Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Brasil, Patrícia
Data de Publicação: 2022
Outros Autores: Damasceno, Luana, Fuller, Trevon, Bastos, Leonardo S., Cruz, Oswaldo G., Medeiros, Fernando, Calvet, Guilherme Amaral, Resende, Paola, Whitworth, Jimmy, Smith, Chris, Siqueira, Marilda M., Carvalho, Marilia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59098
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Brasil, PatríciaDamasceno, LuanaFuller, TrevonBastos, Leonardo S.Cruz, Oswaldo G.Medeiros, FernandoCalvet, Guilherme AmaralResende, PaolaWhitworth, JimmySmith, ChrisSiqueira, Marilda M.Carvalho, Marilia2023-06-21T14:14:40Z2023-06-21T14:14:40Z2022BRASIL, Patrícia et al. Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil. BMJ Open, v. 12, p. 1-7, Nov. 2022.1756-1833https://www.arca.fiocruz.br/handle/icict/5909810.1136/ bmjopen-2022-067212engBMJSARS-CoV- 2Perfil de coorteTransmissão domésticaComunidade de Baixo recursoSARS-CoV- 2Cohort-profileHousehold transmissionBrazilCohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Institute of the Environment & Sustainability, University of California Los Angeles, Los Angeles, California, USA.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brasil.International Public Health. LSHTM, London, UK.Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK / School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Purpose To better understand the household transmission of SARS-COV- 2 in a low-resource community in Rio de Janeiro during the COVID-19 pandemic (2020–2022). Participants This is an open prospective cohort study of children ≤12 years old and their household contacts. During home visits over 24 months, we collected data on sociodemographic characteristics, behavioural data, clinical manifestations of SARS-CoV- 2, vaccination status, SARS-CoV- 2 (reverse transcription-polymerase chain reaction) RT-PCR and anti-S antibody tests. Among adults, the majority of participants were women (62%). Findings to date We enrolled 845 families from May 2020 to May 2022. The median number of residents per household was four. The median household density, defined as the number of persons per room, was 0.95. The risk of SARS-CoV- 2 occurrence was higher in households with a high number of persons per room. Children were not the principal source of SARS-CoV- 2 infections in their households during the first wave of the pandemic. Future plans Future studies will investigate cellular and humoral immune responses to locally circulating SARS-CoV- 2 variants, which is relevant for the design of vaccines, antivirals and monoclonal antibodies. We will also engage in outreach to encourage vaccination as a means of limiting the transmission of novel SARS-CoV- 2 variants and other emerging pathogens.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59098/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaBrasil_PaolaRezende_etal_IOC_2023.pdfPatriciaBrasil_PaolaRezende_etal_IOC_2023.pdfapplication/pdf526240https://www.arca.fiocruz.br/bitstream/icict/59098/2/PatriciaBrasil_PaolaRezende_etal_IOC_2023.pdf88c4f44d7c8867a4ab53ac7feb9fcd12MD52icict/590982023-09-14 16:02:14.856oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T19:02:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
title Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
spellingShingle Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
Brasil, Patrícia
SARS-CoV- 2
Perfil de coorte
Transmissão doméstica
Comunidade de Baixo recurso
SARS-CoV- 2
Cohort-profile
Household transmission
Brazil
title_short Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
title_full Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
title_fullStr Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
title_full_unstemmed Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
title_sort Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil
author Brasil, Patrícia
author_facet Brasil, Patrícia
Damasceno, Luana
Fuller, Trevon
Bastos, Leonardo S.
Cruz, Oswaldo G.
Medeiros, Fernando
Calvet, Guilherme Amaral
Resende, Paola
Whitworth, Jimmy
Smith, Chris
Siqueira, Marilda M.
Carvalho, Marilia
author_role author
author2 Damasceno, Luana
Fuller, Trevon
Bastos, Leonardo S.
Cruz, Oswaldo G.
Medeiros, Fernando
Calvet, Guilherme Amaral
Resende, Paola
Whitworth, Jimmy
Smith, Chris
Siqueira, Marilda M.
Carvalho, Marilia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brasil, Patrícia
Damasceno, Luana
Fuller, Trevon
Bastos, Leonardo S.
Cruz, Oswaldo G.
Medeiros, Fernando
Calvet, Guilherme Amaral
Resende, Paola
Whitworth, Jimmy
Smith, Chris
Siqueira, Marilda M.
Carvalho, Marilia
dc.subject.other.en_US.fl_str_mv SARS-CoV- 2
Perfil de coorte
Transmissão doméstica
Comunidade de Baixo recurso
topic SARS-CoV- 2
Perfil de coorte
Transmissão doméstica
Comunidade de Baixo recurso
SARS-CoV- 2
Cohort-profile
Household transmission
Brazil
dc.subject.en.en_US.fl_str_mv SARS-CoV- 2
Cohort-profile
Household transmission
Brazil
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-06-21T14:14:40Z
dc.date.available.fl_str_mv 2023-06-21T14:14:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRASIL, Patrícia et al. Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil. BMJ Open, v. 12, p. 1-7, Nov. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59098
dc.identifier.issn.en_US.fl_str_mv 1756-1833
dc.identifier.doi.none.fl_str_mv 10.1136/ bmjopen-2022-067212
identifier_str_mv BRASIL, Patrícia et al. Cohort-profile: Household transmission of SARS-CoV- 2 in a low-resource community in Rio de Janeiro, Brazil. BMJ Open, v. 12, p. 1-7, Nov. 2022.
1756-1833
10.1136/ bmjopen-2022-067212
url https://www.arca.fiocruz.br/handle/icict/59098
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ
publisher.none.fl_str_mv BMJ
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59098/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59098/2/PatriciaBrasil_PaolaRezende_etal_IOC_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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