health Science. Department of Microbiology, Immunology and Tropical Medicine. Washington, DC, USA.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.George Washington University. School of Medicine and Health Science. Research Center for the Neglected Diseases of Poverty. Washington, DC, USA / George Washington University. School of Medicine and Health Science. Department of Microbiology, Immunology and Tropical Medicine. Washington, DC, USA.George Washington University. School of Medicine and Health Science. Research Center for the Neglected Diseases of Poverty. Washington, DC, USA / George Washington University. School of Medicine and Health Science. Department of Microbiology, Immunology and Tropical Medicine. Washington, DC, USA.BACKGROUND: Due to the recent increased use of the McMaster (MM) fecal egg counting method for assessing benzimidazole drug efficacy for treating soil-transmitted helminth (STH) infections, the aim of the current study was to determine the operational value of including the MM method alongside the Kato-Katz (KK) fecal thick smear to increase the diagnostic sensitivity when STHs are co-endemic with trematode helminths (e.g., Schistosoma mansoni). METHODS: A cross-sectional study was conducted in school-aged children aged 4-18 years in the northeastern region of the State of Minas Gerais (Brazil), where Necator americanus, Ascaris lumbricoides, Trichuris trichiura, and S. mansoni are co-endemic. One fecal sample from each participant was collected and transported to the field laboratory for analysis. Coprological diagnosis was performed on each fecal sample by three different methods: Formalin-Ether Sedimentation (FES), KK and the MM technique. The diagnostic sensitivity and negative predictive value (NPV) of each technique was calculated using the combination of all three techniques as the composite standard. In order to determine the agreement between the three techniques Fleiss´ kappa was used. Both the Cure Rate (CR) and the Fecal Egg Count Reduction (FECR) were calculated using the two quantification techniques (i.e., the MM and KK). RESULTS: Fecal samples from 1260 children were analyzed. The KK had higher diagnostic sensitivity than the MM for the detection of both A. lumbricoides (KK 97.3%, MM 69.5%) and hookworm (KK 95.1%, MM 80.8%). The CR of a single dose of mebendazole varied significantly between the KK and MM for both A. lumbricoides (p = 0.016) and hookworm p = 0.000), with lower rates obtained with the KK. On the other hand, the FECR was very similar between both techniques for both A. lumbricoides and hookworm. CONCLUSION: The MM did not add any diagnostic value over the KK in areas where both STHs and trematodes were co-endemic. The lower sensitivity of the MM would have an important impact on the administration of selective school-based treatment in this area since if only the MM were used, 36 (13.9%) children diagnosed with A. lumbricoides would have gone untreated.HelmintiasisKato-Katzinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12799/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThe Right Tool for the Job.pdfThe Right Tool for the Job.pdfapplication/pdf5563074https://www.arca.fiocruz.br/bitstream/icict/12799/2/The%20Right%20Tool%20for%20the%20Job.pdf28030dcfbae000338419031cdcc38ed8MD52TEXTThe Right Tool for the Job.pdf.txtThe Right Tool for the Job.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
title The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
spellingShingle The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
Periago, Maria Victoria
Helmintiasis
Kato-Katz
title_short The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
title_full The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
title_fullStr The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
title_full_unstemmed The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
title_sort The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths
author Periago, Maria Victoria
author_facet Periago, Maria Victoria
Diniz, Renata Caldeira
Pinto, Simone Aparecida
Yakovleva, Anna
Oliveira, Rodrigo Correa de
Diemert, David J.
Bethony, Jeffrey Michael
author_role author
author2 Diniz, Renata Caldeira
Pinto, Simone Aparecida
Yakovleva, Anna
Oliveira, Rodrigo Correa de
Diemert, David J.
Bethony, Jeffrey Michael
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Periago, Maria Victoria
Diniz, Renata Caldeira
Pinto, Simone Aparecida
Yakovleva, Anna
Oliveira, Rodrigo Correa de
Diemert, David J.
Bethony, Jeffrey Michael
dc.subject.en.pt_BR.fl_str_mv Helmintiasis
Kato-Katz
topic Helmintiasis
Kato-Katz
description Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-02-23T17:38:27Z
dc.date.available.fl_str_mv 2016-02-23T17:38:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PERIAGO, Maria Victoria et al. The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths. PLoS Neglected Tropical Diseases, v. 9, n. 8, p. 1-15, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12799
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0003967
identifier_str_mv PERIAGO, Maria Victoria et al. The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths. PLoS Neglected Tropical Diseases, v. 9, n. 8, p. 1-15, 2015.
1935-2735
10.1371/journal.pntd.0003967
url https://www.arca.fiocruz.br/handle/icict/12799
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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