Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19

Detalhes bibliográficos
Autor(a) principal: Adesse, Daniel
Data de Publicação: 2022
Outros Autores: Gladulich, Luis, Alvarez‑Rosa, Liandra, Siqueira, Michele, Marcos, Anne Caroline, Heider, Marialice, Motta, Caroline Soares, Torices, Silvia, Toborek, Michal, Stipursky, Joice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55424
Resumo: Fundação Oswaldo Cruz (Edital INOVA COVID19—Geração de Conhecimento 2020, Grant number 48401984391807 for D.A.)
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spelling Adesse, DanielGladulich, LuisAlvarez‑Rosa, LiandraSiqueira, MicheleMarcos, Anne CarolineHeider, MarialiceMotta, Caroline SoaresTorices, SilviaToborek, MichalStipursky, Joice2022-11-01T11:25:11Z2022-11-01T11:25:11Z2022ADESSE, Daniel et al. Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19. Fluids and Barriers of the CNS, v. 19, n. 63, p. 1-19, 18 Aug. 2022.2045-8118https://www.arca.fiocruz.br/handle/icict/5542410.1186/s12987-022-00357-52045-8118Fundação Oswaldo Cruz (Edital INOVA COVID19—Geração de Conhecimento 2020, Grant number 48401984391807 for D.A.)Fundação Carlos Chagas Filho de Amparo à Pesquisa do Rio de Janeiro (FAPERJ, Grant numbers E-26/210.247/2020, E-26/211.118/2021 for D.A.)(Jovem Cientista do Nosso Estado, FAPERJ), Grant numbers E-26/201.336/2021 (D.A) and E-26/201.427/2021 (J.S.)Florida Department of Health Grant 8AZ24National Institutes of Health (NIH) Grants MH128022, MH122235, MH072567, HL126559, DA044579, DA039576, DA040537, DA050528, and DA047157NSC Grant 2019/35/B/NZ7/03155Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / University of Miami. Miller School of Medicine. Department of Biochemistry and Molecular Biology. Miami, FL, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Laboratório Compartilhado. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Laboratório Compartilhado. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil.University of Miami. Miller School of Medicine. Department of Biochemistry and Molecular Biology. Miami, FL, USA.University of Miami. Miller School of Medicine. Department of Biochemistry and Molecular Biology. Miami, FL, USA / The Jerzy Kukuczka Academy of Physical Education. Institute of Physiotherapy and Health Sciences. Katowice, Poland.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Laboratório Compartilhado. Rio de Janeiro, RJ, Brasil.COVID-19, which is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), has resulted in devastating morbidity and mortality worldwide due to lethal pneumonia and respiratory distress. In addition, the central nervous system (CNS) is well documented to be a target of SARS-CoV-2, and studies detected SARS-CoV-2 in the brain and the cerebrospinal fuid of COVID-19 patients. The blood–brain barrier (BBB) was suggested to be the major route of SARS-CoV-2 infection of the brain. Functionally, the BBB is created by an interactome between endothelial cells, pericytes, astrocytes, microglia, and neurons, which form the neurovascular units (NVU). However, at present, the interactions of SARS-CoV-2 with the NVU and the outcomes of this process are largely unknown. Moreover, age was described as one of the most prominent risk factors for hospitalization and deaths, along with other comorbidities such as diabetes and co-infections. This review will discuss the impact of SARS-CoV-2 on the NVU, the expression profle of SARS-CoV-2 receptors in the diferent cell types of the CNS and the possible role of aging in the neurological outcomes of COVID-19. A special emphasis will be placed on mitochondrial functions because dysfunctional mitochondria are also a strong inducer of infammatory reactions and the “cytokine storm” associated with SARS-CoV-2 infection. Finally, we will discuss possible drug therapies to treat neural endothelial function in aged patients, and, thus, alleviate the neurological symptoms associated with COVID-19.engBMCCOVID-19SARS-CoV-2Sintomas neurológicosPapel do envelhecimentoBarreira hematoencefálicaCOVID-19SARS‑CoV‑2Neurological symptomsRole of agingBlood–Brain Barrier dysfunctionRole of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
title Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
spellingShingle Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
Adesse, Daniel
COVID-19
SARS-CoV-2
Sintomas neurológicos
Papel do envelhecimento
Barreira hematoencefálica
COVID-19
SARS‑CoV‑2
Neurological symptoms
Role of aging
Blood–Brain Barrier dysfunction
title_short Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
title_full Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
title_fullStr Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
title_full_unstemmed Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
title_sort Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19
author Adesse, Daniel
author_facet Adesse, Daniel
Gladulich, Luis
Alvarez‑Rosa, Liandra
Siqueira, Michele
Marcos, Anne Caroline
Heider, Marialice
Motta, Caroline Soares
Torices, Silvia
Toborek, Michal
Stipursky, Joice
author_role author
author2 Gladulich, Luis
Alvarez‑Rosa, Liandra
Siqueira, Michele
Marcos, Anne Caroline
Heider, Marialice
Motta, Caroline Soares
Torices, Silvia
Toborek, Michal
Stipursky, Joice
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Adesse, Daniel
Gladulich, Luis
Alvarez‑Rosa, Liandra
Siqueira, Michele
Marcos, Anne Caroline
Heider, Marialice
Motta, Caroline Soares
Torices, Silvia
Toborek, Michal
Stipursky, Joice
dc.subject.other.en_US.fl_str_mv COVID-19
SARS-CoV-2
Sintomas neurológicos
Papel do envelhecimento
Barreira hematoencefálica
topic COVID-19
SARS-CoV-2
Sintomas neurológicos
Papel do envelhecimento
Barreira hematoencefálica
COVID-19
SARS‑CoV‑2
Neurological symptoms
Role of aging
Blood–Brain Barrier dysfunction
dc.subject.en.en_US.fl_str_mv COVID-19
SARS‑CoV‑2
Neurological symptoms
Role of aging
Blood–Brain Barrier dysfunction
description Fundação Oswaldo Cruz (Edital INOVA COVID19—Geração de Conhecimento 2020, Grant number 48401984391807 for D.A.)
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-11-01T11:25:11Z
dc.date.available.fl_str_mv 2022-11-01T11:25:11Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ADESSE, Daniel et al. Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19. Fluids and Barriers of the CNS, v. 19, n. 63, p. 1-19, 18 Aug. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55424
dc.identifier.issn.en_US.fl_str_mv 2045-8118
dc.identifier.doi.none.fl_str_mv 10.1186/s12987-022-00357-5
dc.identifier.eissn.none.fl_str_mv 2045-8118
identifier_str_mv ADESSE, Daniel et al. Role of aging in blood–brain barrier dysfunction and susceptibility to SARS-CoV-2 infection: impacts on neurological symptoms of COVID-19. Fluids and Barriers of the CNS, v. 19, n. 63, p. 1-19, 18 Aug. 2022.
2045-8118
10.1186/s12987-022-00357-5
url https://www.arca.fiocruz.br/handle/icict/55424
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55424/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55424/2/DanielAdesse_MicheleSiqueira_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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