Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48473 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil. |
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Morgado, Sergio MascarenhasVicente, Ana Carolina Paulo2021-08-02T14:46:46Z2021-08-02T14:46:46Z2021MORGADO, Sergio Mascarenhas; VICENTE, Ana Carolina Paulo. Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity.Microbial Genomics, v. 7, 000533, 17 p, Feb. 2021.2057-5888https://www.arca.fiocruz.br/handle/icict/4847310.1099/mgen.0.000533engMicrobiology SocietyMycolicibacterium mobilomeLevantamento in silicoDiversidade ainda pouco exploradaMycolicibacterium mobilomeSilico surveyRevealsYet underexplored diversityComprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.The mobilome plays a crucial role in bacterial adaptation and is therefore a starting point to understand and establish the gene flow occurring in the process of bacterial evolution. This is even more so if we consider that the mobilome of environmental bacteria can be the reservoir of genes that may later appear in the clinic. Recently, new genera have been proposed in the family Mycobacteriaceae, including the genus Mycolicibacterium, which encompasses dozens of species of agricultural, biotechnologi cal, clinical and ecological importance, being ubiquitous in several environments. The current scenario in the Mycobacteriaceae mobilome has some bias because most of the characterized mycobacteriophages were isolated using a single host strain, and the few plasmids reported mainly relate to the genus Mycobacterium. To fill in the gaps in these issues, we performed a systematic in silico study of these mobile elements based on 242 available genomes of the genus Mycolicibacterium. The analyses identified 156 putative plasmids (19 conjugative, 45 mobilizable and 92 non-mobilizable) and 566 prophages in 86 and 229 genomes, respectively. Moreover, a contig was characterized by resembling an actinomycete integrative and conjuga tive element (AICE). Within this diversity of mobile genetic elements, there is a pool of genes associated with several canonical functions, in addition to adaptive traits, such as virulence and resistance to antibiotics and metals (mercury and arsenic). The type-VII secretion system was a common feature in the predicted plasmids, being associated with genes encoding virulent pro teins (EsxA, EsxB, PE and PPE). In addition to the characterization of plasmids and prophages of the family Mycobacteriaceae, this study showed an abundance of these genetic elements in a dozen species of the genus Mycolicibacterium.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48473/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnaCarolinaVicente2_etal_IOC_2021.pdfAnaCarolinaVicente2_etal_IOC_2021.pdfapplication/pdf3757549https://www.arca.fiocruz.br/bitstream/icict/48473/2/AnaCarolinaVicente2_etal_IOC_2021.pdf424dc6a16a50e1ba8f63665e0418daa3MD52TEXTAnaCarolinaVicente2_etal_IOC_2021.pdf.txtAnaCarolinaVicente2_etal_IOC_2021.pdf.txtExtracted texttext/plain83660https://www.arca.fiocruz.br/bitstream/icict/48473/3/AnaCarolinaVicente2_etal_IOC_2021.pdf.txtcc2c8bd39ece95092100e767a9fee886MD53icict/484732021-08-03 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dc.title.pt_BR.fl_str_mv |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
title |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
spellingShingle |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity Morgado, Sergio Mascarenhas Mycolicibacterium mobilome Levantamento in silico Diversidade ainda pouco explorada Mycolicibacterium mobilome Silico survey Reveals Yet underexplored diversity |
title_short |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
title_full |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
title_fullStr |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
title_full_unstemmed |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
title_sort |
Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity |
author |
Morgado, Sergio Mascarenhas |
author_facet |
Morgado, Sergio Mascarenhas Vicente, Ana Carolina Paulo |
author_role |
author |
author2 |
Vicente, Ana Carolina Paulo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Morgado, Sergio Mascarenhas Vicente, Ana Carolina Paulo |
dc.subject.other.pt_BR.fl_str_mv |
Mycolicibacterium mobilome Levantamento in silico Diversidade ainda pouco explorada |
topic |
Mycolicibacterium mobilome Levantamento in silico Diversidade ainda pouco explorada Mycolicibacterium mobilome Silico survey Reveals Yet underexplored diversity |
dc.subject.en.pt_BR.fl_str_mv |
Mycolicibacterium mobilome Silico survey Reveals Yet underexplored diversity |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-08-02T14:46:46Z |
dc.date.available.fl_str_mv |
2021-08-02T14:46:46Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MORGADO, Sergio Mascarenhas; VICENTE, Ana Carolina Paulo. Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity.Microbial Genomics, v. 7, 000533, 17 p, Feb. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/48473 |
dc.identifier.issn.pt_BR.fl_str_mv |
2057-5888 |
dc.identifier.doi.none.fl_str_mv |
10.1099/mgen.0.000533 |
identifier_str_mv |
MORGADO, Sergio Mascarenhas; VICENTE, Ana Carolina Paulo. Comprehensive in silico survey of the Mycolicibacterium mobilome reveals an as yet underexplored diversity.Microbial Genomics, v. 7, 000533, 17 p, Feb. 2021. 2057-5888 10.1099/mgen.0.000533 |
url |
https://www.arca.fiocruz.br/handle/icict/48473 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Microbiology Society |
publisher.none.fl_str_mv |
Microbiology Society |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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