Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review

Detalhes bibliográficos
Autor(a) principal: Borges, Juliana Pereira
Data de Publicação: 2015
Outros Autores: Lessa, Marcos Adriano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13841
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
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spelling Borges, Juliana PereiraLessa, Marcos Adriano2016-04-18T12:45:49Z2016-04-18T12:45:49Z2015BORGES, Juliana Pereira; LESSA, Marcos Adriano. Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review. Arq. Bras Cardiol., v.105, n.1, p.71-81, 2015.0066-782Xhttps://www.arca.fiocruz.br/handle/icict/1384110.5935/abc.201500241678-4170engSociedade Brasileira de Cardiologia - SBCMechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Background: Acute myocardial infarction is the leading cause of morbidity and mortality worldwide. Furthermore, research has shown that exercise, in addition to reducing cardiovascular risk factors, can also protect the heart against injury due to ischemia and reperfusion through a direct effect on the myocardium. However, the specific mechanism involved in exerciseinduced cardiac preconditioning is still under debate. Objective: To perform a systematic review of the studies that have addressed the mechanisms by which aerobic exercise promotes direct cardioprotection against ischemia and reperfusion injury. Methods: A search was conducted using MEDLINE, Literatura Latino-Americana e do Caribe de Informação em Ciências da Saúde, and Scientific Electronic Library Online databases. Data were extracted in a standardized manner by two independent researchers, who were responsible for assessing the methodological quality of the studies. Results: The search retrieved 78 studies; after evaluating the abstracts, 30 studies were excluded. The manuscripts of the remaining 48 studies were completely read and, of these, 20 were excluded. Finally, 28 studies were included in this systematic review. Conclusion: On the basis of the selected studies, the following are potentially involved in the cardioprotective response to exercise: increased heat shock protein production, nitric oxide pathway involvement, increased cardiac antioxidant capacity, improvement in ATP-dependent potassium channel function, and opioid system activation. Despite all the previous investigations, further research is still necessary to obtain more consistent conclusions.Myocardial InfarctionExercise/physiologyMyocardial Reperfusion Injury/etiologyMyocardial IschemiaHeat-Shock ProteinsInfarto do MiocárdioReperfusão MiocárdicaTraumatismo por Reperfusão MiocárdicaIsquemia MiocárdicaProteínas de Choque Térmicoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13841/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjuliana_borgeselessa_IOC-2015.pdfjuliana_borgeselessa_IOC-2015.pdfapplication/pdf839675https://www.arca.fiocruz.br/bitstream/icict/13841/2/juliana_borgeselessa_IOC-2015.pdf356e5eb10b4494ec98df55bf35e44f9fMD52TEXTjuliana_borgeselessa_IOC-2015.pdf.txtjuliana_borgeselessa_IOC-2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
title Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
spellingShingle Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
Borges, Juliana Pereira
Myocardial Infarction
Exercise/physiology
Myocardial Reperfusion Injury/etiology
Myocardial Ischemia
Heat-Shock Proteins
Infarto do Miocárdio
Reperfusão Miocárdica
Traumatismo por Reperfusão Miocárdica
Isquemia Miocárdica
Proteínas de Choque Térmico
title_short Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
title_full Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
title_fullStr Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
title_full_unstemmed Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
title_sort Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review
author Borges, Juliana Pereira
author_facet Borges, Juliana Pereira
Lessa, Marcos Adriano
author_role author
author2 Lessa, Marcos Adriano
author2_role author
dc.contributor.author.fl_str_mv Borges, Juliana Pereira
Lessa, Marcos Adriano
dc.subject.en.pt_BR.fl_str_mv Myocardial Infarction
Exercise/physiology
Myocardial Reperfusion Injury/etiology
Myocardial Ischemia
Heat-Shock Proteins
topic Myocardial Infarction
Exercise/physiology
Myocardial Reperfusion Injury/etiology
Myocardial Ischemia
Heat-Shock Proteins
Infarto do Miocárdio
Reperfusão Miocárdica
Traumatismo por Reperfusão Miocárdica
Isquemia Miocárdica
Proteínas de Choque Térmico
dc.subject.decs.pt_BR.fl_str_mv Infarto do Miocárdio
Reperfusão Miocárdica
Traumatismo por Reperfusão Miocárdica
Isquemia Miocárdica
Proteínas de Choque Térmico
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-18T12:45:49Z
dc.date.available.fl_str_mv 2016-04-18T12:45:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BORGES, Juliana Pereira; LESSA, Marcos Adriano. Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review. Arq. Bras Cardiol., v.105, n.1, p.71-81, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13841
dc.identifier.issn.none.fl_str_mv 0066-782X
dc.identifier.doi.none.fl_str_mv 10.5935/abc.20150024
dc.identifier.eissn.none.fl_str_mv 1678-4170
identifier_str_mv BORGES, Juliana Pereira; LESSA, Marcos Adriano. Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review. Arq. Bras Cardiol., v.105, n.1, p.71-81, 2015.
0066-782X
10.5935/abc.20150024
1678-4170
url https://www.arca.fiocruz.br/handle/icict/13841
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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