Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46317 |
Resumo: | Federal University of Rio de Janeiro. Faculty of Medicine, Postgraduate in Infectious and Parasitic Diseases. Rio de Janeiro, RJ, Brazil / Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil. |
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Kalil, Rosangela SouzaVasconcellos, IsabelleRosadas, CarolinaCony, AndreaLima, Dulcino P.Gonçalves, Cassia C. AlvesBatista, EvertonGrassi, Maria Fernanda RiosCastro Filho, Bernardo GalvãoTaylor, Graham P.Sohler, Marzia Puccioni2021-03-10T11:47:46Z2021-03-10T11:47:46Z2021KALIL, Rosangela Souza et al. Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals. Journal of NeuroVirology, 2021.1538-2443https://www.arca.fiocruz.br/handle/icict/4631710.1007/s13365-021-00944-6engSpringerHTLV-1 ·MielopatiaParaparesia Espástica Tropical ·Disfunção cognitivo ·Imagem por Ressonância MagnéticaVírus Linfotrópico T Tipo 1 HumanoHTLV-1 ·HTLV-1-associated myelopathy ·Tropical spastic paraparesis ·Cognitive impairment ·Magnetic resonance imagingAssociation between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Rio de Janeiro. Faculty of Medicine, Postgraduate in Infectious and Parasitic Diseases. Rio de Janeiro, RJ, Brazil / Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil.Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil.Imperial College London. Department of Infectious Disease. London, UK.Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil.Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Postgraduate Biological Institute. Rio de Janeiro, RJ, Brazil.Bahiana School of Medicine. HTLV Integrative and Multidisciplinary Center. Salvador, BA, Brazil.Bahiana School of Medicine. HTLV Integrative and Multidisciplinary Center. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Bahia, Brasil.Imperial College London. Department of Infectious Disease. London, UK.Federal University of Rio de Janeiro. Faculty of Medicine, Postgraduate in Infectious and Parasitic Diseases. Rio de Janeiro, RJ, Brazil / Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil. / Federal University of the State of Rio de Janeiro. School of Medicine and Surgery, Department of General Medicine. Rio de Janeiro,RJ, Brazil.The association between high proviral load (PVL) in peripheral blood mononuclear cells (PBMC), cognitive disturbance and white matter brain lesions in HTLV-1-infected individuals is still undefined. A cross-sectional study included 62 participants: 22 asymptomatic carriers (mean age 43.4 ± 13.1 years old), 22 patients with HTLV-1-associated myelopathy (HAM/TSP) (mean age 51.5 ± 8.7 years old), and 18 uninfected controls (mean age 52.3 ± 11.1 years old). All individuals fulfilled the following criteria: between 18 and 65 years of age, more than 4 years of formal education, and completed neuropsychological evaluation and HTLV-1 serology. Infected individuals underwent brain conventional magnetic resonance imaging and PVL quantitative PCR (qPCR). Statistical analysis was adjusted in the models by age and education. Cognitive deficit was observed in all groups. Patients with HAM/TSP showed higher neurocognitive deviation in attention and motor skills, higher frequency (84%) of brain white matter lesions, and higher PVL median (range) 8.45 (0.5–71.4) copies/100 PBMC. Brain white matter lesion was associated with verbal memory deficit in HTLV-1-infected individuals (HAM/TSP and asymptomatic carriers) (p = 0.026). In addition, there was a correlation between higher PVL and neurocognitive dysfunction score (processing speed of visuomotor information and visuoconstructive praxis) in HTLV-1-infected patients. The study demonstrates an association between HTLV-1 infection, neurocognitive disorder, and white matter brain lesions on MRI as well as a correlation with higher HTLV-1 PVL, suggesting that the central nervous system involvement by HTLV-1 is not restricted to the spinal cord but involves the whole neuro-axis. HTLV-1-infected individuals should be tested for cognitive impairment.