Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27204 |
Resumo: | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Oliveira, Ricardo RiccioFigueiredo, Joanemile Pacheco deCardoso, Luciana SantosJabar, Rafael LessaSouza, Robson PWells, Martin TCarvalho Filho, Edgar MarcelinoFitzgerald, Daniel WBarnes, Kathleen CAraújo, Maria Ilma Andrade SantosGlesby, Marshall J2018-06-29T17:23:51Z2018-06-29T17:23:51Z2012OLIVEIRA, R. R. et al. Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil. American Journal of Tropical Medicine and Hygiene, v. 86, n. 2, p. 296–305, 2012.0002-9637https://www.arca.fiocruz.br/handle/icict/2720410.4269/ajtmh.2012.11-0204Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian National Research Council (CNPq) Universal (482064/2010-2). Ricardo R. Oliveira and Marshall J. Glesby were supported in part by the Fogarty/Ellison International Clinical Research Scholars Program and National Institutes of Health/National Institutes of Allergy and Infectious Diseases grant K24Al078884.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilCornell University. Department of Biological Statistics and Computational Biology. Ithaca, NYUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana deMedicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacionalde Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilWeill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. Department of Medicine. New York, NYJohns Hopkins University. Department of Medicine. Division of Allergy and Clinical Immunology. Baltimore, MDUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilWeill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. Department of Medicine. New York, NYDetailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult worm antigen (SWAP) and against interleukin-4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.engAmerican Society of Tropical Medicine and HygieneSchistosoma mansoniInfecçãoEsquistosomoseHumanosFatores socioeconômicoSchistosoma mansoniInfectionSchistosomiasisHumansSocioeconomic factorsFactors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27204/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOliveira RR Factors associated with resistance....pdfOliveira RR Factors associated with 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| dc.title.pt_BR.fl_str_mv |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| title |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| spellingShingle |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil Oliveira, Ricardo Riccio Schistosoma mansoni Infecção Esquistosomose Humanos Fatores socioeconômico Schistosoma mansoni Infection Schistosomiasis Humans Socioeconomic factors |
| title_short |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| title_full |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| title_fullStr |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| title_full_unstemmed |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| title_sort |
Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil |
| author |
Oliveira, Ricardo Riccio |
| author_facet |
Oliveira, Ricardo Riccio Figueiredo, Joanemile Pacheco de Cardoso, Luciana Santos Jabar, Rafael Lessa Souza, Robson P Wells, Martin T Carvalho Filho, Edgar Marcelino Fitzgerald, Daniel W Barnes, Kathleen C Araújo, Maria Ilma Andrade Santos Glesby, Marshall J |
| author_role |
author |
| author2 |
Figueiredo, Joanemile Pacheco de Cardoso, Luciana Santos Jabar, Rafael Lessa Souza, Robson P Wells, Martin T Carvalho Filho, Edgar Marcelino Fitzgerald, Daniel W Barnes, Kathleen C Araújo, Maria Ilma Andrade Santos Glesby, Marshall J |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Ricardo Riccio Figueiredo, Joanemile Pacheco de Cardoso, Luciana Santos Jabar, Rafael Lessa Souza, Robson P Wells, Martin T Carvalho Filho, Edgar Marcelino Fitzgerald, Daniel W Barnes, Kathleen C Araújo, Maria Ilma Andrade Santos Glesby, Marshall J |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni Infecção Esquistosomose Humanos Fatores socioeconômico |
| topic |
Schistosoma mansoni Infecção Esquistosomose Humanos Fatores socioeconômico Schistosoma mansoni Infection Schistosomiasis Humans Socioeconomic factors |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Infection Schistosomiasis Humans Socioeconomic factors |
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Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino de. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2012 |
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2012 |
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2018-06-29T17:23:51Z |
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OLIVEIRA, R. R. et al. Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil. American Journal of Tropical Medicine and Hygiene, v. 86, n. 2, p. 296–305, 2012. |
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0002-9637 |
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10.4269/ajtmh.2012.11-0204 |
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OLIVEIRA, R. R. et al. Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil. American Journal of Tropical Medicine and Hygiene, v. 86, n. 2, p. 296–305, 2012. 0002-9637 10.4269/ajtmh.2012.11-0204 |
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