High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45430 |
Resumo: | Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. |
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Castro, Viviane de Oliveira Landgraf deKamili, SaleemForbi, Joseph C.Stabile, Andréa CristinaSilva, Elizeu Ferreira daOliveira, Sandra Maria do Valle Leone deCarvalho, Paula Renata Tedesco dePuga, Marco Antonio MoreiraTanaka, Tayana Serpa OrtizLago, Barbara Vieira doIbanhes, Mary LuizaAraujo, AufraTejada-Strop, AlexandraLin, YulinXia, Guo-LiangSue, AmandaTeles, Sheila AraújoCastro, Ana Rita Coimbra Motta2020-12-26T18:00:41Z2020-12-26T18:00:41Z2020CASTRO, Viviane de Oliveira Landgrad de et al. High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil, Infection, Genetics and Evolution, v. 85, 104488, p. 1-9, July 2020.1567-1348https://www.arca.fiocruz.br/handle/icict/4543010.1016/j.meegid.2020.104488engScience DirectVírus da DengueEpidemiologia molecularBrasilCrackDrogasCampo GrandeMato Grosso do SulHepatitis C virusCrack cocaineMolecular epidemiologyBrazilState of Mato Grosso do SulHigh prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Saúde Pública de Mato Grosso do Sul. Campo Grande, MS, Brasil.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Centers for Disease Control and Prevention. Atlanta, Georgia, USA.Universidade Federal de Goiás. Goiânia, GO, Brasil.Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil.In this study, the prevalence rate, associated risk factors and genetic diversity of hepatitis C virus (HCV) infection were determined among people who use crack from an international drug trafficking route in Central-West, Brazil. Blood samples were collected from 700 users of crack from Campo Grande and two border cities of Mato Grosso do Sul State and tested for HCV infection using serological and molecular testing methodologies. Anti-HCV was detected in 31/700 (4.5%, 95% CI: 2.9–6.0%) and HCV RNA in 26/31 (83.9%) of anti-HCV positive samples. Phylogenetic analysis of three HCV sub-genomic regions (5’UTR, NS5B and HVR-1) revealed the circulation of 1a (73.9%), 1b (8.7%) and 3a (17.4%) genotypes. Next-generation sequencing and phylogenetic analysis of intra-host viral populations of HCV HVR-1 showed a significant variation in intra-host genetic diversity among infected individuals, with 58.8% composed of more than one sub-population. Bayesian analysis estimated that the most recent common HCV ancestor for strains identified here was introduced to this region after 1975 following expansion of intravenous drug use in Brazil. Multivariate analyses showed that only ‘ever having injected drugs' was independently associated with HCV infection. These results indicate an increasing spread of multiple HCV strains requiring public health intervention, such as harm reduction, testing services and treatment among crack users in this important border region of Central Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45430/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarbaraV_Lago_etal_IOC_2020.pdfBarbaraV_Lago_etal_IOC_2020.pdfapplication/pdf1261398https://www.arca.fiocruz.br/bitstream/icict/45430/2/BarbaraV_Lago_etal_IOC_2020.pdf65695a321d6a6db7a357f7a4f6a1b1f6MD52TEXTBarbaraV_Lago_etal_IOC_2020.pdf.txtBarbaraV_Lago_etal_IOC_2020.pdf.txtExtracted texttext/plain49432https://www.arca.fiocruz.br/bitstream/icict/45430/3/BarbaraV_Lago_etal_IOC_2020.pdf.txt546c4e4d91c9b1d7f1f3387f349f0435MD53icict/454302022-06-24 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| dc.title.pt_BR.fl_str_mv |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| title |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| spellingShingle |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil Castro, Viviane de Oliveira Landgraf de Vírus da Dengue Epidemiologia molecular Brasil Crack Drogas Campo Grande Mato Grosso do Sul Hepatitis C virus Crack cocaine Molecular epidemiology Brazil State of Mato Grosso do Sul |
| title_short |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| title_full |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| title_fullStr |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| title_full_unstemmed |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| title_sort |
High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil |
| author |
Castro, Viviane de Oliveira Landgraf de |
| author_facet |
Castro, Viviane de Oliveira Landgraf de Kamili, Saleem Forbi, Joseph C. Stabile, Andréa Cristina Silva, Elizeu Ferreira da Oliveira, Sandra Maria do Valle Leone de Carvalho, Paula Renata Tedesco de Puga, Marco Antonio Moreira Tanaka, Tayana Serpa Ortiz Lago, Barbara Vieira do Ibanhes, Mary Luiza Araujo, Aufra Tejada-Strop, Alexandra Lin, Yulin Xia, Guo-Liang Sue, Amanda Teles, Sheila Araújo Castro, Ana Rita Coimbra Motta |
| author_role |
author |
| author2 |
Kamili, Saleem Forbi, Joseph C. Stabile, Andréa Cristina Silva, Elizeu Ferreira da Oliveira, Sandra Maria do Valle Leone de Carvalho, Paula Renata Tedesco de Puga, Marco Antonio Moreira Tanaka, Tayana Serpa Ortiz Lago, Barbara Vieira do Ibanhes, Mary Luiza Araujo, Aufra Tejada-Strop, Alexandra Lin, Yulin Xia, Guo-Liang Sue, Amanda Teles, Sheila Araújo Castro, Ana Rita Coimbra Motta |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, Viviane de Oliveira Landgraf de Kamili, Saleem Forbi, Joseph C. Stabile, Andréa Cristina Silva, Elizeu Ferreira da Oliveira, Sandra Maria do Valle Leone de Carvalho, Paula Renata Tedesco de Puga, Marco Antonio Moreira Tanaka, Tayana Serpa Ortiz Lago, Barbara Vieira do Ibanhes, Mary Luiza Araujo, Aufra Tejada-Strop, Alexandra Lin, Yulin Xia, Guo-Liang Sue, Amanda Teles, Sheila Araújo Castro, Ana Rita Coimbra Motta |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Dengue Epidemiologia molecular Brasil Crack Drogas Campo Grande Mato Grosso do Sul |
| topic |
Vírus da Dengue Epidemiologia molecular Brasil Crack Drogas Campo Grande Mato Grosso do Sul Hepatitis C virus Crack cocaine Molecular epidemiology Brazil State of Mato Grosso do Sul |
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Hepatitis C virus Crack cocaine Molecular epidemiology Brazil State of Mato Grosso do Sul |
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Universidade Federal de Mato Grosso do Sul. Laboratório de Imunologia Clínica. Campo Grande, MS, Brasil. |
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2020 |
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2020-12-26T18:00:41Z |
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2020-12-26T18:00:41Z |
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2020 |
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info:eu-repo/semantics/article |
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CASTRO, Viviane de Oliveira Landgrad de et al. High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil, Infection, Genetics and Evolution, v. 85, 104488, p. 1-9, July 2020. |
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https://www.arca.fiocruz.br/handle/icict/45430 |
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1567-1348 |
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10.1016/j.meegid.2020.104488 |
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CASTRO, Viviane de Oliveira Landgrad de et al. High prevalence of Hepatitis C Virus infection among people who use crack cocaine in an important international drug trafficking route in Central-West Region Brazil, Infection, Genetics and Evolution, v. 85, 104488, p. 1-9, July 2020. 1567-1348 10.1016/j.meegid.2020.104488 |
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Science Direct |
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