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46317/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALKalil, Souza Rosangela.Association....pdfKalil, Souza Rosangela.Association....pdfapplication/pdf635937https://www.arca.fiocruz.br/bitstream/icict/46317/2/Kalil%2c%20Souza%20Rosangela.Association....pdf34c6079abb0daf05727c463da31c7702MD52TEXTKalil, Souza Rosangela.Association....pdf.txtKalil, Souza Rosangela.Association....pdf.txtExtracted texttext/plain40935https://www.arca.fiocruz.br/bitstream/icict/46317/3/Kalil%2c%20Souza%20Rosangela.Association....pdf.txte8824d265b142fa5f7decf70e31ebab3MD53icict/463172023-03-15 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| dc.title.pt_BR.fl_str_mv |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| title |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| spellingShingle |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals Kalil, Rosangela Souza HTLV-1 · Mielopatia Paraparesia Espástica Tropical · Disfunção cognitivo · Imagem por Ressonância Magnética Vírus Linfotrópico T Tipo 1 Humano HTLV-1 · HTLV-1-associated myelopathy · Tropical spastic paraparesis · Cognitive impairment · Magnetic resonance imaging |
| title_short |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| title_full |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| title_fullStr |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| title_full_unstemmed |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| title_sort |
Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals |
| author |
Kalil, Rosangela Souza |
| author_facet |
Kalil, Rosangela Souza Vasconcellos, Isabelle Rosadas, Carolina Cony, Andrea Lima, Dulcino P. Gonçalves, Cassia C. Alves Batista, Everton Grassi, Maria Fernanda Rios Castro Filho, Bernardo Galvão Taylor, Graham P. Sohler, Marzia Puccioni |
| author_role |
author |
| author2 |
Vasconcellos, Isabelle Rosadas, Carolina Cony, Andrea Lima, Dulcino P. Gonçalves, Cassia C. Alves Batista, Everton Grassi, Maria Fernanda Rios Castro Filho, Bernardo Galvão Taylor, Graham P. Sohler, Marzia Puccioni |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Kalil, Rosangela Souza Vasconcellos, Isabelle Rosadas, Carolina Cony, Andrea Lima, Dulcino P. Gonçalves, Cassia C. Alves Batista, Everton Grassi, Maria Fernanda Rios Castro Filho, Bernardo Galvão Taylor, Graham P. Sohler, Marzia Puccioni |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-1 · Mielopatia Paraparesia Espástica Tropical · Disfunção cognitivo · Imagem por Ressonância Magnética Vírus Linfotrópico T Tipo 1 Humano |
| topic |
HTLV-1 · Mielopatia Paraparesia Espástica Tropical · Disfunção cognitivo · Imagem por Ressonância Magnética Vírus Linfotrópico T Tipo 1 Humano HTLV-1 · HTLV-1-associated myelopathy · Tropical spastic paraparesis · Cognitive impairment · Magnetic resonance imaging |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 · HTLV-1-associated myelopathy · Tropical spastic paraparesis · Cognitive impairment · Magnetic resonance imaging |
| description |
Federal University of Rio de Janeiro. Faculty of Medicine, Postgraduate in Infectious and Parasitic Diseases. Rio de Janeiro, RJ, Brazil / Federal University of the State of Rio de Janeiro. Gaffree and Guinle University Hospital. Neuroinfection Unit Immunology Service. Rio de Janeiro, RJ, Brazil. |
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2021 |
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2021-03-10T11:47:46Z |
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2021-03-10T11:47:46Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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KALIL, Rosangela Souza et al. Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals. Journal of NeuroVirology, 2021. |
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https://www.arca.fiocruz.br/handle/icict/46317 |
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1538-2443 |
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10.1007/s13365-021-00944-6 |
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KALIL, Rosangela Souza et al. Association between high proviral load, cognitive impairment, and white matter brain lesions in HTLV‑1‑infected individuals. Journal of NeuroVirology, 2021. 1538-2443 10.1007/s13365-021-00944-6 |
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